Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer
Colorectal cancer (CRC) is one of the most common tumours in developed countries. Although its incidence and mortality rates have decreased, its prognosis has not changed, and a high percentage of patients with CRC develop relapse (metachronous metastasis, MM, or local recurrence, LR) during their d...
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| Format: | Article |
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MDPI AG
2021-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/8/967 |
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| author | María I. Aroca-Siendones Sara Moreno-SanJuan Jose D. Puentes-Pardo Michela Verbeni Javier Arnedo Julia Escudero-Feliu María García-Costela Adelina García-Robles Ángel Carazo Josefa León |
| author_facet | María I. Aroca-Siendones Sara Moreno-SanJuan Jose D. Puentes-Pardo Michela Verbeni Javier Arnedo Julia Escudero-Feliu María García-Costela Adelina García-Robles Ángel Carazo Josefa León |
| author_sort | María I. Aroca-Siendones |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the most common tumours in developed countries. Although its incidence and mortality rates have decreased, its prognosis has not changed, and a high percentage of patients with CRC develop relapse (metachronous metastasis, MM, or local recurrence, LR) during their disease. The identification of these patients is very important for their correct management, but the lack of prognostic markers makes it difficult. Given the connection between circadian disruption and cancer development and progression, we aimed to analyse the prognostic significance of core circadian proteins in CRC. We measured the expression of PER1-3, CRY1-2, BMAL1 and NR1D2 in a cohort of CRC patients by immunohistochemistry (IHC) and analysed their prognostic potential in this disease. A low expression of PER2 and BMAL1 was significantly associated with metastasis at the moment of disease diagnosis, whereas a high expression of CRY1 appeared as an independent prognostic factor of MM development. A high expression of NR1D2 appeared as an independent prognostic factor of LR development after disease diagnosis. Moreover, patients with a low expression of BMAL1 and a high expression of CRY1 showed lower OS and DFS at five years. Although these markers need to be validated in larger and different ethnic cohorts, the simplicity of IHC makes these proteins candidates for personalizing CRC treatment. |
| first_indexed | 2024-03-10T08:59:38Z |
| format | Article |
| id | doaj.art-9e5d61434c8b49debfcdf859c78cd7bf |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T08:59:38Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-9e5d61434c8b49debfcdf859c78cd7bf2023-11-22T06:52:42ZengMDPI AGBiomedicines2227-90592021-08-019896710.3390/biomedicines9080967Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal CancerMaría I. Aroca-Siendones0Sara Moreno-SanJuan1Jose D. Puentes-Pardo2Michela Verbeni3Javier Arnedo4Julia Escudero-Feliu5María García-Costela6Adelina García-Robles7Ángel Carazo8Josefa León9Biobank of the Public Health System of Andalusia, 18016 Granada, SpainCytometry and Microscopy Research Service, Biosanitary Research Institute of Granada (ibs.GRANADA), 18012 Granada, SpainBiosanitary Research Institute of Granada (ibs.GRANADA), 18012 Granada, SpainDepartment of Computer Science and Artificial Intelligence, University of Granada, 18071 Granada, SpainBioinformatics Service, Instituto de Investigación Biosanitaria de Granada, ibs.GRANADA, 18012 Granada, SpainBiosanitary Research Institute of Granada (ibs.GRANADA), 18012 Granada, SpainBiosanitary Research Institute of Granada (ibs.GRANADA), 18012 Granada, SpainBiosanitary Research Institute of Granada (ibs.GRANADA), 18012 Granada, SpainBiosanitary Research Institute of Granada (ibs.GRANADA), 18012 Granada, SpainBiosanitary Research Institute of Granada (ibs.GRANADA), 18012 Granada, SpainColorectal cancer (CRC) is one of the most common tumours in developed countries. Although its incidence and mortality rates have decreased, its prognosis has not changed, and a high percentage of patients with CRC develop relapse (metachronous metastasis, MM, or local recurrence, LR) during their disease. The identification of these patients is very important for their correct management, but the lack of prognostic markers makes it difficult. Given the connection between circadian disruption and cancer development and progression, we aimed to analyse the prognostic significance of core circadian proteins in CRC. We measured the expression of PER1-3, CRY1-2, BMAL1 and NR1D2 in a cohort of CRC patients by immunohistochemistry (IHC) and analysed their prognostic potential in this disease. A low expression of PER2 and BMAL1 was significantly associated with metastasis at the moment of disease diagnosis, whereas a high expression of CRY1 appeared as an independent prognostic factor of MM development. A high expression of NR1D2 appeared as an independent prognostic factor of LR development after disease diagnosis. Moreover, patients with a low expression of BMAL1 and a high expression of CRY1 showed lower OS and DFS at five years. Although these markers need to be validated in larger and different ethnic cohorts, the simplicity of IHC makes these proteins candidates for personalizing CRC treatment.https://www.mdpi.com/2227-9059/9/8/967colorectal cancercore circadian clockmetachronous metastasislocal recurrenceoverall survivaldisease free survival |
| spellingShingle | María I. Aroca-Siendones Sara Moreno-SanJuan Jose D. Puentes-Pardo Michela Verbeni Javier Arnedo Julia Escudero-Feliu María García-Costela Adelina García-Robles Ángel Carazo Josefa León Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer Biomedicines colorectal cancer core circadian clock metachronous metastasis local recurrence overall survival disease free survival |
| title | Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer |
| title_full | Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer |
| title_fullStr | Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer |
| title_full_unstemmed | Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer |
| title_short | Core Circadian Clock Proteins as Biomarkers of Progression in Colorectal Cancer |
| title_sort | core circadian clock proteins as biomarkers of progression in colorectal cancer |
| topic | colorectal cancer core circadian clock metachronous metastasis local recurrence overall survival disease free survival |
| url | https://www.mdpi.com/2227-9059/9/8/967 |
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