Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife Adults
Targeting kinases linked to insulin resistance (IR) and inflammation may help in reducing the risk of type 2 diabetes (T2D) and Alzheimer’s disease (AD) in its early stages. This study aimed to determine whether DHA-rich fish oil supplementation reduces glycogen synthase kinase (GSK-3), which is lin...
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| Format: | Article |
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MDPI AG
2020-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/6/1612 |
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| author | Rohith N. Thota Jessica I. Rosato Tracy L. Burrows Cintia B. Dias Kylie A. Abbott Ralph N. Martins Manohar L. Garg |
| author_facet | Rohith N. Thota Jessica I. Rosato Tracy L. Burrows Cintia B. Dias Kylie A. Abbott Ralph N. Martins Manohar L. Garg |
| author_sort | Rohith N. Thota |
| collection | DOAJ |
| description | Targeting kinases linked to insulin resistance (IR) and inflammation may help in reducing the risk of type 2 diabetes (T2D) and Alzheimer’s disease (AD) in its early stages. This study aimed to determine whether DHA-rich fish oil supplementation reduces glycogen synthase kinase (GSK-3), which is linked to both IR and AD. Baseline and post-intervention plasma samples from 58 adults with abdominal obesity (Age: 51.7 ± 1.7 years, BMI: 31.9 ± 0.8 kg/m<sup>2</sup>) were analysed for outcome measures. Participants were allocated to 2 g DHA-rich fish oil capsules (860 mg DHA + 120 mg EPA) (n = 31) or placebo capsules (n = 27) per day for 12 weeks. Compared to placebo, DHA-rich fish oil significantly reduced GSK-3β by −2.3 ± 0.3 ng/mL. An inverse correlation (<i>p</i> < 0.05) was found between baseline insulin and IR and their changes following intervention only in participants with C-reactive protein levels higher than 2.4 mg/L. DHA-rich fish oil reduces GSK-3 and IR, suggesting a potential role of long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) in ameliorating AD risk. |
| first_indexed | 2024-03-10T19:28:53Z |
| format | Article |
| id | doaj.art-9e5c182f8f3a4b56bdc6ea85f96c6ee7 |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:28:53Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-9e5c182f8f3a4b56bdc6ea85f96c6ee72023-11-20T02:18:41ZengMDPI AGNutrients2072-66432020-05-01126161210.3390/nu12061612Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife AdultsRohith N. Thota0Jessica I. Rosato1Tracy L. Burrows2Cintia B. Dias3Kylie A. Abbott4Ralph N. Martins5Manohar L. Garg6Nutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan NSW 2308, AustraliaNutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan NSW 2308, AustraliaSchool of Health Sciences, University of Newcastle, Callaghan NSW 2308, AustraliaNutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan NSW 2308, AustraliaNutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan NSW 2308, AustraliaDepartment of Biomedical Sciences, Macquarie University, North Ryde NSW 2109, AustraliaNutraceuticals Research Program, School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan NSW 2308, AustraliaTargeting kinases linked to insulin resistance (IR) and inflammation may help in reducing the risk of type 2 diabetes (T2D) and Alzheimer’s disease (AD) in its early stages. This study aimed to determine whether DHA-rich fish oil supplementation reduces glycogen synthase kinase (GSK-3), which is linked to both IR and AD. Baseline and post-intervention plasma samples from 58 adults with abdominal obesity (Age: 51.7 ± 1.7 years, BMI: 31.9 ± 0.8 kg/m<sup>2</sup>) were analysed for outcome measures. Participants were allocated to 2 g DHA-rich fish oil capsules (860 mg DHA + 120 mg EPA) (n = 31) or placebo capsules (n = 27) per day for 12 weeks. Compared to placebo, DHA-rich fish oil significantly reduced GSK-3β by −2.3 ± 0.3 ng/mL. An inverse correlation (<i>p</i> < 0.05) was found between baseline insulin and IR and their changes following intervention only in participants with C-reactive protein levels higher than 2.4 mg/L. DHA-rich fish oil reduces GSK-3 and IR, suggesting a potential role of long-chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) in ameliorating AD risk.https://www.mdpi.com/2072-6643/12/6/1612long-chain omega-3 polyunsaturated fatty acidsdocosahexaenoic acidinsulin resistanceobesityAlzheimer’s diseaseglycogen synthase kinase-3 |
| spellingShingle | Rohith N. Thota Jessica I. Rosato Tracy L. Burrows Cintia B. Dias Kylie A. Abbott Ralph N. Martins Manohar L. Garg Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife Adults Nutrients long-chain omega-3 polyunsaturated fatty acids docosahexaenoic acid insulin resistance obesity Alzheimer’s disease glycogen synthase kinase-3 |
| title | Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife Adults |
| title_full | Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife Adults |
| title_fullStr | Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife Adults |
| title_full_unstemmed | Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife Adults |
| title_short | Docosahexaenoic Acid-Rich Fish Oil Supplementation Reduces Kinase Associated with Insulin Resistance in Overweight and Obese Midlife Adults |
| title_sort | docosahexaenoic acid rich fish oil supplementation reduces kinase associated with insulin resistance in overweight and obese midlife adults |
| topic | long-chain omega-3 polyunsaturated fatty acids docosahexaenoic acid insulin resistance obesity Alzheimer’s disease glycogen synthase kinase-3 |
| url | https://www.mdpi.com/2072-6643/12/6/1612 |
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