From defense to offense: Modulating toll-like receptors to combat arbovirus infections
ABSTRACTArboviruses are a significant threat to global public health, with outbreaks occurring worldwide. Toll-like receptors (TLRs) play a crucial role in the innate immune response against these viruses by recognizing pathogen-associated molecular patterns and initiating an inflammatory response....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2024.2306675 |
| _version_ | 1827375553652457472 |
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| author | Rafidah Lani Ilya Maisarah Thariq Nuramira Syazreen Suhaimi Pouya Hassandarvish Sazaly Abu Bakar |
| author_facet | Rafidah Lani Ilya Maisarah Thariq Nuramira Syazreen Suhaimi Pouya Hassandarvish Sazaly Abu Bakar |
| author_sort | Rafidah Lani |
| collection | DOAJ |
| description | ABSTRACTArboviruses are a significant threat to global public health, with outbreaks occurring worldwide. Toll-like receptors (TLRs) play a crucial role in the innate immune response against these viruses by recognizing pathogen-associated molecular patterns and initiating an inflammatory response. Significantly, TLRs commonly implicated in the immune response against viral infections include TLR2, TLR4, TLR6, TLR3, TLR7, and TLR8; limiting or allowing them to replicate and spread within the host. Modulating TLRs has emerged as a promising approach to combat arbovirus infections. This review summarizes recent advances in TLR modulation as a therapeutic target in arbovirus infections. Studies have shown that the activation of TLRs can enhance the immune response against arbovirus infections, leading to increased viral clearance and protection against disease. Conversely, inhibition of TLRs can reduce the excessive inflammation and tissue damage associated with arbovirus infection. Modulating TLRs represents a potential therapeutic strategy to combat arbovirus infections. |
| first_indexed | 2024-03-08T11:52:35Z |
| format | Article |
| id | doaj.art-9e791ceff46b4d12b1bb2f34f8cd4159 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-08T11:52:35Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-9e791ceff46b4d12b1bb2f34f8cd41592024-01-24T05:59:51ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2024-12-0120110.1080/21645515.2024.2306675From defense to offense: Modulating toll-like receptors to combat arbovirus infectionsRafidah Lani0Ilya Maisarah Thariq1Nuramira Syazreen Suhaimi2Pouya Hassandarvish3Sazaly Abu Bakar4Department of Medical Microbiology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre, Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre, Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre, Universiti Malaya, Kuala Lumpur, MalaysiaTropical Infectious Diseases Research and Education Centre, Universiti Malaya, Kuala Lumpur, MalaysiaABSTRACTArboviruses are a significant threat to global public health, with outbreaks occurring worldwide. Toll-like receptors (TLRs) play a crucial role in the innate immune response against these viruses by recognizing pathogen-associated molecular patterns and initiating an inflammatory response. Significantly, TLRs commonly implicated in the immune response against viral infections include TLR2, TLR4, TLR6, TLR3, TLR7, and TLR8; limiting or allowing them to replicate and spread within the host. Modulating TLRs has emerged as a promising approach to combat arbovirus infections. This review summarizes recent advances in TLR modulation as a therapeutic target in arbovirus infections. Studies have shown that the activation of TLRs can enhance the immune response against arbovirus infections, leading to increased viral clearance and protection against disease. Conversely, inhibition of TLRs can reduce the excessive inflammation and tissue damage associated with arbovirus infection. Modulating TLRs represents a potential therapeutic strategy to combat arbovirus infections.https://www.tandfonline.com/doi/10.1080/21645515.2024.2306675Infectious diseasearbovirusestoll-like receptorsmodulationagonistantagonist |
| spellingShingle | Rafidah Lani Ilya Maisarah Thariq Nuramira Syazreen Suhaimi Pouya Hassandarvish Sazaly Abu Bakar From defense to offense: Modulating toll-like receptors to combat arbovirus infections Human Vaccines & Immunotherapeutics Infectious disease arboviruses toll-like receptors modulation agonist antagonist |
| title | From defense to offense: Modulating toll-like receptors to combat arbovirus infections |
| title_full | From defense to offense: Modulating toll-like receptors to combat arbovirus infections |
| title_fullStr | From defense to offense: Modulating toll-like receptors to combat arbovirus infections |
| title_full_unstemmed | From defense to offense: Modulating toll-like receptors to combat arbovirus infections |
| title_short | From defense to offense: Modulating toll-like receptors to combat arbovirus infections |
| title_sort | from defense to offense modulating toll like receptors to combat arbovirus infections |
| topic | Infectious disease arboviruses toll-like receptors modulation agonist antagonist |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2024.2306675 |
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