Age-Dependent Association of Height Loss with Incident Fracture Risk in Postmenopausal Korean Women
Background Height loss is a simple clinical measure associated with increased fracture risk. However, limited data exists on the association between height loss and fracture risk in postmenopausal Korean women. It is unknown whether this association varies with age. Methods Data on height loss over...
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| Format: | Article |
| Language: | English |
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Korean Endocrine Society
2023-12-01
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| Series: | Endocrinology and Metabolism |
| Subjects: | |
| Online Access: | http://www.e-enm.org/upload/pdf/enm-2023-1734.pdf |
| _version_ | 1827393521073520640 |
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| author | Chaewon Lee Hye-Sun Park Yumie Rhee Namki Hong |
| author_facet | Chaewon Lee Hye-Sun Park Yumie Rhee Namki Hong |
| author_sort | Chaewon Lee |
| collection | DOAJ |
| description | Background Height loss is a simple clinical measure associated with increased fracture risk. However, limited data exists on the association between height loss and fracture risk in postmenopausal Korean women. It is unknown whether this association varies with age. Methods Data on height loss over a 6-year period were collected from a community-based longitudinal follow-up cohort (Ansung cohort of the Korean Genome and Epidemiology Study). Incident fractures were defined based on self-reported fractures after excluding those due to severe trauma or toes/fingers. The association between incident fractures and height loss was investigated using a Cox proportional hazards model. Results During a median follow-up of 10 years after the second visit, 259/1,806 participants (median age, 64 years) experienced incident fractures. Overall, a 1 standard deviation (SD) decrease in height (1.6 cm/median 5.8 years) was associated with 9% increased risk of fracture (hazard ratio [HR], 1.09; P=0.037), which lost statistical significance after adjustment for covariates. When stratified into age groups (50–59, 60–69, 70 years or older), a 1 SD decrease in height remained a robust predictor of fracture in the 50 to 59 years age group after adjusting for covariates (adjusted hazard ratio [aHR], 1.52; P=0.003), whereas height loss was not an independent predictor of fracture in the 60 to 69 (aHR, 1.06; P=0.333) or the 70 years or older age groups (aHR, 1.05; P=0.700; P for interaction <0.05, for all). Conclusion Height loss during the previous 6 years was associated with an increased 10-year fracture risk in postmenopausal women in their 50s. |
| first_indexed | 2024-03-08T17:51:19Z |
| format | Article |
| id | doaj.art-9e6878bb1fb548dfae46ee99a4f105b3 |
| institution | Directory Open Access Journal |
| issn | 2093-596X 2093-5978 |
| language | English |
| last_indexed | 2024-03-08T17:51:19Z |
| publishDate | 2023-12-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj.art-9e6878bb1fb548dfae46ee99a4f105b32024-01-02T08:10:38ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782023-12-0138666967810.3803/EnM.2023.17342416Age-Dependent Association of Height Loss with Incident Fracture Risk in Postmenopausal Korean WomenChaewon Lee0Hye-Sun Park1Yumie Rhee2Namki Hong3 Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, Korea Department of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of Medicine, Seoul, KoreaBackground Height loss is a simple clinical measure associated with increased fracture risk. However, limited data exists on the association between height loss and fracture risk in postmenopausal Korean women. It is unknown whether this association varies with age. Methods Data on height loss over a 6-year period were collected from a community-based longitudinal follow-up cohort (Ansung cohort of the Korean Genome and Epidemiology Study). Incident fractures were defined based on self-reported fractures after excluding those due to severe trauma or toes/fingers. The association between incident fractures and height loss was investigated using a Cox proportional hazards model. Results During a median follow-up of 10 years after the second visit, 259/1,806 participants (median age, 64 years) experienced incident fractures. Overall, a 1 standard deviation (SD) decrease in height (1.6 cm/median 5.8 years) was associated with 9% increased risk of fracture (hazard ratio [HR], 1.09; P=0.037), which lost statistical significance after adjustment for covariates. When stratified into age groups (50–59, 60–69, 70 years or older), a 1 SD decrease in height remained a robust predictor of fracture in the 50 to 59 years age group after adjusting for covariates (adjusted hazard ratio [aHR], 1.52; P=0.003), whereas height loss was not an independent predictor of fracture in the 60 to 69 (aHR, 1.06; P=0.333) or the 70 years or older age groups (aHR, 1.05; P=0.700; P for interaction <0.05, for all). Conclusion Height loss during the previous 6 years was associated with an increased 10-year fracture risk in postmenopausal women in their 50s.http://www.e-enm.org/upload/pdf/enm-2023-1734.pdfbody heightfractures, bonecohort studies |
| spellingShingle | Chaewon Lee Hye-Sun Park Yumie Rhee Namki Hong Age-Dependent Association of Height Loss with Incident Fracture Risk in Postmenopausal Korean Women Endocrinology and Metabolism body height fractures, bone cohort studies |
| title | Age-Dependent Association of Height Loss with Incident Fracture Risk in Postmenopausal Korean Women |
| title_full | Age-Dependent Association of Height Loss with Incident Fracture Risk in Postmenopausal Korean Women |
| title_fullStr | Age-Dependent Association of Height Loss with Incident Fracture Risk in Postmenopausal Korean Women |
| title_full_unstemmed | Age-Dependent Association of Height Loss with Incident Fracture Risk in Postmenopausal Korean Women |
| title_short | Age-Dependent Association of Height Loss with Incident Fracture Risk in Postmenopausal Korean Women |
| title_sort | age dependent association of height loss with incident fracture risk in postmenopausal korean women |
| topic | body height fractures, bone cohort studies |
| url | http://www.e-enm.org/upload/pdf/enm-2023-1734.pdf |
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