Role of diffusion weighted MR imaging in characterization of focal kidney and upper urinary tract lesions
Previous studies suggested that the apparent diffusion coefficient (ADC) value could help in the differentiation and characterization of the benign and malignant renal masses.However, there is still wide overlap in the ADC values between the benign and malignant tumors. Objectives: To retrospectivel...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2016-12-01
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| Series: | The Egyptian Journal of Radiology and Nuclear Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0378603X16301723 |
| _version_ | 1819176989499588608 |
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| author | Donia M. Sobh, MBBch, MD Prof.Dr. Galal El Sayed Magdy El Hawary, MBBch, MD Prof.Dr. Mohamed Abou El Ghar, MBBch, MD Prof.Dr. Tarek Abd El Moneim El-Diasty Prof.Dr. Magdy El-Sayed Settein Dr. Shereen ElShaer Prof.Dr. Mohamed Salah Ebrahim Tantawy |
| author_facet | Donia M. Sobh, MBBch, MD Prof.Dr. Galal El Sayed Magdy El Hawary, MBBch, MD Prof.Dr. Mohamed Abou El Ghar, MBBch, MD Prof.Dr. Tarek Abd El Moneim El-Diasty Prof.Dr. Magdy El-Sayed Settein Dr. Shereen ElShaer Prof.Dr. Mohamed Salah Ebrahim Tantawy |
| author_sort | Donia M. Sobh, MBBch, MD |
| collection | DOAJ |
| description | Previous studies suggested that the apparent diffusion coefficient (ADC) value could help in the differentiation and characterization of the benign and malignant renal masses.However, there is still wide overlap in the ADC values between the benign and malignant tumors.
Objectives: To retrospectively assess the usefulness of the diffusion weighted imaging (DWI) for the characterization and differentiation between benign and malignant renal masses.
Methods: A total of 87 renal and/or upper ureteric masses were included in our study. The signal intensity of the lesions was assessed on both the DWI and ADC map and the ADC value was calculated. t test, ANOVA test and Receiver operating characteristic (ROC) curve analysis were performed.
Results: The ADC values of benign lesions were significantly higher than those of the malignant masses [3.2 versus 1.3 × 10−3 mm2/s], Median, P < 0.0001.The sensitivity and specificity of the DWI for the differentiation of benign and malignant masses were 98% and 73% using an ADC cutoffvalue of 2.2. Clear cell renal cell carcinoma demonstrates higher ADC value than non clear cell RCC.
Conclusion: DWI-MRI has a role in differentiation of benign and malignant renal masses and the characterization of different malignant categories, subtypes and grades. |
| first_indexed | 2024-12-22T21:19:31Z |
| format | Article |
| id | doaj.art-9e67da0db76044508134f3e047a5b459 |
| institution | Directory Open Access Journal |
| issn | 0378-603X |
| language | English |
| last_indexed | 2024-12-22T21:19:31Z |
| publishDate | 2016-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | The Egyptian Journal of Radiology and Nuclear Medicine |
| spelling | doaj.art-9e67da0db76044508134f3e047a5b4592022-12-21T18:12:14ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine0378-603X2016-12-014741689170010.1016/j.ejrnm.2016.09.006Role of diffusion weighted MR imaging in characterization of focal kidney and upper urinary tract lesionsDonia M. Sobh, MBBch, MD0Prof.Dr. Galal El Sayed Magdy El Hawary, MBBch, MD1Prof.Dr. Mohamed Abou El Ghar, MBBch, MD2Prof.Dr. Tarek Abd El Moneim El-Diasty3Prof.Dr. Magdy El-Sayed Settein4Dr. Shereen ElShaer5Prof.Dr. Mohamed Salah Ebrahim Tantawy6Diagnostic Radiology, Faculty of Medicine, Mansoura University, EgyptDiagnostic Radiology, Faculty of Medicine, Mansoura University, EgyptDiagnostic Radiology Urology and Nephrology Center, EgyptDiagnostic Radiology Urology and Nephrology Center, EgyptDiagnostic Radiology, Faculty of Medicine, Mansoura University, EgyptPublic Health and Community Medicine, EgyptDiagnostic Radiology, Faculty of Medicine, Mansoura University, EgyptPrevious studies suggested that the apparent diffusion coefficient (ADC) value could help in the differentiation and characterization of the benign and malignant renal masses.However, there is still wide overlap in the ADC values between the benign and malignant tumors. Objectives: To retrospectively assess the usefulness of the diffusion weighted imaging (DWI) for the characterization and differentiation between benign and malignant renal masses. Methods: A total of 87 renal and/or upper ureteric masses were included in our study. The signal intensity of the lesions was assessed on both the DWI and ADC map and the ADC value was calculated. t test, ANOVA test and Receiver operating characteristic (ROC) curve analysis were performed. Results: The ADC values of benign lesions were significantly higher than those of the malignant masses [3.2 versus 1.3 × 10−3 mm2/s], Median, P < 0.0001.The sensitivity and specificity of the DWI for the differentiation of benign and malignant masses were 98% and 73% using an ADC cutoffvalue of 2.2. Clear cell renal cell carcinoma demonstrates higher ADC value than non clear cell RCC. Conclusion: DWI-MRI has a role in differentiation of benign and malignant renal masses and the characterization of different malignant categories, subtypes and grades.http://www.sciencedirect.com/science/article/pii/S0378603X16301723Diffusion weighted MRIRenal massTCCRCCADC |
| spellingShingle | Donia M. Sobh, MBBch, MD Prof.Dr. Galal El Sayed Magdy El Hawary, MBBch, MD Prof.Dr. Mohamed Abou El Ghar, MBBch, MD Prof.Dr. Tarek Abd El Moneim El-Diasty Prof.Dr. Magdy El-Sayed Settein Dr. Shereen ElShaer Prof.Dr. Mohamed Salah Ebrahim Tantawy Role of diffusion weighted MR imaging in characterization of focal kidney and upper urinary tract lesions The Egyptian Journal of Radiology and Nuclear Medicine Diffusion weighted MRI Renal mass TCC RCC ADC |
| title | Role of diffusion weighted MR imaging in characterization of focal kidney and upper urinary tract lesions |
| title_full | Role of diffusion weighted MR imaging in characterization of focal kidney and upper urinary tract lesions |
| title_fullStr | Role of diffusion weighted MR imaging in characterization of focal kidney and upper urinary tract lesions |
| title_full_unstemmed | Role of diffusion weighted MR imaging in characterization of focal kidney and upper urinary tract lesions |
| title_short | Role of diffusion weighted MR imaging in characterization of focal kidney and upper urinary tract lesions |
| title_sort | role of diffusion weighted mr imaging in characterization of focal kidney and upper urinary tract lesions |
| topic | Diffusion weighted MRI Renal mass TCC RCC ADC |
| url | http://www.sciencedirect.com/science/article/pii/S0378603X16301723 |
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