Focusing on the Emerging Role of Kainate Receptors in the Dorsal Cochlear Nucleus (DCN) and Cerebellum
Mammals have a dorsal cochlear nucleus (DCN), which is thought to be a cerebellum-like structure with similar features in terms of structure and microcircuitry to the cerebellum. Both the DCN and cerebellum perform their functions depending on synaptic and neuronal networks mediated by various gluta...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/2/1718 |
| _version_ | 1797441028681105408 |
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| author | Qin-Wei Wu Zheng-Quan Tang |
| author_facet | Qin-Wei Wu Zheng-Quan Tang |
| author_sort | Qin-Wei Wu |
| collection | DOAJ |
| description | Mammals have a dorsal cochlear nucleus (DCN), which is thought to be a cerebellum-like structure with similar features in terms of structure and microcircuitry to the cerebellum. Both the DCN and cerebellum perform their functions depending on synaptic and neuronal networks mediated by various glutamate receptors. Kainate receptors (KARs) are one class of the glutamate receptor family and are strongly expressed in the hippocampus, the cerebellum, and cerebellum-like structures. The cellular distribution and the potential role of KARs in the hippocampus have been extensively investigated. However, the cellular distribution and the potential role of KARs in cerebellum-like structures, including the DCN and cerebellum, are poorly understood. In this review, we summarize the similarity between the DCN and cerebellum at the levels of structure, circuitry, and cell type as well as the investigations referring to the expression patterns of KARs in the DCN and cerebellum according to previous studies. Recent studies on the role of KARs have shown that KARs mediate a bidirectional modulatory effect at parallel fiber (PF)–Purkinje cell (PC) synapses in the cerebellum, implying insights into their roles in cerebellum-like structures, including the DCN, that remain to be explored in the coming years. |
| first_indexed | 2024-03-09T12:18:08Z |
| format | Article |
| id | doaj.art-9e6b8c9ec1e24007b71d8e35f60a21a1 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T12:18:08Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
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| series | International Journal of Molecular Sciences |
| spelling | doaj.art-9e6b8c9ec1e24007b71d8e35f60a21a12023-11-30T22:44:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01242171810.3390/ijms24021718Focusing on the Emerging Role of Kainate Receptors in the Dorsal Cochlear Nucleus (DCN) and CerebellumQin-Wei Wu0Zheng-Quan Tang1School of Life Sciences, Anhui University, Hefei 230601, ChinaSchool of Life Sciences, Anhui University, Hefei 230601, ChinaMammals have a dorsal cochlear nucleus (DCN), which is thought to be a cerebellum-like structure with similar features in terms of structure and microcircuitry to the cerebellum. Both the DCN and cerebellum perform their functions depending on synaptic and neuronal networks mediated by various glutamate receptors. Kainate receptors (KARs) are one class of the glutamate receptor family and are strongly expressed in the hippocampus, the cerebellum, and cerebellum-like structures. The cellular distribution and the potential role of KARs in the hippocampus have been extensively investigated. However, the cellular distribution and the potential role of KARs in cerebellum-like structures, including the DCN and cerebellum, are poorly understood. In this review, we summarize the similarity between the DCN and cerebellum at the levels of structure, circuitry, and cell type as well as the investigations referring to the expression patterns of KARs in the DCN and cerebellum according to previous studies. Recent studies on the role of KARs have shown that KARs mediate a bidirectional modulatory effect at parallel fiber (PF)–Purkinje cell (PC) synapses in the cerebellum, implying insights into their roles in cerebellum-like structures, including the DCN, that remain to be explored in the coming years.https://www.mdpi.com/1422-0067/24/2/1718KARDCNkainate receptorsdorsal cochlear nucleuscerebellumcerebellum-like structure |
| spellingShingle | Qin-Wei Wu Zheng-Quan Tang Focusing on the Emerging Role of Kainate Receptors in the Dorsal Cochlear Nucleus (DCN) and Cerebellum International Journal of Molecular Sciences KAR DCN kainate receptors dorsal cochlear nucleus cerebellum cerebellum-like structure |
| title | Focusing on the Emerging Role of Kainate Receptors in the Dorsal Cochlear Nucleus (DCN) and Cerebellum |
| title_full | Focusing on the Emerging Role of Kainate Receptors in the Dorsal Cochlear Nucleus (DCN) and Cerebellum |
| title_fullStr | Focusing on the Emerging Role of Kainate Receptors in the Dorsal Cochlear Nucleus (DCN) and Cerebellum |
| title_full_unstemmed | Focusing on the Emerging Role of Kainate Receptors in the Dorsal Cochlear Nucleus (DCN) and Cerebellum |
| title_short | Focusing on the Emerging Role of Kainate Receptors in the Dorsal Cochlear Nucleus (DCN) and Cerebellum |
| title_sort | focusing on the emerging role of kainate receptors in the dorsal cochlear nucleus dcn and cerebellum |
| topic | KAR DCN kainate receptors dorsal cochlear nucleus cerebellum cerebellum-like structure |
| url | https://www.mdpi.com/1422-0067/24/2/1718 |
| work_keys_str_mv | AT qinweiwu focusingontheemergingroleofkainatereceptorsinthedorsalcochlearnucleusdcnandcerebellum AT zhengquantang focusingontheemergingroleofkainatereceptorsinthedorsalcochlearnucleusdcnandcerebellum |