Intra-Brain and Plasma Levels of L-Serine Are Associated with Cognitive Status in Patients with Chronic Kidney Disease
Introduction: The number of patients with chronic kidney disease (CKD) is increasing worldwide. Cognitive impairment is one of the comorbidities of CKD. With the increased number of aged population, novel biomarkers of impaired cognitive function are required. Intra-body profile of amino acid (AA) i...
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| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2023-01-01
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| Series: | Kidney Diseases |
| Subjects: | |
| Online Access: | https://www.karger.com/Article/FullText/527798 |
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| author | Yasunori Iwata Yusuke Nakade Masashi Kinoshita Hemragul Sabit Riho Nakajima Kengo Furuichi Masashi Mita Maiko Nakane Norihiko Sakai Shinji Kitajima Tadashi Toyama Taro Miyagawa Akinori Hara Miho Shimizu Kouichi Sato Megumi Oshima Shiori Nakagawa Yuta Yamamura Hisayuki Ogura Yoshitaka Koshino Mitsutoshi Nakada Takashi Wada |
| author_facet | Yasunori Iwata Yusuke Nakade Masashi Kinoshita Hemragul Sabit Riho Nakajima Kengo Furuichi Masashi Mita Maiko Nakane Norihiko Sakai Shinji Kitajima Tadashi Toyama Taro Miyagawa Akinori Hara Miho Shimizu Kouichi Sato Megumi Oshima Shiori Nakagawa Yuta Yamamura Hisayuki Ogura Yoshitaka Koshino Mitsutoshi Nakada Takashi Wada |
| author_sort | Yasunori Iwata |
| collection | DOAJ |
| description | Introduction: The number of patients with chronic kidney disease (CKD) is increasing worldwide. Cognitive impairment is one of the comorbidities of CKD. With the increased number of aged population, novel biomarkers of impaired cognitive function are required. Intra-body profile of amino acid (AA) is reportedly altered in patients with CKD. Although some AAs act as neurotransmitters in the brain, it is not clear whether altered AA profile are associated with cognitive function in patients with CKD. Therefore, intra-brain and plasma levels of AAs are evaluated with respect to cognitive function in patients with CKD. Methods: Plasma levels of AAs were compared between 14 patients with CKD, including 8 patients with diabetic kidney disease, and 12 healthy controls to identify the alteration of specific AAs in CKD. Then, these AAs were evaluated in the brains of 42 patients with brain tumor using non-tumor lesion of the resected brain. Cognitive function is analyzed with respect to intra-brain levels of AAs and kidney function. Moreover, plasma AAs were analyzed in 32 hemodialyzed patients with/without dementia. Results: In patients with CKD, plasma levels of asparagine (Asn), serine (Ser), alanine (Ala), and proline (Pro) were increased as compared to patients without CKD. Among these AAs, L-Ser, L-Ala, and D-Ser show higher levels than the other AAs in the brain. Intra-brain levels of L-Ser was correlated with cognitive function and kidney function. The number of D-amino acid oxidase or serine racemase-positive cells was not correlated with kidney function. Moreover, the plasma levels of L-Ser are also decreased in patients with declined cognitive function who are treated with chronic hemodialysis. Conclusion: The decreased levels of L-Ser are associated with impaired cognitive function in CKD patients. Especially, plasma L-Ser levels may have a potential for novel biomarker of impaired cognitive function in patients with hemodialysis. |
| first_indexed | 2024-04-10T16:20:28Z |
| format | Article |
| id | doaj.art-9e68d08040e842428bdee1940eab2695 |
| institution | Directory Open Access Journal |
| issn | 2296-9381 2296-9357 |
| language | English |
| last_indexed | 2024-04-10T16:20:28Z |
| publishDate | 2023-01-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Kidney Diseases |
| spelling | doaj.art-9e68d08040e842428bdee1940eab26952023-02-09T15:14:03ZengKarger PublishersKidney Diseases2296-93812296-93572023-01-0111210.1159/000527798527798Intra-Brain and Plasma Levels of L-Serine Are Associated with Cognitive Status in Patients with Chronic Kidney DiseaseYasunori Iwata0Yusuke Nakade1Masashi Kinoshita2Hemragul Sabit3Riho Nakajima4Kengo Furuichi5Masashi Mita6Maiko Nakane7Norihiko Sakai8Shinji Kitajima9Tadashi Toyama10Taro Miyagawa11https://orcid.org/0000-0003-0186-7362Akinori Hara12Miho Shimizu13Kouichi Sato14Megumi Oshima15Shiori Nakagawa16https://orcid.org/0000-0001-6774-7959Yuta Yamamura17Hisayuki Ogura18Yoshitaka Koshino19Mitsutoshi Nakada20https://orcid.org/0000-0001-9419-6101Takashi Wada21Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, JapanDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, JapanDepartment of Neurosurgery, Kanazawa University, Kanazawa, JapanDepartment