Detection of olfactory dysfunction using olfactory event related potentials in young patients with multiple sclerosis.
Several studies reported olfactory dysfunction in patients with multiple sclerosis. The estimate of the incidence of olfactory deficits in multiple sclerosis is uncertain; this may arise from different testing methods that may be influenced by patients' response bias and clinical, demographic a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4105616?pdf=render |
| _version_ | 1828261066630496256 |
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| author | Fabrizia Caminiti Simona De Salvo Maria Cristina De Cola Margherita Russo Placido Bramanti Silvia Marino Rosella Ciurleo |
| author_facet | Fabrizia Caminiti Simona De Salvo Maria Cristina De Cola Margherita Russo Placido Bramanti Silvia Marino Rosella Ciurleo |
| author_sort | Fabrizia Caminiti |
| collection | DOAJ |
| description | Several studies reported olfactory dysfunction in patients with multiple sclerosis. The estimate of the incidence of olfactory deficits in multiple sclerosis is uncertain; this may arise from different testing methods that may be influenced by patients' response bias and clinical, demographic and cognitive features.To evaluate objectively the olfactory function using Olfactory Event Related Potentials.We tested the olfactory function of 30 patients with relapsing remitting multiple sclerosis (mean age of 36.03±6.96 years) and of 30 age, sex and smoking-habit matched healthy controls by using olfactory potentials. A selective and controlled stimulation of the olfactory system to elicit the olfactory event related potentials was achieved by a computer-controlled olfactometer linked directly with electroencephalograph. Relationships between olfactory potential results and patients' clinical characteristics, such as gender, disability status score, disease-modifying therapy, and disease duration, were evaluated.Seven of 30 patients did not show olfactory event related potentials. Sixteen of remaining 23 patients had a mean value of amplitude significantly lower than control group (p<0.01). The presence/absence of olfactory event related potentials was associated with dichotomous expanded disability status scale (p = 0.0433), as well as inversely correlated with the disease duration (r = -0.3641, p = 0.0479).Unbiased olfactory dysfunction of different severity found in multiple sclerosis patients suggests an organic impairment which could be related to neuroinflammatory and/or neurodegenerative processes of olfactory networks, supporting the recent findings on neurophysiopathology of disease. |
| first_indexed | 2024-04-13T03:32:51Z |
| format | Article |
| id | doaj.art-9e7bba5aca53420996b9d21a26f3f2c4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T03:32:51Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9e7bba5aca53420996b9d21a26f3f2c42022-12-22T03:04:25ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10315110.1371/journal.pone.0103151Detection of olfactory dysfunction using olfactory event related potentials in young patients with multiple sclerosis.Fabrizia CaminitiSimona De SalvoMaria Cristina De ColaMargherita RussoPlacido BramantiSilvia MarinoRosella CiurleoSeveral studies reported olfactory dysfunction in patients with multiple sclerosis. The estimate of the incidence of olfactory deficits in multiple sclerosis is uncertain; this may arise from different testing methods that may be influenced by patients' response bias and clinical, demographic and cognitive features.To evaluate objectively the olfactory function using Olfactory Event Related Potentials.We tested the olfactory function of 30 patients with relapsing remitting multiple sclerosis (mean age of 36.03±6.96 years) and of 30 age, sex and smoking-habit matched healthy controls by using olfactory potentials. A selective and controlled stimulation of the olfactory system to elicit the olfactory event related potentials was achieved by a computer-controlled olfactometer linked directly with electroencephalograph. Relationships between olfactory potential results and patients' clinical characteristics, such as gender, disability status score, disease-modifying therapy, and disease duration, were evaluated.Seven of 30 patients did not show olfactory event related potentials. Sixteen of remaining 23 patients had a mean value of amplitude significantly lower than control group (p<0.01). The presence/absence of olfactory event related potentials was associated with dichotomous expanded disability status scale (p = 0.0433), as well as inversely correlated with the disease duration (r = -0.3641, p = 0.0479).Unbiased olfactory dysfunction of different severity found in multiple sclerosis patients suggests an organic impairment which could be related to neuroinflammatory and/or neurodegenerative processes of olfactory networks, supporting the recent findings on neurophysiopathology of disease.http://europepmc.org/articles/PMC4105616?pdf=render |
| spellingShingle | Fabrizia Caminiti Simona De Salvo Maria Cristina De Cola Margherita Russo Placido Bramanti Silvia Marino Rosella Ciurleo Detection of olfactory dysfunction using olfactory event related potentials in young patients with multiple sclerosis. PLoS ONE |
| title | Detection of olfactory dysfunction using olfactory event related potentials in young patients with multiple sclerosis. |
| title_full | Detection of olfactory dysfunction using olfactory event related potentials in young patients with multiple sclerosis. |
| title_fullStr | Detection of olfactory dysfunction using olfactory event related potentials in young patients with multiple sclerosis. |
| title_full_unstemmed | Detection of olfactory dysfunction using olfactory event related potentials in young patients with multiple sclerosis. |
| title_short | Detection of olfactory dysfunction using olfactory event related potentials in young patients with multiple sclerosis. |
| title_sort | detection of olfactory dysfunction using olfactory event related potentials in young patients with multiple sclerosis |
| url | http://europepmc.org/articles/PMC4105616?pdf=render |
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