Corneal thinning following bevacizumab intrastromal injection for the treatment of idiopathic lipid keratopathy
Purpose: To describe the occurrence of corneal thinning in a patient following intrastromal injection of bevacizumab to treat lipid keratopathy. Observations: A 36-year-old female presented with decreased vision in her right eye with central posterior corneal haze and underwent a treatment regimen i...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993622003644 |
| _version_ | 1828355865663504384 |
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| author | Kristie J. Sun Albert S. Jun Kelley Bohm Daniel Daroszewski Samir Jabbour |
| author_facet | Kristie J. Sun Albert S. Jun Kelley Bohm Daniel Daroszewski Samir Jabbour |
| author_sort | Kristie J. Sun |
| collection | DOAJ |
| description | Purpose: To describe the occurrence of corneal thinning in a patient following intrastromal injection of bevacizumab to treat lipid keratopathy. Observations: A 36-year-old female presented with decreased vision in her right eye with central posterior corneal haze and underwent a treatment regimen including artificial tears, cyclosporine 0.05% drops, prednisolone 1% and oral Valacyclovir 1g with no improvement. Neovascularization was noted at 18 months follow up and treated with intrastromal bevacizumab injections at 24 months. The feeder vessel was attenuated at 3- and 6-months post-injection, but tomography indicated sustained thinning and flattening of the cornea at the injection site contributing to the development of irregular astigmatism. Conclusions and Importance: Corneal thinning is an uncommon potential side effect of intrastromal bevacizumab injection that may affect postoperative visual acuity. |
| first_indexed | 2024-04-14T02:50:25Z |
| format | Article |
| id | doaj.art-9e6d438aa8294b348ac00c63ae7e54c0 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-04-14T02:50:25Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-9e6d438aa8294b348ac00c63ae7e54c02022-12-22T02:16:19ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362022-09-0127101618Corneal thinning following bevacizumab intrastromal injection for the treatment of idiopathic lipid keratopathyKristie J. Sun0Albert S. Jun1Kelley Bohm2Daniel Daroszewski3Samir Jabbour4Case Western Reserve University School of Medicine, 9501 Euclid Ave, Cleveland, OH, USA, 44106; The Johns Hopkins Wilmer Eye Institute, 1800 Orleans St, Baltimore, MD, USA, 21287The Johns Hopkins Wilmer Eye Institute, 1800 Orleans St, Baltimore, MD, USA, 21287The Johns Hopkins Wilmer Eye Institute, 1800 Orleans St, Baltimore, MD, USA, 21287The Johns Hopkins Wilmer Eye Institute, 1800 Orleans St, Baltimore, MD, USA, 21287The Johns Hopkins Wilmer Eye Institute, 1800 Orleans St, Baltimore, MD, USA, 21287; Department of Ophthalmology, Centre hospitalier de l’Université de Montréal, 1051 Sanguinet st, Montreal, QC, Canada, H2X 3E4; Corresponding author. Department of Ophthalmology, Centre hospitalier de l’Université de Montréal, 1051 Sanguinet st, Montreal, QC, Canada, H2X 3E4.Purpose: To describe the occurrence of corneal thinning in a patient following intrastromal injection of bevacizumab to treat lipid keratopathy. Observations: A 36-year-old female presented with decreased vision in her right eye with central posterior corneal haze and underwent a treatment regimen including artificial tears, cyclosporine 0.05% drops, prednisolone 1% and oral Valacyclovir 1g with no improvement. Neovascularization was noted at 18 months follow up and treated with intrastromal bevacizumab injections at 24 months. The feeder vessel was attenuated at 3- and 6-months post-injection, but tomography indicated sustained thinning and flattening of the cornea at the injection site contributing to the development of irregular astigmatism. Conclusions and Importance: Corneal thinning is an uncommon potential side effect of intrastromal bevacizumab injection that may affect postoperative visual acuity.http://www.sciencedirect.com/science/article/pii/S2451993622003644Corneal thinningBevacizumab injection |
| spellingShingle | Kristie J. Sun Albert S. Jun Kelley Bohm Daniel Daroszewski Samir Jabbour Corneal thinning following bevacizumab intrastromal injection for the treatment of idiopathic lipid keratopathy American Journal of Ophthalmology Case Reports Corneal thinning Bevacizumab injection |
| title | Corneal thinning following bevacizumab intrastromal injection for the treatment of idiopathic lipid keratopathy |
| title_full | Corneal thinning following bevacizumab intrastromal injection for the treatment of idiopathic lipid keratopathy |
| title_fullStr | Corneal thinning following bevacizumab intrastromal injection for the treatment of idiopathic lipid keratopathy |
| title_full_unstemmed | Corneal thinning following bevacizumab intrastromal injection for the treatment of idiopathic lipid keratopathy |
| title_short | Corneal thinning following bevacizumab intrastromal injection for the treatment of idiopathic lipid keratopathy |
| title_sort | corneal thinning following bevacizumab intrastromal injection for the treatment of idiopathic lipid keratopathy |
| topic | Corneal thinning Bevacizumab injection |
| url | http://www.sciencedirect.com/science/article/pii/S2451993622003644 |
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