Association of Angiotensin Converting Enzyme (ACE) Gene Polymorphism and Diabetic Nephropathy
Angiotensin I-converting Enzyme (ACE) gene polymorphism; genotype DD or D allele may be involved with an increased susceptibility to type 2 diabetes and diabetic nephropathy (DN). We examined the frequency of ACE gene polymorphism in 170 patients (85 type 2 diabetes with nephropathy and 85 without i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2006-09-01
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| Series: | Iranian Journal of Public Health |
| Subjects: | |
| Online Access: | https://ijph.tums.ac.ir/index.php/ijph/article/view/2158 |
| _version_ | 1818569856136511488 |
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| author | T Golmohamadi A Nikzamir M Nakhjavani M Zahrai A Amirzargar R Saffari |
| author_facet | T Golmohamadi A Nikzamir M Nakhjavani M Zahrai A Amirzargar R Saffari |
| author_sort | T Golmohamadi |
| collection | DOAJ |
| description | Angiotensin I-converting Enzyme (ACE) gene polymorphism; genotype DD or D allele may be involved with an increased susceptibility to type 2 diabetes and diabetic nephropathy (DN). We examined the frequency of ACE gene polymorphism in 170 patients (85 type 2 diabetes with nephropathy and 85 without it) in Tehran, Iran. DNA was extracted from the white blood cells and the I/D polymorphism of the ACE gene was detected by PCR. The frequency of DD, ID and II genotypes in type 2 diabetic patients were 20%, 61.2% and 18.8%, and in patients with nephropathy 30.6%, 55.3%, 14.1%, respectively. The DD genotype of the DN group was higher than that of the type 2 diabetes patients (30.6% vs 20%, P=0.157, RR=1.3) and the control group (30.6% vs 14.3%, P=0.006, RR=2.9). The frequency of D allele in nephropathic patients was 58.2% as compared to the type 2 diabetic patients without nephropathy (50.5%) P=0.19, RR=1.16. The D allele frequency in the DN group was found slightly higher than of the type 2 diabetes (X2=0.684, OR=0.709, 95%CI: 0.313-1.606, P=0.408) which indicated the D allele was not associated with DN. It is suggested that DD genotype and D allele are not associated with diabetic nephropathy. |
| first_indexed | 2024-12-14T06:53:10Z |
| format | Article |
| id | doaj.art-9e6d42bdf207442c8411a2a45a2de685 |
| institution | Directory Open Access Journal |
| issn | 2251-6085 2251-6093 |
| language | English |
| last_indexed | 2024-12-14T06:53:10Z |
| publishDate | 2006-09-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-9e6d42bdf207442c8411a2a45a2de6852022-12-21T23:12:49ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852251-60932006-09-01353Association of Angiotensin Converting Enzyme (ACE) Gene Polymorphism and Diabetic Nephropathy T Golmohamadi0 A Nikzamir1 M Nakhjavani2 M Zahrai3 A Amirzargar4 R Saffari5 Angiotensin I-converting Enzyme (ACE) gene polymorphism; genotype DD or D allele may be involved with an increased susceptibility to type 2 diabetes and diabetic nephropathy (DN). We examined the frequency of ACE gene polymorphism in 170 patients (85 type 2 diabetes with nephropathy and 85 without it) in Tehran, Iran. DNA was extracted from the white blood cells and the I/D polymorphism of the ACE gene was detected by PCR. The frequency of DD, ID and II genotypes in type 2 diabetic patients were 20%, 61.2% and 18.8%, and in patients with nephropathy 30.6%, 55.3%, 14.1%, respectively. The DD genotype of the DN group was higher than that of the type 2 diabetes patients (30.6% vs 20%, P=0.157, RR=1.3) and the control group (30.6% vs 14.3%, P=0.006, RR=2.9). The frequency of D allele in nephropathic patients was 58.2% as compared to the type 2 diabetic patients without nephropathy (50.5%) P=0.19, RR=1.16. The D allele frequency in the DN group was found slightly higher than of the type 2 diabetes (X2=0.684, OR=0.709, 95%CI: 0.313-1.606, P=0.408) which indicated the D allele was not associated with DN. It is suggested that DD genotype and D allele are not associated with diabetic nephropathy.https://ijph.tums.ac.ir/index.php/ijph/article/view/2158Angiotensin converting enzymeGenetic polymorphismInsertion/deletion |
| spellingShingle | T Golmohamadi A Nikzamir M Nakhjavani M Zahrai A Amirzargar R Saffari Association of Angiotensin Converting Enzyme (ACE) Gene Polymorphism and Diabetic Nephropathy Iranian Journal of Public Health Angiotensin converting enzyme Genetic polymorphism Insertion/deletion |
| title | Association of Angiotensin Converting Enzyme (ACE) Gene Polymorphism and Diabetic Nephropathy |
| title_full | Association of Angiotensin Converting Enzyme (ACE) Gene Polymorphism and Diabetic Nephropathy |
| title_fullStr | Association of Angiotensin Converting Enzyme (ACE) Gene Polymorphism and Diabetic Nephropathy |
| title_full_unstemmed | Association of Angiotensin Converting Enzyme (ACE) Gene Polymorphism and Diabetic Nephropathy |
| title_short | Association of Angiotensin Converting Enzyme (ACE) Gene Polymorphism and Diabetic Nephropathy |
| title_sort | association of angiotensin converting enzyme ace gene polymorphism and diabetic nephropathy |
| topic | Angiotensin converting enzyme Genetic polymorphism Insertion/deletion |
| url | https://ijph.tums.ac.ir/index.php/ijph/article/view/2158 |
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