Analysis of Selected Salivary Adipokines and Cytokines in Patients with Obesity—A Pilot Study
Obesity is a chronic, progressive and relapsing disease that produces many adverse health, social and economic effects. The aim of the study was to analyse the concentrations of selected proinflammatory parameters in the saliva of obese and normal body weight individuals. The study included 116 peop...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/4/4145 |
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| author | Lucyna Ostrowska Joanna Smarkusz-Zarzecka Agnieszka Gornowicz Karolina Lendzion Beata Zyśk Damian Pogodziński |
| author_facet | Lucyna Ostrowska Joanna Smarkusz-Zarzecka Agnieszka Gornowicz Karolina Lendzion Beata Zyśk Damian Pogodziński |
| author_sort | Lucyna Ostrowska |
| collection | DOAJ |
| description | Obesity is a chronic, progressive and relapsing disease that produces many adverse health, social and economic effects. The aim of the study was to analyse the concentrations of selected proinflammatory parameters in the saliva of obese and normal body weight individuals. The study included 116 people divided into two groups: the study group (<i>n</i> = 75, subjects with obesity) and the control group (<i>n</i> = 41, individuals with normal body weight). Bioelectrical impedance analysis was performed, and saliva samples were collected from all study participants to determine the concentrations of selected proinflammatory adipokines and cytokines. Statistically significantly higher concentrations of MMP-2, MMP-9 and IL-1β were found in the saliva of obese women compared to women with normal body weight. Furthermore, statistically significantly higher concentrations of MMP-9, IL-6 and resistin were observed in the saliva of obese men compared to men with normal body weight. Higher concentrations of selected proinflammatory cytokines and adipokines were found in the saliva of obese individuals compared to individuals with normal body weight. It is likely that higher concentrations of MMP-2, MMP-9 and IL-1β can be detected in the saliva of obese women compared to non-obese women, while higher concentrations of MMP-9, IL-6 and resistin can be found in the saliva of obese men compared to non-obese men, which suggests that further research to confirm our observations and determine the mechanisms of development of metabolic complications associated with obesity depending on gender is needed. |
| first_indexed | 2024-03-11T08:41:00Z |
| format | Article |
| id | doaj.art-9e5b869836d248fea3858d845cc77ccb |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T08:41:00Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9e5b869836d248fea3858d845cc77ccb2023-11-16T21:10:10ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-02-01244414510.3390/ijms24044145Analysis of Selected Salivary Adipokines and Cytokines in Patients with Obesity—A Pilot StudyLucyna Ostrowska0Joanna Smarkusz-Zarzecka1Agnieszka Gornowicz2Karolina Lendzion3Beata Zyśk4Damian Pogodziński5Department of Dietetics and Clinical Nutrition, Medical University of Bialystok, 15-054 Bialystok, PolandDepartment of Dietetics and Clinical Nutrition, Medical University of Bialystok, 15-054 Bialystok, PolandDepartment of Biotechnology, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Biotechnology, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Dietetics and Clinical Nutrition, Medical University of Bialystok, 15-054 Bialystok, PolandDepartment of Dietetics and Clinical Nutrition, Medical University of Bialystok, 15-054 Bialystok, PolandObesity is a chronic, progressive and relapsing disease that produces many adverse health, social and economic effects. The aim of the study was to analyse the concentrations of selected proinflammatory parameters in the saliva of obese and normal body weight individuals. The study included 116 people divided into two groups: the study group (<i>n</i> = 75, subjects with obesity) and the control group (<i>n</i> = 41, individuals with normal body weight). Bioelectrical impedance analysis was performed, and saliva samples were collected from all study participants to determine the concentrations of selected proinflammatory adipokines and cytokines. Statistically significantly higher concentrations of MMP-2, MMP-9 and IL-1β were found in the saliva of obese women compared to women with normal body weight. Furthermore, statistically significantly higher concentrations of MMP-9, IL-6 and resistin were observed in the saliva of obese men compared to men with normal body weight. Higher concentrations of selected proinflammatory cytokines and adipokines were found in the saliva of obese individuals compared to individuals with normal body weight. It is likely that higher concentrations of MMP-2, MMP-9 and IL-1β can be detected in the saliva of obese women compared to non-obese women, while higher concentrations of MMP-9, IL-6 and resistin can be found in the saliva of obese men compared to non-obese men, which suggests that further research to confirm our observations and determine the mechanisms of development of metabolic complications associated with obesity depending on gender is needed.https://www.mdpi.com/1422-0067/24/4/4145obesitysalivabody compositionproinflammatory cytokinesproinflammatory adipokinesIL-6 |
| spellingShingle | Lucyna Ostrowska Joanna Smarkusz-Zarzecka Agnieszka Gornowicz Karolina Lendzion Beata Zyśk Damian Pogodziński Analysis of Selected Salivary Adipokines and Cytokines in Patients with Obesity—A Pilot Study International Journal of Molecular Sciences obesity saliva body composition proinflammatory cytokines proinflammatory adipokines IL-6 |
| title | Analysis of Selected Salivary Adipokines and Cytokines in Patients with Obesity—A Pilot Study |
| title_full | Analysis of Selected Salivary Adipokines and Cytokines in Patients with Obesity—A Pilot Study |
| title_fullStr | Analysis of Selected Salivary Adipokines and Cytokines in Patients with Obesity—A Pilot Study |
| title_full_unstemmed | Analysis of Selected Salivary Adipokines and Cytokines in Patients with Obesity—A Pilot Study |
| title_short | Analysis of Selected Salivary Adipokines and Cytokines in Patients with Obesity—A Pilot Study |
| title_sort | analysis of selected salivary adipokines and cytokines in patients with obesity a pilot study |
| topic | obesity saliva body composition proinflammatory cytokines proinflammatory adipokines IL-6 |
| url | https://www.mdpi.com/1422-0067/24/4/4145 |
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