Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets
Prostate cancer (PCa) represents a major cause of cancer mortality among men in developed countries. Patients with recurrent disease initially respond to androgen-deprivation therapy, but the tumor eventually progresses into castration-resistant PCa; in this condition, tumor cells acquire the abilit...
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| Format: | Article |
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MDPI AG
2020-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/2/460 |
| _version_ | 1797716136316370944 |
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| author | Fabrizio Fontana Michela Raimondi Monica Marzagalli Alessandro Di Domizio Patrizia Limonta |
| author_facet | Fabrizio Fontana Michela Raimondi Monica Marzagalli Alessandro Di Domizio Patrizia Limonta |
| author_sort | Fabrizio Fontana |
| collection | DOAJ |
| description | Prostate cancer (PCa) represents a major cause of cancer mortality among men in developed countries. Patients with recurrent disease initially respond to androgen-deprivation therapy, but the tumor eventually progresses into castration-resistant PCa; in this condition, tumor cells acquire the ability to escape cell death and develop resistance to current therapies. Thus, new therapeutic approaches for PCa management are urgently needed. In this setting, natural products have been extensively studied for their anti-PCa activities, such as tumor growth suppression, cell death induction, and inhibition of metastasis and angiogenesis. Additionally, numerous studies have shown that phytochemicals can specifically target the androgen receptor (AR) signaling, as well as the PCa stem cells (PCSCs). Interestingly, many clinical trials have been conducted to test the efficacy of nutraceuticals in human subjects, and they have partially confirmed the promising results obtained in vitro and in preclinical models. This article summarizes the anti-cancer mechanisms and therapeutic potentials of different natural compounds in the context of PCa prevention and treatment. |
| first_indexed | 2024-03-12T08:17:05Z |
| format | Article |
| id | doaj.art-9e58f8672d28411dbd64a7db7e427ce2 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T08:17:05Z |
| publishDate | 2020-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-9e58f8672d28411dbd64a7db7e427ce22023-09-02T18:46:04ZengMDPI AGCells2073-44092020-02-019246010.3390/cells9020460cells9020460Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular TargetsFabrizio Fontana0Michela Raimondi1Monica Marzagalli2Alessandro Di Domizio3Patrizia Limonta4Department of Pharmacological and Biomolecular Sciences, University of Milano, 20133 Milano, ItalyDepartment of Pharmacological and Biomolecular Sciences, University of Milano, 20133 Milano, ItalyDepartment of Pharmacological and Biomolecular Sciences, University of Milano, 20133 Milano, ItalyDepartment of Pharmacological and Biomolecular Sciences, University of Milano, 20133 Milano, ItalyDepartment of Pharmacological and Biomolecular Sciences, University of Milano, 20133 Milano, ItalyProstate cancer (PCa) represents a major cause of cancer mortality among men in developed countries. Patients with recurrent disease initially respond to androgen-deprivation therapy, but the tumor eventually progresses into castration-resistant PCa; in this condition, tumor cells acquire the ability to escape cell death and develop resistance to current therapies. Thus, new therapeutic approaches for PCa management are urgently needed. In this setting, natural products have been extensively studied for their anti-PCa activities, such as tumor growth suppression, cell death induction, and inhibition of metastasis and angiogenesis. Additionally, numerous studies have shown that phytochemicals can specifically target the androgen receptor (AR) signaling, as well as the PCa stem cells (PCSCs). Interestingly, many clinical trials have been conducted to test the efficacy of nutraceuticals in human subjects, and they have partially confirmed the promising results obtained in vitro and in preclinical models. This article summarizes the anti-cancer mechanisms and therapeutic potentials of different natural compounds in the context of PCa prevention and treatment.https://www.mdpi.com/2073-4409/9/2/460prostate cancernatural compoundsphytochemicalschemopreventionnovel therapeutic strategies |
| spellingShingle | Fabrizio Fontana Michela Raimondi Monica Marzagalli Alessandro Di Domizio Patrizia Limonta Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets Cells prostate cancer natural compounds phytochemicals chemoprevention novel therapeutic strategies |
| title | Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets |
| title_full | Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets |
| title_fullStr | Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets |
| title_full_unstemmed | Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets |
| title_short | Natural Compounds in Prostate Cancer Prevention and Treatment: Mechanisms of Action and Molecular Targets |
| title_sort | natural compounds in prostate cancer prevention and treatment mechanisms of action and molecular targets |
| topic | prostate cancer natural compounds phytochemicals chemoprevention novel therapeutic strategies |
| url | https://www.mdpi.com/2073-4409/9/2/460 |
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