Toxicity Evaluation of Essential oil of Trachyspermum ammi in Acute and Sub-chronic Toxicity Experiments
Background: Trachyspermum ammi is one of the prominent plant in traditional medicine of the east with several medicinal effects such as improvement of stomach disease, digestive disorder, diarrhea, hemorrhoid, bladder stones, respiratory disease and etc. Medicinal plants is one of the important reas...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2019-03-01
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| Series: | Journal of Medicinal Plants |
| Subjects: | |
| Online Access: | http://jmp.ir/article-1-1846-en.html |
| _version_ | 1819107389949870080 |
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| author | M Vazirian D Hekmati SN Ostad A Manayi |
| author_facet | M Vazirian D Hekmati SN Ostad A Manayi |
| author_sort | M Vazirian |
| collection | DOAJ |
| description | Background: Trachyspermum ammi is one of the prominent plant in traditional medicine of the east with several medicinal effects such as improvement of stomach disease, digestive disorder, diarrhea, hemorrhoid, bladder stones, respiratory disease and etc. Medicinal plants is one of the important reason of toxicity particularly in children and the elderly therefore, evaluation of the toxic effects of a plant is important.
Objective: The aim of present study was evaluation of toxicity of ajowan oil in experimental animals.
Methods: Initially, essential oil of the plant fruit was extracted to study the acute toxicity to rats by gavage. The animals were treated with 1000 mg/kg of the essential oil for 23 and 45 days to determine chronic. Hematological and biochemical parameters of rats’ blood samples were collected and spleen, kidney, liver and lung of rats were isolated for histopathologic examination.
Results: According to acute studies result lethal dose, 50% (LD50) of ajowan essential oil was about 2294 mg/kg. Chronic evaluation showed that there is no statistical difference between weight, food and water consumption of test and control groups. Further, tissue analysis showed no serious change in examined tissues in the treated rats.
Conclusion: Finally according to results, no chemical parameters of blood and histological pattern of tissue were affected by T. ammi oil; however the oil could be classified as moderately toxic due to its LD50 value. |
| first_indexed | 2024-12-22T02:53:16Z |
| format | Article |
| id | doaj.art-9e4f6bad1d714067997ab60837f92d26 |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-22T02:53:16Z |
| publishDate | 2019-03-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-9e4f6bad1d714067997ab60837f92d262022-12-21T18:41:20ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582019-03-0118697077Toxicity Evaluation of Essential oil of Trachyspermum ammi in Acute and Sub-chronic Toxicity ExperimentsM Vazirian0D Hekmati1SN Ostad2A Manayi3 Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Faculty of Pharmacy, International Campus, Tehran University of Medical Sciences, Tehran, Iran Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Medicinal Plants Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Background: Trachyspermum ammi is one of the prominent plant in traditional medicine of the east with several medicinal effects such as improvement of stomach disease, digestive disorder, diarrhea, hemorrhoid, bladder stones, respiratory disease and etc. Medicinal plants is one of the important reason of toxicity particularly in children and the elderly therefore, evaluation of the toxic effects of a plant is important. Objective: The aim of present study was evaluation of toxicity of ajowan oil in experimental animals. Methods: Initially, essential oil of the plant fruit was extracted to study the acute toxicity to rats by gavage. The animals were treated with 1000 mg/kg of the essential oil for 23 and 45 days to determine chronic. Hematological and biochemical parameters of rats’ blood samples were collected and spleen, kidney, liver and lung of rats were isolated for histopathologic examination. Results: According to acute studies result lethal dose, 50% (LD50) of ajowan essential oil was about 2294 mg/kg. Chronic evaluation showed that there is no statistical difference between weight, food and water consumption of test and control groups. Further, tissue analysis showed no serious change in examined tissues in the treated rats. Conclusion: Finally according to results, no chemical parameters of blood and histological pattern of tissue were affected by T. ammi oil; however the oil could be classified as moderately toxic due to its LD50 value.http://jmp.ir/article-1-1846-en.html<i>trachyspermum ammi</i>acute toxicityajowanessential oil |
| spellingShingle | M Vazirian D Hekmati SN Ostad A Manayi Toxicity Evaluation of Essential oil of Trachyspermum ammi in Acute and Sub-chronic Toxicity Experiments Journal of Medicinal Plants <i>trachyspermum ammi</i> acute toxicity ajowan essential oil |
| title | Toxicity Evaluation of Essential oil of Trachyspermum ammi in Acute and Sub-chronic Toxicity Experiments |
| title_full | Toxicity Evaluation of Essential oil of Trachyspermum ammi in Acute and Sub-chronic Toxicity Experiments |
| title_fullStr | Toxicity Evaluation of Essential oil of Trachyspermum ammi in Acute and Sub-chronic Toxicity Experiments |
| title_full_unstemmed | Toxicity Evaluation of Essential oil of Trachyspermum ammi in Acute and Sub-chronic Toxicity Experiments |
| title_short | Toxicity Evaluation of Essential oil of Trachyspermum ammi in Acute and Sub-chronic Toxicity Experiments |
| title_sort | toxicity evaluation of essential oil of trachyspermum ammi in acute and sub chronic toxicity experiments |
| topic | <i>trachyspermum ammi</i> acute toxicity ajowan essential oil |
| url | http://jmp.ir/article-1-1846-en.html |
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