A Retrospective Observational Study of Risk Factors for Denosumab-Related Osteonecrosis of the Jaw in Patients with Bone Metastases from Solid Cancers
This single-center retrospective observational study aimed to identify risk factors for developing denosumab-related osteonecrosis of the jaw (DRONJ) in stage IV solid cancer patients with bone metastases. In total, 123 consecutive patients who had received 120 mg of denosumab every 4 weeks at least...
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| Format: | Article |
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MDPI AG
2020-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/5/1209 |
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| author | Satoe Okuma Yuhei Matsuda Yoshiki Nariai Masaaki Karino Ritsuro Suzuki Takahiro Kanno |
| author_facet | Satoe Okuma Yuhei Matsuda Yoshiki Nariai Masaaki Karino Ritsuro Suzuki Takahiro Kanno |
| author_sort | Satoe Okuma |
| collection | DOAJ |
| description | This single-center retrospective observational study aimed to identify risk factors for developing denosumab-related osteonecrosis of the jaw (DRONJ) in stage IV solid cancer patients with bone metastases. In total, 123 consecutive patients who had received 120 mg of denosumab every 4 weeks at least twice between July 2014 and October 2018 were included. We surveyed their demographics, medical history, blood test, underlying disease, and intraoral findings. Fourteen patients (11.4%) developed DRONJ within a mean denosumab administration period of 4 months (range: 2–52 months). Univariate analyses showed a statistically significant correlation between DRONJ and hormone therapy, chemotherapy/molecular target drug, apical periodontitis, periodontal disease, sex and body mass index. Multivariate analysis showed a statistically significant correlation between DRONJ and hormone therapy (odds ratio [OR], 22.07; 95% confidence interval [CI], 2.86–170.24), chemotherapy and/or molecular targeted therapy (OR, 18.61; 95% CI, 2.54–136.27), and apical periodontitis (OR, 22.75; 95% CI, 3.20–161.73). These findings imply that collaborative oral examinations by oral specialists may reduce the risk of development of DRONJ in patients treated with denosumab for bone metastases from solid cancers. |
| first_indexed | 2024-03-10T19:53:45Z |
| format | Article |
| id | doaj.art-9e77c7a6d4d3498eaa7238ab9acb710e |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T19:53:45Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9e77c7a6d4d3498eaa7238ab9acb710e2023-11-20T00:09:06ZengMDPI AGCancers2072-66942020-05-01125120910.3390/cancers12051209A Retrospective Observational Study of Risk Factors for Denosumab-Related Osteonecrosis of the Jaw in Patients with Bone Metastases from Solid CancersSatoe Okuma0Yuhei Matsuda1Yoshiki Nariai2Masaaki Karino3Ritsuro Suzuki4Takahiro Kanno5Department of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Shimane 693-8501, JapanDepartment of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Shimane 693-8501, JapanDepartment of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Shimane 693-8501, JapanDepartment of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Shimane 693-8501, JapanDepartment of Oncology/Hematology and Innovative Cancer Center, Shimane University Hospital, Shimane 693-8501, JapanDepartment of Oral and Maxillofacial Surgery, Shimane University Faculty of Medicine, Shimane 693-8501, JapanThis single-center retrospective observational study aimed to identify risk factors for developing denosumab-related osteonecrosis of the jaw (DRONJ) in stage IV solid cancer patients with bone metastases. In total, 123 consecutive patients who had received 120 mg of denosumab every 4 weeks at least twice between July 2014 and October 2018 were included. We surveyed their demographics, medical history, blood test, underlying disease, and intraoral findings. Fourteen patients (11.4%) developed DRONJ within a mean denosumab administration period of 4 months (range: 2–52 months). Univariate analyses showed a statistically significant correlation between DRONJ and hormone therapy, chemotherapy/molecular target drug, apical periodontitis, periodontal disease, sex and body mass index. Multivariate analysis showed a statistically significant correlation between DRONJ and hormone therapy (odds ratio [OR], 22.07; 95% confidence interval [CI], 2.86–170.24), chemotherapy and/or molecular targeted therapy (OR, 18.61; 95% CI, 2.54–136.27), and apical periodontitis (OR, 22.75; 95% CI, 3.20–161.73). These findings imply that collaborative oral examinations by oral specialists may reduce the risk of development of DRONJ in patients treated with denosumab for bone metastases from solid cancers.https://www.mdpi.com/2072-6694/12/5/1209denosumab-related osteonecrosis of the jawbone metastasisdenosumabretrospective cohort study |
| spellingShingle | Satoe Okuma Yuhei Matsuda Yoshiki Nariai Masaaki Karino Ritsuro Suzuki Takahiro Kanno A Retrospective Observational Study of Risk Factors for Denosumab-Related Osteonecrosis of the Jaw in Patients with Bone Metastases from Solid Cancers Cancers denosumab-related osteonecrosis of the jaw bone metastasis denosumab retrospective cohort study |
| title | A Retrospective Observational Study of Risk Factors for Denosumab-Related Osteonecrosis of the Jaw in Patients with Bone Metastases from Solid Cancers |
| title_full | A Retrospective Observational Study of Risk Factors for Denosumab-Related Osteonecrosis of the Jaw in Patients with Bone Metastases from Solid Cancers |
| title_fullStr | A Retrospective Observational Study of Risk Factors for Denosumab-Related Osteonecrosis of the Jaw in Patients with Bone Metastases from Solid Cancers |
| title_full_unstemmed | A Retrospective Observational Study of Risk Factors for Denosumab-Related Osteonecrosis of the Jaw in Patients with Bone Metastases from Solid Cancers |
| title_short | A Retrospective Observational Study of Risk Factors for Denosumab-Related Osteonecrosis of the Jaw in Patients with Bone Metastases from Solid Cancers |
| title_sort | retrospective observational study of risk factors for denosumab related osteonecrosis of the jaw in patients with bone metastases from solid cancers |
| topic | denosumab-related osteonecrosis of the jaw bone metastasis denosumab retrospective cohort study |
| url | https://www.mdpi.com/2072-6694/12/5/1209 |
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