Development of Hyperthyroidism Following Primary Hypothyroidism: A Case Report
Development of hyperthyroidism following primary hypothyroidism is uncommon, and only a few documented cases have been reported. Alterations in thyroid-stimulating hormone receptor antibodies in serum are currently considered to play the main role in the pathophysiology, but the exact mechanism is s...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2004-04-01
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| Series: | Kaohsiung Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1607551X09701056 |
| _version_ | 1829473143697178624 |
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| author | Yueh-Hua Chung Horng-Yih Ou Ta-Jen Wu |
| author_facet | Yueh-Hua Chung Horng-Yih Ou Ta-Jen Wu |
| author_sort | Yueh-Hua Chung |
| collection | DOAJ |
| description | Development of hyperthyroidism following primary hypothyroidism is uncommon, and only a few documented cases have been reported. Alterations in thyroid-stimulating hormone receptor antibodies in serum are currently considered to play the main role in the pathophysiology, but the exact mechanism is still unknown. Here, we report the case of a 60-year-old man with disturbed consciousness due to hyponatremia. Thyroid function tests showed primary hypothyroidism with a high anti-microsomal antibody titer (1:6,400). The patient experienced weight loss and exophthalmos 6 years later. Serum thyroid hormone levels were increased and thyroxine treatment was discontinued, but the patient remained thyrotoxic 2 months later. 131I thyroid uptake was 40.9% at 24 hours, and bilateral thyroid lobes were not enlarged with diffuse radioactivity. Six months later, the patient was still thyrotoxic and therapy with methimazole 10 mg/day was started. He is now taking methimazole and is euthyroid. |
| first_indexed | 2024-12-14T02:24:59Z |
| format | Article |
| id | doaj.art-9e63948426084de2a519204d31682432 |
| institution | Directory Open Access Journal |
| issn | 1607-551X |
| language | English |
| last_indexed | 2024-12-14T02:24:59Z |
| publishDate | 2004-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Kaohsiung Journal of Medical Sciences |
| spelling | doaj.art-9e63948426084de2a519204d316824322022-12-21T23:20:24ZengWileyKaohsiung Journal of Medical Sciences1607-551X2004-04-0120418819110.1016/S1607-551X(09)70105-6Development of Hyperthyroidism Following Primary Hypothyroidism: A Case ReportYueh-Hua ChungHorng-Yih OuTa-Jen WuDevelopment of hyperthyroidism following primary hypothyroidism is uncommon, and only a few documented cases have been reported. Alterations in thyroid-stimulating hormone receptor antibodies in serum are currently considered to play the main role in the pathophysiology, but the exact mechanism is still unknown. Here, we report the case of a 60-year-old man with disturbed consciousness due to hyponatremia. Thyroid function tests showed primary hypothyroidism with a high anti-microsomal antibody titer (1:6,400). The patient experienced weight loss and exophthalmos 6 years later. Serum thyroid hormone levels were increased and thyroxine treatment was discontinued, but the patient remained thyrotoxic 2 months later. 131I thyroid uptake was 40.9% at 24 hours, and bilateral thyroid lobes were not enlarged with diffuse radioactivity. Six months later, the patient was still thyrotoxic and therapy with methimazole 10 mg/day was started. He is now taking methimazole and is euthyroid.http://www.sciencedirect.com/science/article/pii/S1607551X09701056hyperthyroidismhypothyroidismGraves' disease |
| spellingShingle | Yueh-Hua Chung Horng-Yih Ou Ta-Jen Wu Development of Hyperthyroidism Following Primary Hypothyroidism: A Case Report Kaohsiung Journal of Medical Sciences hyperthyroidism hypothyroidism Graves' disease |
| title | Development of Hyperthyroidism Following Primary Hypothyroidism: A Case Report |
| title_full | Development of Hyperthyroidism Following Primary Hypothyroidism: A Case Report |
| title_fullStr | Development of Hyperthyroidism Following Primary Hypothyroidism: A Case Report |
| title_full_unstemmed | Development of Hyperthyroidism Following Primary Hypothyroidism: A Case Report |
| title_short | Development of Hyperthyroidism Following Primary Hypothyroidism: A Case Report |
| title_sort | development of hyperthyroidism following primary hypothyroidism a case report |
| topic | hyperthyroidism hypothyroidism Graves' disease |
| url | http://www.sciencedirect.com/science/article/pii/S1607551X09701056 |
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