Immune responses elicited in tertiary lymphoid tissues display distinctive features.
During chronic inflammation, immune effectors progressively organize themselves into a functional tertiary lymphoid tissue (TLT) within the targeted organ. TLT has been observed in a wide range of chronic inflammatory conditions but its pathophysiological significance remains unknown. We used the ra...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2010-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2894881?pdf=render |
| _version_ | 1818267388444934144 |
|---|---|
| author | Olivier Thaunat Stéphanie Graff-Dubois Sophie Brouard Chantal Gautreau Aditi Varthaman Nicole Fabien Anne-Christine Field Liliane Louedec Jianping Dai Etienne Joly Emmanuel Morelon Jean-Paul Soulillou Jean-Baptiste Michel Antonino Nicoletti |
| author_facet | Olivier Thaunat Stéphanie Graff-Dubois Sophie Brouard Chantal Gautreau Aditi Varthaman Nicole Fabien Anne-Christine Field Liliane Louedec Jianping Dai Etienne Joly Emmanuel Morelon Jean-Paul Soulillou Jean-Baptiste Michel Antonino Nicoletti |
| author_sort | Olivier Thaunat |
| collection | DOAJ |
| description | During chronic inflammation, immune effectors progressively organize themselves into a functional tertiary lymphoid tissue (TLT) within the targeted organ. TLT has been observed in a wide range of chronic inflammatory conditions but its pathophysiological significance remains unknown. We used the rat aortic interposition model in which a TLT has been evidenced in the adventitia of chronically rejected allografts one month after transplantation. The immune responses elicited in adventitial TLT and those taking place in spleen and draining lymph nodes (LN) were compared in terms of antibody production, T cell activation and repertoire perturbations. The anti-MHC humoral response was more intense and more diverse in TLT. This difference was associated with an increased percentage of activated CD4+ T cells and a symmetric reduction of regulatory T cell subsets. Moreover, TCR repertoire perturbations in TLT were not only increased and different from the common pattern observed in spleen and LN but also "stochastic," since each recipient displayed a specific pattern. We propose that the abnormal activation of CD4+ T cells promotes the development of an exaggerated pathogenic immune humoral response in TLT. Preliminary findings suggest that this phenomenon i) is due to a defective immune regulation in this non-professional inflammatory-induced lymphoid tissue, and ii) also occurs in human chronically rejected grafts. |
| first_indexed | 2024-12-12T20:21:48Z |
| format | Article |
| id | doaj.art-9e7c24ec857147d58a1191253aadee4c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-12T20:21:48Z |
| publishDate | 2010-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9e7c24ec857147d58a1191253aadee4c2022-12-22T00:13:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-01-0156e1139810.1371/journal.pone.0011398Immune responses elicited in tertiary lymphoid tissues display distinctive features.Olivier ThaunatStéphanie Graff-DuboisSophie BrouardChantal GautreauAditi VarthamanNicole FabienAnne-Christine FieldLiliane LouedecJianping DaiEtienne JolyEmmanuel MorelonJean-Paul SoulillouJean-Baptiste MichelAntonino NicolettiDuring chronic inflammation, immune effectors progressively organize themselves into a functional tertiary lymphoid tissue (TLT) within the targeted organ. TLT has been observed in a wide range of chronic inflammatory conditions but its pathophysiological significance remains unknown. We used the rat aortic interposition model in which a TLT has been evidenced in the adventitia of chronically rejected allografts one month after transplantation. The immune responses elicited in adventitial TLT and those taking place in spleen and draining lymph nodes (LN) were compared in terms of antibody production, T cell activation and repertoire perturbations. The anti-MHC humoral response was more intense and more diverse in TLT. This difference was associated with an increased percentage of activated CD4+ T cells and a symmetric reduction of regulatory T cell subsets. Moreover, TCR repertoire perturbations in TLT were not only increased and different from the common pattern observed in spleen and LN but also "stochastic," since each recipient displayed a specific pattern. We propose that the abnormal activation of CD4+ T cells promotes the development of an exaggerated pathogenic immune humoral response in TLT. Preliminary findings suggest that this phenomenon i) is due to a defective immune regulation in this non-professional inflammatory-induced lymphoid tissue, and ii) also occurs in human chronically rejected grafts.http://europepmc.org/articles/PMC2894881?pdf=render |
| spellingShingle | Olivier Thaunat Stéphanie Graff-Dubois Sophie Brouard Chantal Gautreau Aditi Varthaman Nicole Fabien Anne-Christine Field Liliane Louedec Jianping Dai Etienne Joly Emmanuel Morelon Jean-Paul Soulillou Jean-Baptiste Michel Antonino Nicoletti Immune responses elicited in tertiary lymphoid tissues display distinctive features. PLoS ONE |
| title | Immune responses elicited in tertiary lymphoid tissues display distinctive features. |
| title_full | Immune responses elicited in tertiary lymphoid tissues display distinctive features. |
| title_fullStr | Immune responses elicited in tertiary lymphoid tissues display distinctive features. |
| title_full_unstemmed | Immune responses elicited in tertiary lymphoid tissues display distinctive features. |
| title_short | Immune responses elicited in tertiary lymphoid tissues display distinctive features. |
| title_sort | immune responses elicited in tertiary lymphoid tissues display distinctive features |
| url | http://europepmc.org/articles/PMC2894881?pdf=render |
| work_keys_str_mv | AT olivierthaunat immuneresponseselicitedintertiarylymphoidtissuesdisplaydistinctivefeatures AT stephaniegraffdubois immuneresponseselicitedintertiarylymphoidtissuesdisplaydistinctivefeatures AT sophiebrouard immuneresponseselicitedintertiarylymphoidtissuesdisplaydistinctivefeatures AT chantalgautreau immuneresponseselicitedintertiarylymphoidtissuesdisplaydistinctivefeatures AT aditivarthaman immuneresponseselicitedintertiarylymphoidtissuesdisplaydistinctivefeatures AT nicolefabien immuneresponseselicitedintertiarylymphoidtissuesdisplaydistinctivefeatures AT annechristinefield immuneresponseselicitedintertiarylymphoidtissuesdisplaydistinctivefeatures AT lilianelouedec immuneresponseselicitedintertiarylymphoidtissuesdisplaydistinctivefeatures AT jianpingdai immuneresponseselicitedintertiarylymphoidtissuesdisplaydistinctivefeatures AT etiennejoly immuneresponseselicitedintertiarylymphoidtissuesdisplaydistinctivefeatures AT emmanuelmorelon immuneresponseselicitedintertiarylymphoidtissuesdisplaydistinctivefeatures AT jeanpaulsoulillou immuneresponseselicitedintertiarylymphoidtissuesdisplaydistinctivefeatures AT jeanbaptistemichel immuneresponseselicitedintertiarylymphoidtissuesdisplaydistinctivefeatures AT antoninonicoletti immuneresponseselicitedintertiarylymphoidtissuesdisplaydistinctivefeatures |