Is Male Sex A Prognostic Factor in Papillary Thyroid Cancer?
Identifying risk factors is crucial for predicting papillary thyroid cancer (PTC) with severe course, which causes a clinical problem. The purpose of this study was to assess whether male sex can be such a predictive factor and to verify whether including it as a predictive factor of high initial ri...
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MDPI AG
2021-05-01
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Series: | Journal of Clinical Medicine |
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Online Access: | https://www.mdpi.com/2077-0383/10/11/2438 |
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author | Aleksandra Gajowiec Anna Chromik Kinga Furga Alicja Skuza Danuta Gąsior-Perczak Agnieszka Walczyk Iwona Pałyga Tomasz Trybek Estera Mikina Monika Szymonek Klaudia Gadawska-Juszczyk Artur Kuchareczko Agnieszka Suligowska Jarosław Jaskulski Paweł Orłowski Magdalena Chrapek Stanisław Góźdź Aldona Kowalska |
author_facet | Aleksandra Gajowiec Anna Chromik Kinga Furga Alicja Skuza Danuta Gąsior-Perczak Agnieszka Walczyk Iwona Pałyga Tomasz Trybek Estera Mikina Monika Szymonek Klaudia Gadawska-Juszczyk Artur Kuchareczko Agnieszka Suligowska Jarosław Jaskulski Paweł Orłowski Magdalena Chrapek Stanisław Góźdź Aldona Kowalska |
author_sort | Aleksandra Gajowiec |
collection | DOAJ |
description | Identifying risk factors is crucial for predicting papillary thyroid cancer (PTC) with severe course, which causes a clinical problem. The purpose of this study was to assess whether male sex can be such a predictive factor and to verify whether including it as a predictive factor of high initial risk of recurrence/persistence would help to enhance the value of the American Thyroid Association initial risk stratification system (ATA). We retrospectively analyzed 1547 PTC patients (1358 females and 189 males), treated from 1986 to 2018. The relationship between sex and clinicopathological features, response to therapy, and disease status was assessed. Men with PTC showed some adverse clinicopathological features more often than women, including angioinvasion, lymph node metastases, and tumor size > 40 mm. There were sex-related disparities with respect to response to initial therapy and final follow-up. Male sex is associated with some unfavorable clinicopathological features of PTC, which may affect response to initial therapy or final disease status. In our study, modification of the ATA system by including male sex as a risk factor does not enhance its value. Thus, further studies are needed to assess whether males require treatment modalities or oncological follow-up protocols that are different from those of females. |
first_indexed | 2024-03-10T10:51:52Z |
format | Article |
id | doaj.art-9e698b464b24491382c0d8e5007ebbfd |
institution | Directory Open Access Journal |
issn | 2077-0383 |
language | English |
last_indexed | 2024-03-10T10:51:52Z |
publishDate | 2021-05-01 |
publisher | MDPI AG |
record_format | Article |
series | Journal of Clinical Medicine |
spelling | doaj.art-9e698b464b24491382c0d8e5007ebbfd2023-11-21T22:10:49ZengMDPI AGJournal of Clinical Medicine2077-03832021-05-011011243810.3390/jcm10112438Is Male Sex A Prognostic Factor in Papillary Thyroid Cancer?Aleksandra Gajowiec0Anna Chromik1Kinga Furga2Alicja Skuza3Danuta Gąsior-Perczak4Agnieszka Walczyk5Iwona Pałyga6Tomasz Trybek7Estera Mikina8Monika Szymonek9Klaudia Gadawska-Juszczyk10Artur Kuchareczko11Agnieszka Suligowska12Jarosław Jaskulski13Paweł Orłowski14Magdalena Chrapek15Stanisław Góźdź16Aldona Kowalska17ESKULAP Student Scientific Organization, Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, PolandESKULAP Student Scientific Organization, Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, PolandESKULAP Student Scientific