of Neurosurgery, Kanazawa University, Kanazawa, JapanDepartment of Occupational Therapy, Kanazawa University, Kanazawa, JapanDivision of Nephrology, Kanazawa Medical University School of Medicine, Kanazawa, JapanKAGAMI Inc., Ibaraki, JapanKAGAMI Inc., Ibaraki, JapanDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, JapanDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, JapanDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, JapanDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, JapanDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, JapanDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, JapanDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, JapanDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, JapanDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, JapanDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, JapanDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, JapanDepartment of Internal Medicine, Mizuho Hospital, Kahoku, JapanDepartment of Neurosurgery, Kanazawa University, Kanazawa, JapanDepartment of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, JapanIntroduction: The number of patients with chronic kidney disease (CKD) is increasing worldwide. Cognitive impairment is one of the comorbidities of CKD. With the increased number of aged population, novel biomarkers of impaired cognitive function are required. Intra-body profile of amino acid (AA) is reportedly altered in patients with CKD. Although some AAs act as neurotransmitters in the brain, it is not clear whether altered AA profile are associated with cognitive function in patients with CKD. Therefore, intra-brain and plasma levels of AAs are evaluated with respect to cognitive function in patients with CKD. Methods: Plasma levels of AAs were compared between 14 patients with CKD, including 8 patients with diabetic kidney disease, and 12 healthy controls to identify the alteration of specific AAs in CKD. Then, these AAs were evaluated in the brains of 42 patients with brain tumor using non-tumor lesion of the resected brain. Cognitive function is analyzed with respect to intra-brain levels of AAs and kidney function. Moreover, plasma AAs were analyzed in 32 hemodialyzed patients with/without dementia. Results: In patients with CKD, plasma levels of asparagine (Asn), serine (Ser), alanine (Ala), and proline (Pro) were increased as compared to patients without CKD. Among these AAs, L-Ser, L-Ala, and D-Ser show higher levels than the other AAs in the brain. Intra-brain levels of L-Ser was correlated with cognitive function and kidney function. The number of D-amino acid oxidase or serine racemase-positive cells was not correlated with kidney function. Moreover, the plasma levels of L-Ser are also decreased in patients with declined cognitive function who are treated with chronic hemodialysis. Conclusion: The decreased levels of L-Ser are associated with impaired cognitive function in CKD patients. Especially, plasma L-Ser levels may have a potential for novel biomarker of impaired cognitive function in patients with hemodialysis.https://www.karger.com/Article/FullText/527798l-serinechronic kidney diseasecognitive impairment |
| spellingShingle | Yasunori Iwata Yusuke Nakade Masashi Kinoshita Hemragul Sabit Riho Nakajima Kengo Furuichi Masashi Mita Maiko Nakane Norihiko Sakai Shinji Kitajima Tadashi Toyama Taro Miyagawa Akinori Hara Miho Shimizu Kouichi Sato Megumi Oshima Shiori Nakagawa Yuta Yamamura Hisayuki Ogura Yoshitaka Koshino Mitsutoshi Nakada Takashi Wada Intra-Brain and Plasma Levels of L-Serine Are Associated with Cognitive Status in Patients with Chronic Kidney Disease Kidney Diseases l-serine chronic kidney disease cognitive impairment |
| title | Intra-Brain and Plasma Levels of L-Serine Are Associated with Cognitive Status in Patients with Chronic Kidney Disease |
| title_full | Intra-Brain and Plasma Levels of L-Serine Are Associated with Cognitive Status in Patients with Chronic Kidney Disease |
| title_fullStr | Intra-Brain and Plasma Levels of L-Serine Are Associated with Cognitive Status in Patients with Chronic Kidney Disease |
| title_full_unstemmed | Intra-Brain and Plasma Levels of L-Serine Are Associated with Cognitive Status in Patients with Chronic Kidney Disease |
| title_short | Intra-Brain and Plasma Levels of L-Serine Are Associated with Cognitive Status in Patients with Chronic Kidney Disease |
| title_sort | intra brain and plasma levels of l serine are associated with cognitive status in patients with chronic kidney disease |
| topic | l-serine chronic kidney disease cognitive impairment |
| url | https://www.karger.com/Article/FullText/527798 |
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