A meta-analysis of postoperative outcomes of patients with and without chronic hepatitis C undergoing primary total hip or knee arthroplasty
Purpose: This investigation provides a rigorous systematic review of the postoperative outcomes of patients with and without chronic hepatitis C who underwent total hip arthroplasty (THA) and total knee arthroplasty (TKA). Methods: We queried PubMed, Embase, Cochrane Database of Systematic Reviews...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2023-05-01
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| Series: | EFORT Open Reviews |
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| Online Access: | https://eor.bioscientifica.com/view/journals/eor/8/4/EOR-22-0117.xml |
| _version_ | 1797835621510676480 |
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| author | Mark D Kohn Charles J Wolock Isaac J Poulson Navin D Fernando |
| author_facet | Mark D Kohn Charles J Wolock Isaac J Poulson Navin D Fernando |
| author_sort | Mark D Kohn |
| collection | DOAJ |
| description | Purpose: This investigation provides a rigorous systematic review of the postoperative outcomes of patients with and without chronic hepatitis C who underwent total hip arthroplasty (THA) and total knee arthroplasty (TKA).
Methods: We queried PubMed, Embase, Cochrane Database of Systematic Reviews, Scopus, Web of Science and the ‘gray’ literature, including supplemental materials, conference abstracts and proceedings as well as commentary published in various peer-reviewed journals from 1992 to present to evaluate studies that compared the postoperative outcomes of patients with and without chronic hepatitis C who underwent primary THA or TKA. This investigation was registered in the PROSPERO international prospective register of systematic reviews and follows the guidelines provided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. In our literature search, we identified 14 articles that met our inclusion criteria and were included in our fixed-effects meta-analysis. The postoperative outcomes analyzed included periprosthetic joint infection (PJI), aseptic revision, non-homebound discharge and inpatient mortality.
Results: Our statistical analysis demonstrated a statistically significant increase in postoperative complications of patients with chronic hepatitis C who underwent primary THA or TKA including PJI (odds ratio (OR): 1.98, 95% CI: 1.86 – 2.10), aseptic revision (OR: 1.58, 95% CI: 1.50 – 1.67), non-homebound discharge (OR: 1.31, 95% CI: 1.28– 1.34) and inpatient mortality (OR: 9.37, 95% CI: 8.17 – 10.75).
Conclusion: This meta-analysis demonstrated a statistically significant increase in adverse postoperative complications in patients with chronic hepatitis C who underwent primary THA or TKA compared to patients without chronic hepatitis C. |
| first_indexed | 2024-04-09T14:55:35Z |
| format | Article |
| id | doaj.art-9e6aef5141844fdc9b6094b9492c8261 |
| institution | Directory Open Access Journal |
| issn | 2058-5241 |
| language | English |
| last_indexed | 2024-04-09T14:55:35Z |
| publishDate | 2023-05-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | EFORT Open Reviews |
| spelling | doaj.art-9e6aef5141844fdc9b6094b9492c82612023-05-02T06:07:14ZengBioscientificaEFORT Open Reviews2058-52412023-05-0184180188https://doi.org/10.1530/EOR-22-0117A meta-analysis of postoperative outcomes of patients with and without chronic hepatitis C undergoing primary total hip or knee arthroplastyMark D Kohn0Charles J Wolock1Isaac J Poulson2Navin D Fernando3Department of Orthopaedic Surgery and Sports Medicine, University of Washington, Seattle, Washington, USADepartment of Biostatistics, University of Washington, Seattle, Washington, USASchool of Medicine, University of Washington, Seattle, Washington, USADepartment of Orthopaedic Surgery and Sports Medicine, University of Washington, Seattle, Washington, USAPurpose: This investigation provides a rigorous systematic review of the postoperative outcomes of patients with and without chronic hepatitis C who underwent total hip arthroplasty (THA) and total knee arthroplasty (TKA). Methods: We queried PubMed, Embase, Cochrane Database of Systematic Reviews, Scopus, Web of Science and the ‘gray’ literature, including supplemental materials, conference abstracts and proceedings as well as commentary published in various peer-reviewed journals from 1992 to present to evaluate studies that compared the postoperative outcomes of patients with and without chronic hepatitis C who underwent primary THA or TKA. This investigation was registered in the PROSPERO international prospective register of systematic reviews and follows the guidelines provided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. In our literature search, we identified 14 articles that met our inclusion criteria and were included in our fixed-effects meta-analysis. The postoperative outcomes analyzed included periprosthetic joint infection (PJI), aseptic revision, non-homebound discharge and inpatient mortality. Results: Our statistical analysis demonstrated a statistically significant increase in postoperative complications of patients with chronic hepatitis C who underwent primary THA or TKA including PJI (odds ratio (OR): 1.98, 95% CI: 1.86 – 2.10), aseptic revision (OR: 1.58, 95% CI: 1.50 – 1.67), non-homebound discharge (OR: 1.31, 95% CI: 1.28– 1.34) and inpatient mortality (OR: 9.37, 95% CI: 8.17 – 10.75). Conclusion: This meta-analysis demonstrated a statistically significant increase in adverse postoperative complications in patients with chronic hepatitis C who underwent primary THA or TKA compared to patients without chronic hepatitis C. https://eor.bioscientifica.com/view/journals/eor/8/4/EOR-22-0117.xmltotal joint arthroplastytotal knee arthroplastytotal hip arthroplastychronic hepatitis cpostoperative outcomes |
| spellingShingle | Mark D Kohn Charles J Wolock Isaac J Poulson Navin D Fernando A meta-analysis of postoperative outcomes of patients with and without chronic hepatitis C undergoing primary total hip or knee arthroplasty EFORT Open Reviews total joint arthroplasty total knee arthroplasty total hip arthroplasty chronic hepatitis c postoperative outcomes |
| title | A meta-analysis of postoperative outcomes of patients with and without chronic hepatitis C undergoing primary total hip or knee arthroplasty |
| title_full | A meta-analysis of postoperative outcomes of patients with and without chronic hepatitis C undergoing primary total hip or knee arthroplasty |
| title_fullStr | A meta-analysis of postoperative outcomes of patients with and without chronic hepatitis C undergoing primary total hip or knee arthroplasty |
| title_full_unstemmed | A meta-analysis of postoperative outcomes of patients with and without chronic hepatitis C undergoing primary total hip or knee arthroplasty |
| title_short | A meta-analysis of postoperative outcomes of patients with and without chronic hepatitis C undergoing primary total hip or knee arthroplasty |
| title_sort | meta analysis of postoperative outcomes of patients with and without chronic hepatitis c undergoing primary total hip or knee arthroplasty |
| topic | total joint arthroplasty total knee arthroplasty total hip arthroplasty chronic hepatitis c postoperative outcomes |
| url | https://eor.bioscientifica.com/view/journals/eor/8/4/EOR-22-0117.xml |
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