Olfaction and Colour Vision: What Can They Tell Us about Parkinson’s Disease?
Parkinson’s disease is a neurodegenerative disorder with the pathological accumulation of alpha synuclein in the brain and peripheral nerve tissue. Early stages of synucleinopathies, often present clinically with rapid eye movement (REM) sleep disorder (RBD). Clinical markers that indicate early pro...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karolinum Press
2018-11-01
|
| Series: | Prague Medical Report |
| Subjects: | |
| Online Access: | https://pmr.lf1.cuni.cz/119/2/0085/ |
| _version_ | 1818139863538466816 |
|---|---|
| author | Irene Dall’Antonia Karel Šonka Petr Dušek |
| author_facet | Irene Dall’Antonia Karel Šonka Petr Dušek |
| author_sort | Irene Dall’Antonia |
| collection | DOAJ |
| description | Parkinson’s disease is a neurodegenerative disorder with the pathological accumulation of alpha synuclein in the brain and peripheral nerve tissue. Early stages of synucleinopathies, often present clinically with rapid eye movement (REM) sleep disorder (RBD). Clinical markers that indicate early progression from RBD to manifest synucleinopathies include abnormal dopamine transporter (DAT) imaging, motor and non-motor symptoms. Despite the high diagnostic strength of DAT imaging and motor abnormalities, they are not the earliest biomarkers. Non-motor signs of neurodegeneration such as colour vision and olfaction abnormalities are detectable by clinical examination as early as 20 years before disease onset. Detailed analysis of olfactory and colour vision dysfunction can provide valuable information regarding brain pathologies, further specifying clinical phenotypes, and giving clues to underlying pathophysiological mechanisms in Parkinson’s disease and related disorders. |
| first_indexed | 2024-12-11T10:34:51Z |
| format | Article |
| id | doaj.art-9e5b6753cf3b4f8093055307d4799abd |
| institution | Directory Open Access Journal |
| issn | 1214-6994 2336-2936 |
| language | English |
| last_indexed | 2024-12-11T10:34:51Z |
| publishDate | 2018-11-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Prague Medical Report |
| spelling | doaj.art-9e5b6753cf3b4f8093055307d4799abd2022-12-22T01:10:44ZengKarolinum PressPrague Medical Report1214-69942336-29362018-11-011192859610.14712/23362936.2018.87641Olfaction and Colour Vision: What Can They Tell Us about Parkinson’s Disease?Irene Dall’AntoniaKarel ŠonkaPetr DušekParkinson’s disease is a neurodegenerative disorder with the pathological accumulation of alpha synuclein in the brain and peripheral nerve tissue. Early stages of synucleinopathies, often present clinically with rapid eye movement (REM) sleep disorder (RBD). Clinical markers that indicate early progression from RBD to manifest synucleinopathies include abnormal dopamine transporter (DAT) imaging, motor and non-motor symptoms. Despite the high diagnostic strength of DAT imaging and motor abnormalities, they are not the earliest biomarkers. Non-motor signs of neurodegeneration such as colour vision and olfaction abnormalities are detectable by clinical examination as early as 20 years before disease onset. Detailed analysis of olfactory and colour vision dysfunction can provide valuable information regarding brain pathologies, further specifying clinical phenotypes, and giving clues to underlying pathophysiological mechanisms in Parkinson’s disease and related disorders.https://pmr.lf1.cuni.cz/119/2/0085/HyposmiaColour visionNeurodegenerationSynuclein |
| spellingShingle | Irene Dall’Antonia Karel Šonka Petr Dušek Olfaction and Colour Vision: What Can They Tell Us about Parkinson’s Disease? Prague Medical Report Hyposmia Colour vision Neurodegeneration Synuclein |
| title | Olfaction and Colour Vision: What Can They Tell Us about Parkinson’s Disease? |
| title_full | Olfaction and Colour Vision: What Can They Tell Us about Parkinson’s Disease? |
| title_fullStr | Olfaction and Colour Vision: What Can They Tell Us about Parkinson’s Disease? |
| title_full_unstemmed | Olfaction and Colour Vision: What Can They Tell Us about Parkinson’s Disease? |
| title_short | Olfaction and Colour Vision: What Can They Tell Us about Parkinson’s Disease? |
| title_sort | olfaction and colour vision what can they tell us about parkinson s disease |
| topic | Hyposmia Colour vision Neurodegeneration Synuclein |
| url | https://pmr.lf1.cuni.cz/119/2/0085/ |
| work_keys_str_mv | AT irenedallantonia olfactionandcolourvisionwhatcantheytellusaboutparkinsonsdisease AT karelsonka olfactionandcolourvisionwhatcantheytellusaboutparkinsonsdisease AT petrdusek olfactionandcolourvisionwhatcantheytellusaboutparkinsonsdisease |