Arsenic Toxicity on Metabolism and Autophagy in Adipose and Muscle Tissues
Arsenic, a naturally occurring metalloid derived from the environment, has been studied worldwide for its causative effects in various cancers. However, the effects of arsenic toxicity on the development and progression of metabolic syndrome, including obesity and diabetes, has received less attenti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/4/689 |
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| author | Seung-Hyun Ro Jiyoung Bae Yura Jang Jacob F. Myers Soonkyu Chung Jiujiu Yu Sathish Kumar Natarajan Rodrigo Franco Hyun-Seob Song |
| author_facet | Seung-Hyun Ro Jiyoung Bae Yura Jang Jacob F. Myers Soonkyu Chung Jiujiu Yu Sathish Kumar Natarajan Rodrigo Franco Hyun-Seob Song |
| author_sort | Seung-Hyun Ro |
| collection | DOAJ |
| description | Arsenic, a naturally occurring metalloid derived from the environment, has been studied worldwide for its causative effects in various cancers. However, the effects of arsenic toxicity on the development and progression of metabolic syndrome, including obesity and diabetes, has received less attention. Many studies suggest that metabolic dysfunction and autophagy dysregulation of adipose and muscle tissues are closely related to the development of metabolic disease. In the USA, arsenic contamination has been reported in some ground water, soil and grain samples in major agricultural regions, but the effects on adipose and muscle tissue metabolism and autophagy have not been investigated much. Here, we highlight arsenic toxicity according to the species, dose and exposure time and the effects on adipose and muscle tissue metabolism and autophagy. Historically, arsenic was used as both a poison and medicine, depending on the dose and treatment time. In the modern era, arsenic intoxication has significantly increased due to exposure from water, soil and food, which could be a contributing factor in the development and progression of metabolic disease. From this review, a better understanding of the pathogenic mechanisms by which arsenic alters metabolism and autophagy regulation could become a cornerstone leading to the development of therapeutic strategies against arsenic-induced toxicity and metabolic disease. |
| first_indexed | 2024-03-09T11:14:11Z |
| format | Article |
| id | doaj.art-9e4def654b9f4923bbf5848757cba42d |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T11:14:11Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-9e4def654b9f4923bbf5848757cba42d2023-12-01T00:35:07ZengMDPI AGAntioxidants2076-39212022-03-0111468910.3390/antiox11040689Arsenic Toxicity on Metabolism and Autophagy in Adipose and Muscle TissuesSeung-Hyun Ro0Jiyoung Bae1Yura Jang2Jacob F. Myers3Soonkyu Chung4Jiujiu Yu5Sathish Kumar Natarajan6Rodrigo Franco7Hyun-Seob Song8Department of Biochemistry and the Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USADepartment of Biochemistry and the Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USADepartment of Biochemistry and the Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USADepartment of Biochemistry and the Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USADepartment of Nutrition, University of Massachusetts, Amherst, MA 01003, USADepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USADepartment of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USASchool of Veterinary Medicine and Biomedical Sciences and the Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68583, USADepartment of Biological Systems Engineering, University of Nebraska-Lincoln, Lincoln, NE 68583, USAArsenic, a naturally occurring metalloid derived from the environment, has been studied worldwide for its causative effects in various cancers. However, the effects of arsenic toxicity on the development and progression of metabolic syndrome, including obesity and diabetes, has received less attention. Many studies suggest that metabolic dysfunction and autophagy dysregulation of adipose and muscle tissues are closely related to the development of metabolic disease. In the USA, arsenic contamination has been reported in some ground water, soil and grain samples in major agricultural regions, but the effects on adipose and muscle tissue metabolism and autophagy have not been investigated much. Here, we highlight arsenic toxicity according to the species, dose and exposure time and the effects on adipose and muscle tissue metabolism and autophagy. Historically, arsenic was used as both a poison and medicine, depending on the dose and treatment time. In the modern era, arsenic intoxication has significantly increased due to exposure from water, soil and food, which could be a contributing factor in the development and progression of metabolic disease. From this review, a better understanding of the pathogenic mechanisms by which arsenic alters metabolism and autophagy regulation could become a cornerstone leading to the development of therapeutic strategies against arsenic-induced toxicity and metabolic disease.https://www.mdpi.com/2076-3921/11/4/689arsenicadiposemuscleautophagyoxidative stressmitochondrial dysfunction |
| spellingShingle | Seung-Hyun Ro Jiyoung Bae Yura Jang Jacob F. Myers Soonkyu Chung Jiujiu Yu Sathish Kumar Natarajan Rodrigo Franco Hyun-Seob Song Arsenic Toxicity on Metabolism and Autophagy in Adipose and Muscle Tissues Antioxidants arsenic adipose muscle autophagy oxidative stress mitochondrial dysfunction |
| title | Arsenic Toxicity on Metabolism and Autophagy in Adipose and Muscle Tissues |
| title_full | Arsenic Toxicity on Metabolism and Autophagy in Adipose and Muscle Tissues |
| title_fullStr | Arsenic Toxicity on Metabolism and Autophagy in Adipose and Muscle Tissues |
| title_full_unstemmed | Arsenic Toxicity on Metabolism and Autophagy in Adipose and Muscle Tissues |
| title_short | Arsenic Toxicity on Metabolism and Autophagy in Adipose and Muscle Tissues |
| title_sort | arsenic toxicity on metabolism and autophagy in adipose and muscle tissues |
| topic | arsenic adipose muscle autophagy oxidative stress mitochondrial dysfunction |
| url | https://www.mdpi.com/2076-3921/11/4/689 |
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