Inhibition of <i>Pseudomonas aeruginosa</i> Biofilm Formation with Surface Modified Polymeric Nanoparticles
The gram-negative bacterial pathogen <i>Pseudomonas aeruginosa</i> represents a prominent clinical concern. Due to the observed high levels of antibiotic resistance, copious biofilm formation, and wide array of virulence factors produced by these bacteria, new treatment technologies are...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-04-01
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| Series: | Pathogens |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-0817/8/2/55 |
| _version_ | 1798024683465998336 |
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| author | Tyler R. Flockton Logan Schnorbus Agustin Araujo Jill Adams Maryjane Hammel Lark J. Perez |
| author_facet | Tyler R. Flockton Logan Schnorbus Agustin Araujo Jill Adams Maryjane Hammel Lark J. Perez |
| author_sort | Tyler R. Flockton |
| collection | DOAJ |
| description | The gram-negative bacterial pathogen <i>Pseudomonas aeruginosa</i> represents a prominent clinical concern. Due to the observed high levels of antibiotic resistance, copious biofilm formation, and wide array of virulence factors produced by these bacteria, new treatment technologies are required. Here, we present the development of a series of <i>P. aeruginosa</i> LecA-targeted polymeric nanoparticles and demonstrate the anti-adhesion and biofilm inhibitory properties of these constructs. |
| first_indexed | 2024-04-11T18:06:37Z |
| format | Article |
| id | doaj.art-9e74b3bf1dd84d99929c17c4b9e9e8e7 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-04-11T18:06:37Z |
| publishDate | 2019-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-9e74b3bf1dd84d99929c17c4b9e9e8e72022-12-22T04:10:19ZengMDPI AGPathogens2076-08172019-04-01825510.3390/pathogens8020055pathogens8020055Inhibition of <i>Pseudomonas aeruginosa</i> Biofilm Formation with Surface Modified Polymeric NanoparticlesTyler R. Flockton0Logan Schnorbus1Agustin Araujo2Jill Adams3Maryjane Hammel4Lark J. Perez5Department of Chemistry and Biochemistry, Rowan University, 201 Mullica Hill Road, Glassboro, NJ 08028, USADepartment of Chemistry and Biochemistry, Rowan University, 201 Mullica Hill Road, Glassboro, NJ 08028, USADepartment of Chemistry and Biochemistry, Rowan University, 201 Mullica Hill Road, Glassboro, NJ 08028, USADepartment of Chemistry and Biochemistry, Rowan University, 201 Mullica Hill Road, Glassboro, NJ 08028, USADepartment of Chemistry and Biochemistry, Rowan University, 201 Mullica Hill Road, Glassboro, NJ 08028, USADepartment of Chemistry and Biochemistry, Rowan University, 201 Mullica Hill Road, Glassboro, NJ 08028, USAThe gram-negative bacterial pathogen <i>Pseudomonas aeruginosa</i> represents a prominent clinical concern. Due to the observed high levels of antibiotic resistance, copious biofilm formation, and wide array of virulence factors produced by these bacteria, new treatment technologies are required. Here, we present the development of a series of <i>P. aeruginosa</i> LecA-targeted polymeric nanoparticles and demonstrate the anti-adhesion and biofilm inhibitory properties of these constructs.https://www.mdpi.com/2076-0817/8/2/55biofilminhibitionantivirulencelectin<i>Pseudomonas aeruginosa</i>nanoparticle |
| spellingShingle | Tyler R. Flockton Logan Schnorbus Agustin Araujo Jill Adams Maryjane Hammel Lark J. Perez Inhibition of <i>Pseudomonas aeruginosa</i> Biofilm Formation with Surface Modified Polymeric Nanoparticles Pathogens biofilm inhibition antivirulence lectin <i>Pseudomonas aeruginosa</i> nanoparticle |
| title | Inhibition of <i>Pseudomonas aeruginosa</i> Biofilm Formation with Surface Modified Polymeric Nanoparticles |
| title_full | Inhibition of <i>Pseudomonas aeruginosa</i> Biofilm Formation with Surface Modified Polymeric Nanoparticles |
| title_fullStr | Inhibition of <i>Pseudomonas aeruginosa</i> Biofilm Formation with Surface Modified Polymeric Nanoparticles |
| title_full_unstemmed | Inhibition of <i>Pseudomonas aeruginosa</i> Biofilm Formation with Surface Modified Polymeric Nanoparticles |
| title_short | Inhibition of <i>Pseudomonas aeruginosa</i> Biofilm Formation with Surface Modified Polymeric Nanoparticles |
| title_sort | inhibition of i pseudomonas aeruginosa i biofilm formation with surface modified polymeric nanoparticles |
| topic | biofilm inhibition antivirulence lectin <i>Pseudomonas aeruginosa</i> nanoparticle |
| url | https://www.mdpi.com/2076-0817/8/2/55 |
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