Formulation and in vitro Evaluations of Paracetamol Orally Disintegrating Tablets
Orally disintegrating tablets are a solid dosage form compromising medicinal substances which disintegrate rapidly, generally within a matter of seconds, when placed on the tongue. In this study, paracetamol orally disintegrating tablets was formulated and evaluated. Direct compression was used to p...
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| Format: | Article |
| Language: | English |
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LPPT Universitas Gadjah Mada
2023-03-01
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| Series: | Journal of Food and Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://jurnal.ugm.ac.id/v3/JFPS/article/view/6162 |
| _version_ | 1797448414054580224 |
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| author | Azmiera Azimuddin Mohamad Farhan Roslan Riyanto Teguh Widodo |
| author_facet | Azmiera Azimuddin Mohamad Farhan Roslan Riyanto Teguh Widodo |
| author_sort | Azmiera Azimuddin |
| collection | DOAJ |
| description | Orally disintegrating tablets are a solid dosage form compromising medicinal substances which disintegrate rapidly, generally within a matter of seconds, when placed on the tongue. In this study, paracetamol orally disintegrating tablets was formulated and evaluated. Direct compression was used to prepare 350 mg tablets of five formulations (F1- F5) by using a single punch manual tableting machine. Pre-formulation studies were performed on the powder mixture of each formulation to obtain information regarding their flow properties. The tablets from each formulation were also evaluated for weight uniformity, drug content uniformity, thickness, hardness, friability, disintegration and dissolution. The disintegration tests carried out revealed that tablets from F2 showed the shortest disintegration time of 32.67 ± 3.14 seconds followed by tablets from F5, F3, F4 and F1. However, the dissolution results illustrated that tablets from F5 have the best dissolution profile, releasing 84.70 ± 5.31% of drugs within 4 minutes. Hence the most optimized formulation of a paracetamol orally disintegrating tablet in this study. |
| first_indexed | 2024-03-09T14:10:05Z |
| format | Article |
| id | doaj.art-9e6c146f4b2d45709328856baa714b3b |
| institution | Directory Open Access Journal |
| issn | 2089-7200 2339-0948 |
| language | English |
| last_indexed | 2024-03-09T14:10:05Z |
| publishDate | 2023-03-01 |
| publisher | LPPT Universitas Gadjah Mada |
| record_format | Article |
| series | Journal of Food and Pharmaceutical Sciences |
| spelling | doaj.art-9e6c146f4b2d45709328856baa714b3b2023-11-29T13:54:22ZengLPPT Universitas Gadjah MadaJournal of Food and Pharmaceutical Sciences2089-72002339-09482023-03-0178078710.22146/jfps.61626162Formulation and in vitro Evaluations of Paracetamol Orally Disintegrating TabletsAzmiera Azimuddin0Mohamad Farhan Roslan1Riyanto Teguh Widodo2Department of Pharmaceutical Technology. Faculty of Pharmacy, University Malaya, Kuala Lumpur, MalaysiaDepartment of Pharmaceutical Technology. Faculty of Pharmacy, University Malaya, Kuala Lumpur, MalaysiaDepartment of Pharmaceutical Technology. Faculty of Pharmacy, University Malaya, Kuala Lumpur, MalaysiaOrally disintegrating tablets are a solid dosage form compromising medicinal substances which disintegrate rapidly, generally within a matter of seconds, when placed on the tongue. In this study, paracetamol orally disintegrating tablets was formulated and evaluated. Direct compression was used to prepare 350 mg tablets of five formulations (F1- F5) by using a single punch manual tableting machine. Pre-formulation studies were performed on the powder mixture of each formulation to obtain information regarding their flow properties. The tablets from each formulation were also evaluated for weight uniformity, drug content uniformity, thickness, hardness, friability, disintegration and dissolution. The disintegration tests carried out revealed that tablets from F2 showed the shortest disintegration time of 32.67 ± 3.14 seconds followed by tablets from F5, F3, F4 and F1. However, the dissolution results illustrated that tablets from F5 have the best dissolution profile, releasing 84.70 ± 5.31% of drugs within 4 minutes. Hence the most optimized formulation of a paracetamol orally disintegrating tablet in this study.https://jurnal.ugm.ac.id/v3/JFPS/article/view/6162paracetamolorallly disintegrating tabletsdirect compression |
| spellingShingle | Azmiera Azimuddin Mohamad Farhan Roslan Riyanto Teguh Widodo Formulation and in vitro Evaluations of Paracetamol Orally Disintegrating Tablets Journal of Food and Pharmaceutical Sciences paracetamol orallly disintegrating tablets direct compression |
| title | Formulation and in vitro Evaluations of Paracetamol Orally Disintegrating Tablets |
| title_full | Formulation and in vitro Evaluations of Paracetamol Orally Disintegrating Tablets |
| title_fullStr | Formulation and in vitro Evaluations of Paracetamol Orally Disintegrating Tablets |
| title_full_unstemmed | Formulation and in vitro Evaluations of Paracetamol Orally Disintegrating Tablets |
| title_short | Formulation and in vitro Evaluations of Paracetamol Orally Disintegrating Tablets |
| title_sort | formulation and in vitro evaluations of paracetamol orally disintegrating tablets |
| topic | paracetamol orallly disintegrating tablets direct compression |
| url | https://jurnal.ugm.ac.id/v3/JFPS/article/view/6162 |
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