Pharmacologic inhibition of NLRP3 reduces the levels of α-synuclein and protects dopaminergic neurons in a model of Parkinson’s disease

Pharmacologic inhibition of NLRP3 reduces the levels of α-synuclein and protects dopaminergic neurons in a model of Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is characterized by a progressive degeneration of dopaminergic neurons, which leads to irreversible loss of peripheral motor functions. Death of dopaminergic neurons induces an inflammatory response in microglial cells, which further exacerbates neuronal...

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Bibliographic Details
Main Authors: Jesus Amo-Aparicio, Jonathan Daly, Jesper Falkesgaard Højen, Charles A. Dinarello
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Neuroinflammation
Subjects:
Inflammasome
NLRP3
α-synuclein
OLT1177
Parkinson’s disease
Online Access:https://doi.org/10.1186/s12974-023-02830-w

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