Impact of glyphosate (RoundupTM) on the composition and functionality of the gut microbiome
ABSTRACTGlyphosate, the active ingredient in the broad-spectrum herbicide RoundupTM, has been a topic of discussion for decades due to contradictory reports of the effect of glyphosate on human health. Glyphosate inhibits the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) of the shikimic...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Gut Microbes |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2023.2263935 |
| _version_ | 1797320570764787712 |
|---|---|
| author | Lauren Walsh Colin Hill R. Paul Ross |
| author_facet | Lauren Walsh Colin Hill R. Paul Ross |
| author_sort | Lauren Walsh |
| collection | DOAJ |
| description | ABSTRACTGlyphosate, the active ingredient in the broad-spectrum herbicide RoundupTM, has been a topic of discussion for decades due to contradictory reports of the effect of glyphosate on human health. Glyphosate inhibits the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) of the shikimic pathway producing aromatic amino acids in plants, a mechanism that suggests that the herbicide would not affect humans as this pathway is not found in mammals. However, numerous studies have implicated glyphosate exposure in the manifestation of a variety of disorders in the human body. This review specifically outlines the potential effect of glyphosate exposure on the composition and functionality of the gut microbiome. Evidence has been building behind the hypothesis that the composition of each individual gut microbiota significantly impacts health. For this reason, the potential of glyphosate to inhibit the growth of beneficial microbes in the gut or alter their functionality is an important topic that warrants further consideration. |
| first_indexed | 2024-03-08T04:41:06Z |
| format | Article |
| id | doaj.art-9e6779be9836441e985ca6eb0bc1a186 |
| institution | Directory Open Access Journal |
| issn | 1949-0976 1949-0984 |
| language | English |
| last_indexed | 2024-03-08T04:41:06Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj.art-9e6779be9836441e985ca6eb0bc1a1862024-02-08T12:02:07ZengTaylor & Francis GroupGut Microbes1949-09761949-09842023-12-0115210.1080/19490976.2023.2263935Impact of glyphosate (RoundupTM) on the composition and functionality of the gut microbiomeLauren Walsh0Colin Hill1R. Paul Ross2APC Microbiome Ireland, University College Cork, Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandAPC Microbiome Ireland, University College Cork, Cork, IrelandABSTRACTGlyphosate, the active ingredient in the broad-spectrum herbicide RoundupTM, has been a topic of discussion for decades due to contradictory reports of the effect of glyphosate on human health. Glyphosate inhibits the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) of the shikimic pathway producing aromatic amino acids in plants, a mechanism that suggests that the herbicide would not affect humans as this pathway is not found in mammals. However, numerous studies have implicated glyphosate exposure in the manifestation of a variety of disorders in the human body. This review specifically outlines the potential effect of glyphosate exposure on the composition and functionality of the gut microbiome. Evidence has been building behind the hypothesis that the composition of each individual gut microbiota significantly impacts health. For this reason, the potential of glyphosate to inhibit the growth of beneficial microbes in the gut or alter their functionality is an important topic that warrants further consideration.https://www.tandfonline.com/doi/10.1080/19490976.2023.2263935Glyphosategut microbiomeantimicrobialhuman healthRoundupTM |
| spellingShingle | Lauren Walsh Colin Hill R. Paul Ross Impact of glyphosate (RoundupTM) on the composition and functionality of the gut microbiome Gut Microbes Glyphosate gut microbiome antimicrobial human health RoundupTM |
| title | Impact of glyphosate (RoundupTM) on the composition and functionality of the gut microbiome |
| title_full | Impact of glyphosate (RoundupTM) on the composition and functionality of the gut microbiome |
| title_fullStr | Impact of glyphosate (RoundupTM) on the composition and functionality of the gut microbiome |
| title_full_unstemmed | Impact of glyphosate (RoundupTM) on the composition and functionality of the gut microbiome |
| title_short | Impact of glyphosate (RoundupTM) on the composition and functionality of the gut microbiome |
| title_sort | impact of glyphosate rounduptm on the composition and functionality of the gut microbiome |
| topic | Glyphosate gut microbiome antimicrobial human health RoundupTM |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2023.2263935 |
| work_keys_str_mv | AT laurenwalsh impactofglyphosaterounduptmonthecompositionandfunctionalityofthegutmicrobiome AT colinhill impactofglyphosaterounduptmonthecompositionandfunctionalityofthegutmicrobiome AT rpaulross impactofglyphosaterounduptmonthecompositionandfunctionalityofthegutmicrobiome |