Linear growth of corpus callosum and cerebellar vermis in very-low-birth-weight preterm infants
Background/Purpose: Impaired growth of the corpus callosum (CC) and cerebellar vermis (CV) is associated with poorer neurodevelopmental outcomes in preterm infants. However, references on the postnatal growth rate of the CC and CV by sonography are limited. The aim of this study is to assess the nor...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-08-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664620301212 |
| _version_ | 1818175220571176960 |
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| author | Hsin-Chung Huang Hung-Chieh Chou Po-Nien Tsao Chien-Yi Chen |
| author_facet | Hsin-Chung Huang Hung-Chieh Chou Po-Nien Tsao Chien-Yi Chen |
| author_sort | Hsin-Chung Huang |
| collection | DOAJ |
| description | Background/Purpose: Impaired growth of the corpus callosum (CC) and cerebellar vermis (CV) is associated with poorer neurodevelopmental outcomes in preterm infants. However, references on the postnatal growth rate of the CC and CV by sonography are limited. The aim of this study is to assess the normal linear growth of CC and CV using a serial cranial ultrasound. Methods: We prospectively enrolled preterm infants with very low birth weight from September 2008 to December 2009 after excluding those with congenital anomalies or diseases affecting the brain parenchyma. Serial sonographic measurements of the CC and CV were performed according to the standard protocol. Scheduled comprehensive neurodevelopmental evaluations were performed till the corrected age of 2 years. We excluded those with significant brain damages or poor neurodevelopmental outcomes in the final analysis. The growth rate was estimated using the loess smoothing curve and linear regression analysis. Results: Among the 86 enrolled neonates, 14 with significant brain damage and 8 with poor neurodevelopmental outcomes were excluded from the final analysis. The growth rate of the CC length was 1.72 (95% confidence interval [CI]: 1.24–2.20) and 0.57 (95% CI: 0.33–0.80) mm per week before and after the postmenstrual age of 30.5 weeks, respectively. The growth rate of the CV length was 0.78 (95% CI: 0.68–0.89) mm per week. Conclusion: We proposed reference values of the normal linear growth rate of the CC and CV lengths in very-low-birth-weight preterm infants using the serial cranial ultrasound. |
| first_indexed | 2024-12-11T19:56:50Z |
| format | Article |
| id | doaj.art-9e55ea123a2947568926002a8ba85ce8 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-11T19:56:50Z |
| publishDate | 2020-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-9e55ea123a2947568926002a8ba85ce82022-12-22T00:52:36ZengElsevierJournal of the Formosan Medical Association0929-66462020-08-01119812921298Linear growth of corpus callosum and cerebellar vermis in very-low-birth-weight preterm infantsHsin-Chung Huang0Hung-Chieh Chou1Po-Nien Tsao2Chien-Yi Chen3Department of Pediatrics, Taipei City Hospital, Heping FuYou Branch, Taipei, Taiwan; Department of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Research Center for Developmental Biology and Regenerative Medicine, National Taiwan University, Taipei, TaiwanDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Corresponding author. Department of Pediatrics, National Taiwan University Hospital, No. 7, Chung-Shan South Road, Taipei, 100, Taiwan. Fax: +886 2 23147450.Background/Purpose: Impaired growth of the corpus callosum (CC) and cerebellar vermis (CV) is associated with poorer neurodevelopmental outcomes in preterm infants. However, references on the postnatal growth rate of the CC and CV by sonography are limited. The aim of this study is to assess the normal linear growth of CC and CV using a serial cranial ultrasound. Methods: We prospectively enrolled preterm infants with very low birth weight from September 2008 to December 2009 after excluding those with congenital anomalies or diseases affecting the brain parenchyma. Serial sonographic measurements of the CC and CV were performed according to the standard protocol. Scheduled comprehensive neurodevelopmental evaluations were performed till the corrected age of 2 years. We excluded those with significant brain damages or poor neurodevelopmental outcomes in the final analysis. The growth rate was estimated using the loess smoothing curve and linear regression analysis. Results: Among the 86 enrolled neonates, 14 with significant brain damage and 8 with poor neurodevelopmental outcomes were excluded from the final analysis. The growth rate of the CC length was 1.72 (95% confidence interval [CI]: 1.24–2.20) and 0.57 (95% CI: 0.33–0.80) mm per week before and after the postmenstrual age of 30.5 weeks, respectively. The growth rate of the CV length was 0.78 (95% CI: 0.68–0.89) mm per week. Conclusion: We proposed reference values of the normal linear growth rate of the CC and CV lengths in very-low-birth-weight preterm infants using the serial cranial ultrasound.http://www.sciencedirect.com/science/article/pii/S0929664620301212Corpus callosumCerebellar vermisUltrasonographyGrowth |
| spellingShingle | Hsin-Chung Huang Hung-Chieh Chou Po-Nien Tsao Chien-Yi Chen Linear growth of corpus callosum and cerebellar vermis in very-low-birth-weight preterm infants Journal of the Formosan Medical Association Corpus callosum Cerebellar vermis Ultrasonography Growth |
| title | Linear growth of corpus callosum and cerebellar vermis in very-low-birth-weight preterm infants |
| title_full | Linear growth of corpus callosum and cerebellar vermis in very-low-birth-weight preterm infants |
| title_fullStr | Linear growth of corpus callosum and cerebellar vermis in very-low-birth-weight preterm infants |
| title_full_unstemmed | Linear growth of corpus callosum and cerebellar vermis in very-low-birth-weight preterm infants |
| title_short | Linear growth of corpus callosum and cerebellar vermis in very-low-birth-weight preterm infants |
| title_sort | linear growth of corpus callosum and cerebellar vermis in very low birth weight preterm infants |
| topic | Corpus callosum Cerebellar vermis Ultrasonography Growth |
| url | http://www.sciencedirect.com/science/article/pii/S0929664620301212 |
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