Governing HPV-related carcinoma using vaccines: Bottlenecks and breakthroughs
Human papillomavirus (HPV) contributes to sexually transmitted infection, which is primarily associated with pre-cancerous and cancerous lesions in both men and women and is among the neglected cancerous infections in the world. At global level, two-, four-, and nine-valent pure L1 protein encompass...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.977933/full |
| _version_ | 1828176319866732544 |
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| author | Rahul Bhattacharjee Lamha Kumar Archna Dhasmana Tamoghni Mitra Abhijit Dey Sumira Malik Bonglee Kim Rohit Gundamaraju |
| author_facet | Rahul Bhattacharjee Lamha Kumar Archna Dhasmana Tamoghni Mitra Abhijit Dey Sumira Malik Bonglee Kim Rohit Gundamaraju |
| author_sort | Rahul Bhattacharjee |
| collection | DOAJ |
| description | Human papillomavirus (HPV) contributes to sexually transmitted infection, which is primarily associated with pre-cancerous and cancerous lesions in both men and women and is among the neglected cancerous infections in the world. At global level, two-, four-, and nine-valent pure L1 protein encompassed vaccines in targeting high-risk HPV strains using recombinant DNA technology are available. Therapeutic vaccines are produced by early and late oncoproteins that impart superior cell immunity to preventive vaccines that are under investigation. In the current review, we have not only discussed the clinical significance and importance of both preventive and therapeutic vaccines but also highlighted their dosage and mode of administration. This review is novel in its way and will pave the way for researchers to address the challenges posed by HPV-based vaccines at the present time. |
| first_indexed | 2024-04-12T04:42:22Z |
| format | Article |
| id | doaj.art-9e7853f6f7e640c7a89125c6c5b91b1e |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T04:42:22Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9e7853f6f7e640c7a89125c6c5b91b1e2022-12-22T03:47:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.977933977933Governing HPV-related carcinoma using vaccines: Bottlenecks and breakthroughsRahul Bhattacharjee0Lamha Kumar1Archna Dhasmana2Tamoghni Mitra3Abhijit Dey4Sumira Malik5Bonglee Kim6Rohit Gundamaraju7Department of Cell and Developmental Biology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, IsraelSchool of Biology, Indian Institute of Science Education and Research, Thiruvananthapuram, IndiaHimalayan School of Biosciences, Swami Rama Himalayan University, Dehradun, IndiaKIIT School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT-DU), Bhubaneswar, Odisha, IndiaDepartment of Life Sciences, Presidency University, Kolkata, West Bengal, IndiaAmity Institute of Biotechnology, Amity University Jharkhand, Ranchi, Jharkhand, IndiaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, South KoreaER Stress and Mucosal Immunology Lab, School of Health Sciences, University of Tasmania, Launceston, TAS, AustraliaHuman papillomavirus (HPV) contributes to sexually transmitted infection, which is primarily associated with pre-cancerous and cancerous lesions in both men and women and is among the neglected cancerous infections in the world. At global level, two-, four-, and nine-valent pure L1 protein encompassed vaccines in targeting high-risk HPV strains using recombinant DNA technology are available. Therapeutic vaccines are produced by early and late oncoproteins that impart superior cell immunity to preventive vaccines that are under investigation. In the current review, we have not only discussed the clinical significance and importance of both preventive and therapeutic vaccines but also highlighted their dosage and mode of administration. This review is novel in its way and will pave the way for researchers to address the challenges posed by HPV-based vaccines at the present time.https://www.frontiersin.org/articles/10.3389/fonc.2022.977933/fullvaccineshuman papillomaviruscervical cancerviral cancerstherapeutic vaccines |
| spellingShingle | Rahul Bhattacharjee Lamha Kumar Archna Dhasmana Tamoghni Mitra Abhijit Dey Sumira Malik Bonglee Kim Rohit Gundamaraju Governing HPV-related carcinoma using vaccines: Bottlenecks and breakthroughs Frontiers in Oncology vaccines human papillomavirus cervical cancer viral cancers therapeutic vaccines |
| title | Governing HPV-related carcinoma using vaccines: Bottlenecks and breakthroughs |
| title_full | Governing HPV-related carcinoma using vaccines: Bottlenecks and breakthroughs |
| title_fullStr | Governing HPV-related carcinoma using vaccines: Bottlenecks and breakthroughs |
| title_full_unstemmed | Governing HPV-related carcinoma using vaccines: Bottlenecks and breakthroughs |
| title_short | Governing HPV-related carcinoma using vaccines: Bottlenecks and breakthroughs |
| title_sort | governing hpv related carcinoma using vaccines bottlenecks and breakthroughs |
| topic | vaccines human papillomavirus cervical cancer viral cancers therapeutic vaccines |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.977933/full |
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