High dietary consumption of iodine induced thyroid cytotoxicity in diabetic intoxicated rats and oxidonitrergic stress in non-diabetic rats
This study aimed to investigate the role of iodine intake in thyroid function ofdiabetic rats. Twenty-four (24) male Wistar rats were placed into four groups (n=6): Group (non-diabetic without iodine), Group 2 (non-diabetic + iodine), Group 3 (diabetic without iodine) and Group 4 (diabetic + iodin...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Prince of Songkla University
2023-02-01
|
| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | https://sjst.psu.ac.th/journal/45-1/17.pdf |
| _version_ | 1797665889998340096 |
|---|---|
| author | Queen Eiza Bisi Ozegbe Oyovwi Mega Obukohwo Gideon Nimedia Aitokhuehi Adesoji Adedipe Fasanmade Lawrence Dayo Adedayo Onome Bright Oghenetega |
| author_facet | Queen Eiza Bisi Ozegbe Oyovwi Mega Obukohwo Gideon Nimedia Aitokhuehi Adesoji Adedipe Fasanmade Lawrence Dayo Adedayo Onome Bright Oghenetega |
| author_sort | Queen Eiza Bisi Ozegbe |
| collection | DOAJ |
| description | This study aimed to investigate the role of iodine intake in thyroid function ofdiabetic rats. Twenty-four (24) male
Wistar rats were placed into four groups (n=6): Group (non-diabetic without iodine), Group 2 (non-diabetic + iodine), Group 3
(diabetic without iodine) and Group 4 (diabetic + iodine). 10mg/kg bw of iodine were mixed with the feeds. Serum
triodothyronine (T3), thyroxine (T4), Thyroid Stimulating Hormone (TSH), thyroglobulin and thyroperoxidase antibodies were
assessed using ELISA. Serum MDA, SOD, and NO levels were assessed with spectrophotometry. In the diabetic rats, lower
mean serum T4 and TSH concentrations were observed (T4: 13.16±0.55 Vs 11.75±0.21 mg/dL, TSH: 2.62±0.11 Vs 2.28±0.08
IU/mL). Iodine treatment further reduced T4 and increased TSH concentrations (T4: 11.75±0.21 vs 6.75±0.22 mg/dL, TSH:
2.28±0.08 Vs 3.08±0.15 IU/mL). Thyroglobulin and thyroperoxidase antibodies were absent in all the rats. It was also observed
that iodine intake caused an increase in oxidative stress in both diabetic and non-diabetic treated rats (MDA; 18.4±1.3 Vs
22.2±2.7 μmol/l X 10-5, NO; 14.08±0.38 Vs 13.24±0.07μm/l) and increased SOD levels in diabetic rats (44.44±2.94 Vs
68.94±0.91 mg/ml); this increase could be due to the increased TSH. Consumption of excess iodine suppressed thyroid function
in diabetic rats and induced oxidative stress in both diabetic and non-diabetic treated rats.
|
| first_indexed | 2024-03-11T19:50:37Z |
| format | Article |
| id | doaj.art-9e68659d8ae8426ba9c5416ecc0a5e56 |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-03-11T19:50:37Z |
| publishDate | 2023-02-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-9e68659d8ae8426ba9c5416ecc0a5e562023-10-05T09:47:16ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952023-02-01451131137High dietary consumption of iodine induced thyroid cytotoxicity in diabetic intoxicated rats and oxidonitrergic stress in non-diabetic ratsQueen Eiza Bisi Ozegbe0Oyovwi Mega Obukohwo1Gideon Nimedia Aitokhuehi2Adesoji Adedipe Fasanmade3Lawrence Dayo Adedayo4Onome Bright Oghenetega5Department of Human Physiology, Faculty of Basic Medical Sciences, Baze University, Abuja, NigeriaDepartment of Physiology, Faculty of Basic Sciences, Adeleke University, Ede, Osun State, NigeriaDepartment of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Oyo State, NigeriaDepartment of Physiology, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Oyo State, NigeriaDepartment of Physiology, College of Health Sciences, Bowen University, Iwo, Osun State, NigeriaDepartment of Physiology, School of Basic Medical Science, Babcock University, Illisan-Ogun State, NigeriaThis study aimed to investigate the role of iodine intake in thyroid function ofdiabetic rats. Twenty-four (24) male Wistar rats were placed into four groups (n=6): Group (non-diabetic without iodine), Group 2 (non-diabetic + iodine), Group 3 (diabetic without iodine) and Group 4 (diabetic + iodine). 