Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus

Background: Cathepsin L is a member of papain superfamily. It seems to promote T-cell survival, selection maturation in the thymus and enhance the antigen presentation. Cathepsin L plays an important role in tumor necrosis factors (TNF-α) induced cell death. Also it degrades the tight junction betwe...

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Main Authors: Zeinab A El Ashmawy, Amal A El-Ashmawy, Naeim M Abd El-Naby, Hussein M Ghoraba
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Indian Journal of Dermatology
Subjects:
Online Access:http://www.e-ijd.org/article.asp?issn=0019-5154;year=2015;volume=60;issue=1;spage=13;epage=20;aulast=El
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author Zeinab A El Ashmawy
Amal A El-Ashmawy
Naeim M Abd El-Naby
Hussein M Ghoraba
author_facet Zeinab A El Ashmawy
Amal A El-Ashmawy
Naeim M Abd El-Naby
Hussein M Ghoraba
author_sort Zeinab A El Ashmawy
collection DOAJ
description Background: Cathepsin L is a member of papain superfamily. It seems to promote T-cell survival, selection maturation in the thymus and enhance the antigen presentation. Cathepsin L plays an important role in tumor necrosis factors (TNF-α) induced cell death. Also it degrades the tight junction between cornedesomses in the epidermis. Elevated expression of cathepsin L has been found in many inflammatory and neoplastic diseases. Objective: The aim of this study was to determine immunohistochemical expression of cathepsin L in atopic dermatitis (AD) and lichen planus (LP) patients in order to evaluate its role in the pathogenesis of both diseases. Materials and Methods: This study included 15 patients with AD (Group I), 15 patients with LP (Group II), in addition to 10 healthy skin specimens served as controls (Group III). Punch biopsies were taken from lesional skin of the patients and controls for immunohistochemical detection of cathepsin L expression. Results: Highly significant increase was found in cathepsin L expression in AD and LP patients compared to controls [P = 0.001]. Conclusion: Cathepsin L could be implicated as an important protease in the pathogenesis of AD and LP. It could be a useful marker for assessing AD severity.
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spelling doaj.art-9e5a36610e1543e4acba95403968c9a92022-12-21T18:24:32ZengWolters Kluwer Medknow PublicationsIndian Journal of Dermatology0019-51541998-36112015-01-01601132010.4103/0019-5154.147779Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planusZeinab A El AshmawyAmal A El-AshmawyNaeim M Abd El-NabyHussein M GhorabaBackground: Cathepsin L is a member of papain superfamily. It seems to promote T-cell survival, selection maturation in the thymus and enhance the antigen presentation. Cathepsin L plays an important role in tumor necrosis factors (TNF-α) induced cell death. Also it degrades the tight junction between cornedesomses in the epidermis. Elevated expression of cathepsin L has been found in many inflammatory and neoplastic diseases. Objective: The aim of this study was to determine immunohistochemical expression of cathepsin L in atopic dermatitis (AD) and lichen planus (LP) patients in order to evaluate its role in the pathogenesis of both diseases. Materials and Methods: This study included 15 patients with AD (Group I), 15 patients with LP (Group II), in addition to 10 healthy skin specimens served as controls (Group III). Punch biopsies were taken from lesional skin of the patients and controls for immunohistochemical detection of cathepsin L expression. Results: Highly significant increase was found in cathepsin L expression in AD and LP patients compared to controls [P = 0.001]. Conclusion: Cathepsin L could be implicated as an important protease in the pathogenesis of AD and LP. It could be a useful marker for assessing AD severity.http://www.e-ijd.org/article.asp?issn=0019-5154;year=2015;volume=60;issue=1;spage=13;epage=20;aulast=ElAtopic dermatitiscathepsin Llichen planus and proteases
spellingShingle Zeinab A El Ashmawy
Amal A El-Ashmawy
Naeim M Abd El-Naby
Hussein M Ghoraba
Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus
Indian Journal of Dermatology
Atopic dermatitis
cathepsin L
lichen planus and proteases
title Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus
title_full Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus
title_fullStr Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus
title_full_unstemmed Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus
title_short Immunohistochemical expression of cathepsin L in atopic dermatitis and lichen planus
title_sort immunohistochemical expression of cathepsin l in atopic dermatitis and lichen planus
topic Atopic dermatitis
cathepsin L
lichen planus and proteases
url http://www.e-ijd.org/article.asp?issn=0019-5154;year=2015;volume=60;issue=1;spage=13;epage=20;aulast=El
work_keys_str_mv AT zeinabaelashmawy immunohistochemicalexpressionofcathepsinlinatopicdermatitisandlichenplanus
AT amalaelashmawy immunohistochemicalexpressionofcathepsinlinatopicdermatitisandlichenplanus
AT naeimmabdelnaby immunohistochemicalexpressionofcathepsinlinatopicdermatitisandlichenplanus
AT husseinmghoraba immunohistochemicalexpressionofcathepsinlinatopicdermatitisandlichenplanus