Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans.

Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans.

The let-7 microRNA (miRNA) regulates cellular differentiation across many animal species. Loss of let-7 activity causes abnormal development in Caenorhabditis elegans and unchecked cellular proliferation in human cells, which contributes to tumorigenesis. These defects are due to improper expression...

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Bibliographic Details
Main Authors: Shaun E Hunter, Emily F Finnegan, Dimitrios G Zisoulis, Michael T Lovci, Katya V Melnik-Martinez, Gene W Yeo, Amy E Pasquinelli
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3597506?pdf=render

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