10mg/kg bw of iodine were mixed with the feeds. Serum triodothyronine (T3), thyroxine (T4), Thyroid Stimulating Hormone (TSH), thyroglobulin and thyroperoxidase antibodies were assessed using ELISA. Serum MDA, SOD, and NO levels were assessed with spectrophotometry. In the diabetic rats, lower mean serum T4 and TSH concentrations were observed (T4: 13.16±0.55 Vs 11.75±0.21 mg/dL, TSH: 2.62±0.11 Vs 2.28±0.08 IU/mL). Iodine treatment further reduced T4 and increased TSH concentrations (T4: 11.75±0.21 vs 6.75±0.22 mg/dL, TSH: 2.28±0.08 Vs 3.08±0.15 IU/mL). Thyroglobulin and thyroperoxidase antibodies were absent in all the rats. It was also observed that iodine intake caused an increase in oxidative stress in both diabetic and non-diabetic treated rats (MDA; 18.4±1.3 Vs 22.2±2.7 μmol/l X 10-5, NO; 14.08±0.38 Vs 13.24±0.07μm/l) and increased SOD levels in diabetic rats (44.44±2.94 Vs 68.94±0.91 mg/ml); this increase could be due to the increased TSH. Consumption of excess iodine suppressed thyroid function in diabetic rats and induced oxidative stress in both diabetic and non-diabetic treated rats. https://sjst.psu.ac.th/journal/45-1/17.pdfiodine supplementationdiabetesoxidative stressthyroid function |
| spellingShingle | Queen Eiza Bisi Ozegbe Oyovwi Mega Obukohwo Gideon Nimedia Aitokhuehi Adesoji Adedipe Fasanmade Lawrence Dayo Adedayo Onome Bright Oghenetega High dietary consumption of iodine induced thyroid cytotoxicity in diabetic intoxicated rats and oxidonitrergic stress in non-diabetic rats Songklanakarin Journal of Science and Technology (SJST) iodine supplementation diabetes oxidative stress thyroid function |
| title | High dietary consumption of iodine induced thyroid cytotoxicity in diabetic intoxicated rats and oxidonitrergic stress in non-diabetic rats |
| title_full | High dietary consumption of iodine induced thyroid cytotoxicity in diabetic intoxicated rats and oxidonitrergic stress in non-diabetic rats |
| title_fullStr | High dietary consumption of iodine induced thyroid cytotoxicity in diabetic intoxicated rats and oxidonitrergic stress in non-diabetic rats |
| title_full_unstemmed | High dietary consumption of iodine induced thyroid cytotoxicity in diabetic intoxicated rats and oxidonitrergic stress in non-diabetic rats |
| title_short | High dietary consumption of iodine induced thyroid cytotoxicity in diabetic intoxicated rats and oxidonitrergic stress in non-diabetic rats |
| title_sort | high dietary consumption of iodine induced thyroid cytotoxicity in diabetic intoxicated rats and oxidonitrergic stress in non diabetic rats |
| topic | iodine supplementation diabetes oxidative stress thyroid function |
| url | https://sjst.psu.ac.th/journal/45-1/17.pdf |
| work_keys_str_mv | AT queeneizabisiozegbe highdietaryconsumptionofiodineinducedthyroidcytotoxicityindiabeticintoxicatedratsandoxidonitrergicstressinnondiabeticrats AT oyovwimegaobukohwo highdietaryconsumptionofiodineinducedthyroidcytotoxicityindiabeticintoxicatedratsandoxidonitrergicstressinnondiabeticrats AT gideonnimediaaitokhuehi highdietaryconsumptionofiodineinducedthyroidcytotoxicityindiabeticintoxicatedratsandoxidonitrergicstressinnondiabeticrats AT adesojiadedipefasanmade highdietaryconsumptionofiodineinducedthyroidcytotoxicityindiabeticintoxicatedratsandoxidonitrergicstressinnondiabeticrats AT lawrencedayoadedayo highdietaryconsumptionofiodineinducedthyroidcytotoxicityindiabeticintoxicatedratsandoxidonitrergicstressinnondiabeticrats AT onomebrightoghenetega highdietaryconsumptionofiodineinducedthyroidcytotoxicityindiabeticintoxicatedratsandoxidonitrergicstressinnondiabeticrats |