Recognition memory and DNA damage in undernourished young rats
ABSTRACT This study evaluated the recognition memory and the levels of DNA damage (blood and hippocampus) in undernourished young Wistar rats. The experiment was conducted along 14-week with rodents divided in control group (CG, n=8) and undernourished group (UG, n=12) which was submitted to caloric...
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Academia Brasileira de Ciências
2016-01-01
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| Series: | Anais da Academia Brasileira de Ciências |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016005010111&lng=en&tlng=en |
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| author | PATRÍCIA MOLZ JOEL H. ELLWANGER FERNANDA F. ZENKNER DEIVIS DE CAMPOS DANIEL PRÁ MARISA T.L. PUTZKE SILVIA I.R. FRANKE |
| author_facet | PATRÍCIA MOLZ JOEL H. ELLWANGER FERNANDA F. ZENKNER DEIVIS DE CAMPOS DANIEL PRÁ MARISA T.L. PUTZKE SILVIA I.R. FRANKE |
| author_sort | PATRÍCIA MOLZ |
| collection | DOAJ |
| description | ABSTRACT This study evaluated the recognition memory and the levels of DNA damage (blood and hippocampus) in undernourished young Wistar rats. The experiment was conducted along 14-week with rodents divided in control group (CG, n=8) and undernourished group (UG, n=12) which was submitted to caloric restriction. Nutritional status for undernutrition was defined by Body Mass Index (BMI) ≤0.45g/cm2 and by weighting the organs/tissue (liver, spleen, intestine, peritoneal fat, kidney and encephalon). The Novel Object Recognition Test assessed recognition memory and the Comet Assay evaluated the levels of DNA damage. Student t test, 2-way ANOVA and Pearson's correlation analysis were used and the significance level was of p<0.05. The UG showed lower BMI and organ/tissue weights than CG (p<0.001). In short-term memory, the recognition rate was higher in the UG (p<0.05), only after 4 weeks. In the long-term memory, again recognition rate was higher in the UG than the CG, after 4 weeks (p<0.001) and 14 weeks (p<0.01). The UG showed decreased levels of DNA damage in the blood (p<0.01) and increased levels in the hippocampus (p<0.01). We concluded in this study that the undernutrition by caloric restriction did not cause impairment in recognition memory, however induced DNA damage in the hippocampus. |
| first_indexed | 2024-04-12T00:34:18Z |
| format | Article |
| id | doaj.art-9e5a00d8b08c4531b5745cf7e48e1572 |
| institution | Directory Open Access Journal |
| issn | 1678-2690 |
| language | English |
| last_indexed | 2024-04-12T00:34:18Z |
| publishDate | 2016-01-01 |
| publisher | Academia Brasileira de Ciências |
| record_format | Article |
| series | Anais da Academia Brasileira de Ciências |
| spelling | doaj.art-9e5a00d8b08c4531b5745cf7e48e15722022-12-22T03:55:14ZengAcademia Brasileira de CiênciasAnais da Academia Brasileira de Ciências1678-26902016-01-01010.1590/0001-3765201620150608S0001-37652016005010111Recognition memory and DNA damage in undernourished young ratsPATRÍCIA MOLZJOEL H. ELLWANGERFERNANDA F. ZENKNERDEIVIS DE CAMPOSDANIEL PRÁMARISA T.L. PUTZKESILVIA I.R. FRANKEABSTRACT This study evaluated the recognition memory and the levels of DNA damage (blood and hippocampus) in undernourished young Wistar rats. The experiment was conducted along 14-week with rodents divided in control group (CG, n=8) and undernourished group (UG, n=12) which was submitted to caloric restriction. Nutritional status for undernutrition was defined by Body Mass Index (BMI) ≤0.45g/cm2 and by weighting the organs/tissue (liver, spleen, intestine, peritoneal fat, kidney and encephalon). The Novel Object Recognition Test assessed recognition memory and the Comet Assay evaluated the levels of DNA damage. Student t test, 2-way ANOVA and Pearson's correlation analysis were used and the significance level was of p<0.05. The UG showed lower BMI and organ/tissue weights than CG (p<0.001). In short-term memory, the recognition rate was higher in the UG (p<0.05), only after 4 weeks. In the long-term memory, again recognition rate was higher in the UG than the CG, after 4 weeks (p<0.001) and 14 weeks (p<0.01). The UG showed decreased levels of DNA damage in the blood (p<0.01) and increased levels in the hippocampus (p<0.01). We concluded in this study that the undernutrition by caloric restriction did not cause impairment in recognition memory, however induced DNA damage in the hippocampus.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016005010111&lng=en&tlng=endano no DNAmemóriaestado nutricionaldesnutriçãoratos Wistar |
| spellingShingle | PATRÍCIA MOLZ JOEL H. ELLWANGER FERNANDA F. ZENKNER DEIVIS DE CAMPOS DANIEL PRÁ MARISA T.L. PUTZKE SILVIA I.R. FRANKE Recognition memory and DNA damage in undernourished young rats Anais da Academia Brasileira de Ciências dano no DNA memória estado nutricional desnutrição ratos Wistar |
| title | Recognition memory and DNA damage in undernourished young rats |
| title_full | Recognition memory and DNA damage in undernourished young rats |
| title_fullStr | Recognition memory and DNA damage in undernourished young rats |
| title_full_unstemmed | Recognition memory and DNA damage in undernourished young rats |
| title_short | Recognition memory and DNA damage in undernourished young rats |
| title_sort | recognition memory and dna damage in undernourished young rats |
| topic | dano no DNA memória estado nutricional desnutrição ratos Wistar |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016005010111&lng=en&tlng=en |
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