Organization, Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, PolandESKULAP Student Scientific Organization, Collegium Medicum, Jan Kochanowski University, 25-317 Kielce, PolandCollegium Medicum, Jan Kochanowski University, 25-317 Kielce, PolandCollegium Medicum, Jan Kochanowski University, 25-317 Kielce, PolandCollegium Medicum, Jan Kochanowski University, 25-317 Kielce, PolandEndocrinology Clinic, Holycross Cancer Centre, S. Artwińskiego Str. 3, 25-734 Kielce, PolandEndocrinology Clinic, Holycross Cancer Centre, S. Artwińskiego Str. 3, 25-734 Kielce, PolandEndocrinology Clinic, Holycross Cancer Centre, S. Artwińskiego Str. 3, 25-734 Kielce, PolandEndocrinology Clinic, Holycross Cancer Centre, S. Artwińskiego Str. 3, 25-734 Kielce, PolandEndocrinology Clinic, Holycross Cancer Centre, S. Artwińskiego Str. 3, 25-734 Kielce, PolandEndocrinology Clinic, Holycross Cancer Centre, S. Artwińskiego Str. 3, 25-734 Kielce, PolandCollegium Medicum, Jan Kochanowski University, 25-317 Kielce, PolandCollegium Medicum, Jan Kochanowski University, 25-317 Kielce, PolandFaculty of Natural Sciences, Jan Kochanowski University, 25-406 Kielce, PolandCollegium Medicum, Jan Kochanowski University, 25-317 Kielce, PolandCollegium Medicum, Jan Kochanowski University, 25-317 Kielce, PolandIdentifying risk factors is crucial for predicting papillary thyroid cancer (PTC) with severe course, which causes a clinical problem. The purpose of this study was to assess whether male sex can be such a predictive factor and to verify whether including it as a predictive factor of high initial risk of recurrence/persistence would help to enhance the value of the American Thyroid Association initial risk stratification system (ATA). We retrospectively analyzed 1547 PTC patients (1358 females and 189 males), treated from 1986 to 2018. The relationship between sex and clinicopathological features, response to therapy, and disease status was assessed. Men with PTC showed some adverse clinicopathological features more often than women, including angioinvasion, lymph node metastases, and tumor size > 40 mm. There were sex-related disparities with respect to response to initial therapy and final follow-up. Male sex is associated with some unfavorable clinicopathological features of PTC, which may affect response to initial therapy or final disease status. In our study, modification of the ATA system by including male sex as a risk factor does not enhance its value. Thus, further studies are needed to assess whether males require treatment modalities or oncological follow-up protocols that are different from those of females.https://www.mdpi.com/2077-0383/10/11/2438papillary thyroid cancermale sexresponse to therapyrisk stratification |
spellingShingle | Aleksandra Gajowiec Anna Chromik Kinga Furga Alicja Skuza Danuta Gąsior-Perczak Agnieszka Walczyk Iwona Pałyga Tomasz Trybek Estera Mikina Monika Szymonek Klaudia Gadawska-Juszczyk Artur Kuchareczko Agnieszka Suligowska Jarosław Jaskulski Paweł Orłowski Magdalena Chrapek Stanisław Góźdź Aldona Kowalska Is Male Sex A Prognostic Factor in Papillary Thyroid Cancer? Journal of Clinical Medicine papillary thyroid cancer male sex response to therapy risk stratification |
title | Is Male Sex A Prognostic Factor in Papillary Thyroid Cancer? |
title_full | Is Male Sex A Prognostic Factor in Papillary Thyroid Cancer? |
title_fullStr | Is Male Sex A Prognostic Factor in Papillary Thyroid Cancer? |
title_full_unstemmed | Is Male Sex A Prognostic Factor in Papillary Thyroid Cancer? |
title_short | Is Male Sex A Prognostic Factor in Papillary Thyroid Cancer? |
title_sort | is male sex a prognostic factor in papillary thyroid cancer |
topic | papillary thyroid cancer male sex response to therapy risk stratification |
url | https://www.mdpi.com/2077-0383/10/11/2438 |
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