Homologous cardiac calcium pump regulators phospholamban and sarcolipin adopt distinct oligomeric states in the membrane

Homologous cardiac calcium pump regulators phospholamban and sarcolipin adopt distinct oligomeric states in the membrane

Phospholamban (PLN) and Sarcolipin (SLN) are homologous membrane proteins that belong to the family of proteins that regulate the activity of the cardiac calcium pump (sarcoplasmic reticulum Ca2+-ATPase, SERCA). PLN and SLN share highly conserved leucine zipper motifs that control self-association; ...

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Bibliographic Details
Main Authors: Andy Y. Liu, Rodrigo Aguayo-Ortiz, Guadalupe Guerrero-Serna, Nulang Wang, Muriel G. Blin, Daniel R. Goldstein, L. Michel Espinoza-Fonseca
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Calcium pump
Phospholamban
Sarcolipin
Oligomerization
Cardiac calcium regulation
Membrane proteins
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037021005407

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