Occult primary breast cancer and cognates: Atypical today's cases inside a centenarian history
Occult breast cancer (OBC) is a rare entity and, to date, still represents a diagnostic and therapeutic challenge. OBC is often diagnosed as metastatic dissemination without a recognized primary; this delay in diagnosis and the known increased tumor aggressiveness can condition treatment choices and...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Current Problems in Cancer: Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666621922000552 |
| _version_ | 1811178648035655680 |
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| author | Liliana Montella Vittorio Riccio Raffaella Ruocco Luigi Di Marino Annamaria Ambrosino Antonio Capuozzo Carminia-Maria Della Corte Arianna Esposito Paola Coppola Carmela Liguori Gaetano Facchini Andrea Ronchi Angela Ruggiero |
| author_facet | Liliana Montella Vittorio Riccio Raffaella Ruocco Luigi Di Marino Annamaria Ambrosino Antonio Capuozzo Carminia-Maria Della Corte Arianna Esposito Paola Coppola Carmela Liguori Gaetano Facchini Andrea Ronchi Angela Ruggiero |
| author_sort | Liliana Montella |
| collection | DOAJ |
| description | Occult breast cancer (OBC) is a rare entity and, to date, still represents a diagnostic and therapeutic challenge. OBC is often diagnosed as metastatic dissemination without a recognized primary; this delay in diagnosis and the known increased tumor aggressiveness can condition treatment choices and patients’ outcomes. In this report, we describe three atypical presentations of breast cancer. The first corresponds to an OBC with axillary lymphadenopathy which is the most frequent finding in the literature. Another one describes diffuse bone metastases from breast tumors diagnosed through bone biopsy without any primitive breast lesion with all applied radiological imaging. The third one is instead an overt breast cancer with a pathological profile of a low aggressive tumor showing bulky lung involvement. The first OBC description dated back to Halstead's description in 1907 and represents a little-explored niche which however should be nowadays studied to define biological determinants probably influencing a different presentation and behavior |
| first_indexed | 2024-04-11T06:23:12Z |
| format | Article |
| id | doaj.art-9e664e5898ee4b708b7af87c5df70bf8 |
| institution | Directory Open Access Journal |
| issn | 2666-6219 |
| language | English |
| last_indexed | 2024-04-11T06:23:12Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Problems in Cancer: Case Reports |
| spelling | doaj.art-9e664e5898ee4b708b7af87c5df70bf82022-12-22T04:40:31ZengElsevierCurrent Problems in Cancer: Case Reports2666-62192022-12-018100191Occult primary breast cancer and cognates: Atypical today's cases inside a centenarian historyLiliana Montella0Vittorio Riccio1Raffaella Ruocco2Luigi Di Marino3Annamaria Ambrosino4Antonio Capuozzo5Carminia-Maria Della Corte6Arianna Esposito7Paola Coppola8Carmela Liguori9Gaetano Facchini10Andrea Ronchi11Angela Ruggiero12Oncology Operative Unit, “Santa Maria delle Grazie” Hospital, Ospedale, ASL NA2 NORD, Pozzuoli, Naples 80078, Italy; Corresponding author.Department of Clinical Medicine and Surgery, Università degli Studi di Napoli ''Federico II'', Naples 80131, ItalyMedical Oncology, AORN Cardarelli, Naples 80131, ItalyVilla Dei Fiori, Acerra, Naples 80011, ItalyInternal Medicine Operative Unit, “Santa Maria delle Grazie” Hospital, ASL NA2 NORD, Pozzuoli, Naples 80078, ItalyPneumology Operative Unit, “Mauro Scarlato” Scafati Hospital, ASL Salerno, Scafati 84018, ItalyDepartment of Precision Medicine, Division of Medical Oncology, “Luigi Vanvitelli” University of Campania, Naples 80131, ItalyOncology Operative Unit, “Santa Maria delle Grazie” Hospital, Ospedale, ASL NA2 NORD, Pozzuoli, Naples 80078, ItalyOncology Operative Unit, “Santa Maria delle Grazie” Hospital, Ospedale, ASL NA2 NORD, Pozzuoli, Naples 80078, ItalyOncology Operative Unit, “Santa Maria delle Grazie” Hospital, Ospedale, ASL NA2 NORD, Pozzuoli, Naples 80078, ItalyOncology Operative Unit, “Santa Maria delle Grazie” Hospital, Ospedale, ASL NA2 NORD, Pozzuoli, Naples 80078, ItalyDepartment of Mental and Physical Health and Preventive Medicine, Pathology Unit, University of Campania ''Luigi Vanvitelli'', Naples, ItalyOncology Operative Unit, “Santa Maria delle Grazie” Hospital, Ospedale, ASL NA2 NORD, Pozzuoli, Naples 80078, ItalyOccult breast cancer (OBC) is a rare entity and, to date, still represents a diagnostic and therapeutic challenge. OBC is often diagnosed as metastatic dissemination without a recognized primary; this delay in diagnosis and the known increased tumor aggressiveness can condition treatment choices and patients’ outcomes. In this report, we describe three atypical presentations of breast cancer. The first corresponds to an OBC with axillary lymphadenopathy which is the most frequent finding in the literature. Another one describes diffuse bone metastases from breast tumors diagnosed through bone biopsy without any primitive breast lesion with all applied radiological imaging. The third one is instead an overt breast cancer with a pathological profile of a low aggressive tumor showing bulky lung involvement. The first OBC description dated back to Halstead's description in 1907 and represents a little-explored niche which however should be nowadays studied to define biological determinants probably influencing a different presentation and behaviorhttp://www.sciencedirect.com/science/article/pii/S2666621922000552Occult breast cancerCancer of unknown primaryBone metastasesLymphnode metastases |
| spellingShingle | Liliana Montella Vittorio Riccio Raffaella Ruocco Luigi Di Marino Annamaria Ambrosino Antonio Capuozzo Carminia-Maria Della Corte Arianna Esposito Paola Coppola Carmela Liguori Gaetano Facchini Andrea Ronchi Angela Ruggiero Occult primary breast cancer and cognates: Atypical today's cases inside a centenarian history Current Problems in Cancer: Case Reports Occult breast cancer Cancer of unknown primary Bone metastases Lymphnode metastases |
| title | Occult primary breast cancer and cognates: Atypical today's cases inside a centenarian history |
| title_full | Occult primary breast cancer and cognates: Atypical today's cases inside a centenarian history |
| title_fullStr | Occult primary breast cancer and cognates: Atypical today's cases inside a centenarian history |
| title_full_unstemmed | Occult primary breast cancer and cognates: Atypical today's cases inside a centenarian history |
| title_short | Occult primary breast cancer and cognates: Atypical today's cases inside a centenarian history |
| title_sort | occult primary breast cancer and cognates atypical today s cases inside a centenarian history |
| topic | Occult breast cancer Cancer of unknown primary Bone metastases Lymphnode metastases |
| url | http://www.sciencedirect.com/science/article/pii/S2666621922000552 |
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