Activation of CXCL6/CXCR1/2 Axis Promotes the Growth and Metastasis of Osteosarcoma Cells in vitro and in vivo

Activation of CXCL6/CXCR1/2 Axis Promotes the Growth and Metastasis of Osteosarcoma Cells in vitro and in vivo

Osteosarcoma (OS) is a malignant primary bone tumor with high metastatic rate. C-X-C motif chemokine ligand 6 (CXCL6) and its receptor C-X-C motif chemokine receptor 1/2 (CXCR1/2) have been found to participate in the process of carcinogenesis. In this study, we evaluated the role of CXCL6/CXCR1/2 a...

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Bibliographic Details
Main Authors: Guangchen Liu, Liping An, Hongmei Zhang, Peige Du, Yu Sheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Pharmacology
Subjects:
osteosarcoma
CXCL6/CXCR1/2 axis
metastasis
PI3K/AKT
β-catenin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00307/full

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