High-Dose Deltamethrin Induces Developmental Toxicity in <i>Caenorhabditis elegans</i> via IRE-1
Deltamethrin (DM), a Type II pyrethroid, is widely used worldwide in agriculture, household applications, and medicine. Recent studies have shown that DM exerts a variety of toxic effects on organs such as the kidney, heart muscle, and nerves in animals. However, little is known about the effects of...
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MDPI AG
2023-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/17/6303 |
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| author | Chuhong Chen Ying Deng Linyan Liu Zhenyan Zou Chenzhong Jin Zhiyin Chen Shuanghui Wang |
| author_facet | Chuhong Chen Ying Deng Linyan Liu Zhenyan Zou Chenzhong Jin Zhiyin Chen Shuanghui Wang |
| author_sort | Chuhong Chen |
| collection | DOAJ |
| description | Deltamethrin (DM), a Type II pyrethroid, is widely used worldwide in agriculture, household applications, and medicine. Recent studies have shown that DM exerts a variety of toxic effects on organs such as the kidney, heart muscle, and nerves in animals. However, little is known about the effects of high-dose DM on growth and development, and the mechanism of toxicity remains unclear. Using the <i>Caenorhabditis elegans</i> model, we found that high-dose DM caused a delay in nematode development. Our results showed that high-dose DM reduced the activation of the endoplasmic reticulum unfolded protein response (UPR<sup>ER</sup>). Further studies revealed that high-dose DM-induced developmental toxicity and reduced capacity for UPR<sup>ER</sup> activation were associated with the IRE-1/XBP-1 pathway. Our results provide new evidence for the developmental toxicity of DM and new insights into the mechanism of DM toxicity. |
| first_indexed | 2024-03-10T23:17:36Z |
| format | Article |
| id | doaj.art-9e67e550a9a04b3d91057a2bdb32b515 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T23:17:36Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-9e67e550a9a04b3d91057a2bdb32b5152023-11-19T08:34:07ZengMDPI AGMolecules1420-30492023-08-012817630310.3390/molecules28176303High-Dose Deltamethrin Induces Developmental Toxicity in <i>Caenorhabditis elegans</i> via IRE-1Chuhong Chen0Ying Deng1Linyan Liu2Zhenyan Zou3Chenzhong Jin4Zhiyin Chen5Shuanghui Wang6Key Laboratory of Green Control of Crop Pests in Hunan Higher Education, Hunan University of Humanities Science and Technology, Loudi 417000, ChinaKey Laboratory of Green Control of Crop Pests in Hunan Higher Education, Hunan University of Humanities Science and Technology, Loudi 417000, ChinaKey Laboratory of Green Control of Crop Pests in Hunan Higher Education, Hunan University of Humanities Science and Technology, Loudi 417000, ChinaCollaborative Innovation Center for Farmland Weeds Control Techniques and Application of Hunan Province, Hunan University of Humanities Science and Technology, Loudi 417000, ChinaKey Laboratory of Green Control of Crop Pests in Hunan Higher Education, Hunan University of Humanities Science and Technology, Loudi 417000, ChinaCollaborative Innovation Center for Farmland Weeds Control Techniques and Application of Hunan Province, Hunan University of Humanities Science and Technology, Loudi 417000, ChinaKey Laboratory of Green Control of Crop Pests in Hunan Higher Education, Hunan University of Humanities Science and Technology, Loudi 417000, ChinaDeltamethrin (DM), a Type II pyrethroid, is widely used worldwide in agriculture, household applications, and medicine. Recent studies have shown that DM exerts a variety of toxic effects on organs such as the kidney, heart muscle, and nerves in animals. However, little is known about the effects of high-dose DM on growth and development, and the mechanism of toxicity remains unclear. Using the <i>Caenorhabditis elegans</i> model, we found that high-dose DM caused a delay in nematode development. Our results showed that high-dose DM reduced the activation of the endoplasmic reticulum unfolded protein response (UPR<sup>ER</sup>). Further studies revealed that high-dose DM-induced developmental toxicity and reduced capacity for UPR<sup>ER</sup> activation were associated with the IRE-1/XBP-1 pathway. Our results provide new evidence for the developmental toxicity of DM and new insights into the mechanism of DM toxicity.https://www.mdpi.com/1420-3049/28/17/6303deltamethrin<i>Caenorhabditis elegans</i>developmenttoxicityendoplasmic reticulum unfolded protein response |
| spellingShingle | Chuhong Chen Ying Deng Linyan Liu Zhenyan Zou Chenzhong Jin Zhiyin Chen Shuanghui Wang High-Dose Deltamethrin Induces Developmental Toxicity in <i>Caenorhabditis elegans</i> via IRE-1 Molecules deltamethrin <i>Caenorhabditis elegans</i> development toxicity endoplasmic reticulum unfolded protein response |
| title | High-Dose Deltamethrin Induces Developmental Toxicity in <i>Caenorhabditis elegans</i> via IRE-1 |
| title_full | High-Dose Deltamethrin Induces Developmental Toxicity in <i>Caenorhabditis elegans</i> via IRE-1 |
| title_fullStr | High-Dose Deltamethrin Induces Developmental Toxicity in <i>Caenorhabditis elegans</i> via IRE-1 |
| title_full_unstemmed | High-Dose Deltamethrin Induces Developmental Toxicity in <i>Caenorhabditis elegans</i> via IRE-1 |
| title_short | High-Dose Deltamethrin Induces Developmental Toxicity in <i>Caenorhabditis elegans</i> via IRE-1 |
| title_sort | high dose deltamethrin induces developmental toxicity in i caenorhabditis elegans i via ire 1 |
| topic | deltamethrin <i>Caenorhabditis elegans</i> development toxicity endoplasmic reticulum unfolded protein response |
| url | https://www.mdpi.com/1420-3049/28/17/6303 |
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