Angiotensin-(1-7) relieved renal injury induced by chronic intermittent hypoxia in rats by reducing inflammation, oxidative stress and fibrosis

Angiotensin-(1-7) relieved renal injury induced by chronic intermittent hypoxia in rats by reducing inflammation, oxidative stress and fibrosis

We aimed to study the renal injury and hypertension induced by chronic intermittent hypoxia (CIH) and the protective effects mediated by angiotensin 1-7 [Ang(1-7)]. We randomly assigned 32 male Sprague-Dawley rats (body weight 180-200 g) to normoxia control, CIH, Ang(1-7)-treated normoxia, and Ang(1...

Full description

Bibliographic Details
Main Authors:	W. Lu, J. Kang, K. Hu, S. Tang, X. Zhou, S. Yu, L. Xu
Format:	Article
Language:	English
Published:	Associação Brasileira de Divulgação Científica
Series:	Brazilian Journal of Medical and Biological Research
Subjects:	Ang(1-7) Renal injury Obstructive sleep apnea Inflammation Oxidative stress Fibrosis
Online Access:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000100604&lng=en&tlng=en

Similar Items

Angiotensin-(1–7) inhibits inflammation and oxidative stress to relieve lung injury induced by chronic intermittent hypoxia in rats
by: W. Lu, et al.
Published: (2016-09-01)

Sleep Apnea in Idiopathic Pulmonary Fibrosis: A Molecular Investigation in an Experimental Model of Fibrosis and Intermittent Hypoxia
by: Liasmine Haine, et al.
Published: (2021-09-01)

Attenuation of intermittent hypoxia-induced apoptosis and fibrosis in pulmonary tissues via suppression of ER stress activation
by: Zhihui Shi, et al.
Published: (2020-04-01)

Telmisartan protects chronic intermittent hypoxic mice via modulating cardiac renin-angiotensin system activity
by: Wanyu Wang, et al.
Published: (2018-07-01)

Chronic intermittent hypoxia promotes glomerular hyperfiltration and potentiates hypoxia-evoked decreases in renal perfusion and PO2
by: Kiefer W. Kious, et al.
Published: (2023-07-01)

CircRNA expression profiles and functional analysis in a mouse model of chronic intermittent hypoxia-induced renal injury: new insight into pathogenesis
by: Qingshi Chen, et al.
Published: (2023-02-01)

Losartan is more effective than angiotensin (1–7) in preventing thyroxine-induced renal injury in the rat
by: Slava Malatiali, et al.
Published: (2024-11-01)

Metoprolol Inhibits Cardiac Apoptosis and Fibrosis in a Canine Model of Chronic Obstructive Sleep Apnea
by: Wenpeng Li, et al.
Published: (2015-06-01)

Effect of Intermittent Hypoxia on Metabolic Syndrome and Insulin Resistance in the General Male Population
by: Jung-Yup Lee, et al.
Published: (2021-06-01)

The Effects of Volatile Anesthetics on Renal Sympathetic and Phrenic Nerve Activity during Acute Intermittent Hypoxia in Rats
by: Josip Krnić, et al.
Published: (2024-04-01)

Combining VEGF receptor inhibitors and angiotensin-(1–7) to target renal cell carcinoma
by: Thomas Walther, et al.
Published: (2021-07-01)

Elevated Oxidative Stress and Inflammation in Hypothalamic Paraventricular Nucleus Are Associated With Sympathetic Excitation and Hypertension in Rats Exposed to Chronic Intermittent Hypoxia
by: Tiejun Li, et al.
Published: (2018-07-01)

The role of ferroptosis in chronic intermittent hypoxia-induced lung injury
by: Jia Chen, et al.
Published: (2022-12-01)

Angiotensin-(1-7) Modulates the Warburg Effect to Alleviate Inflammation in LPS-Induced Macrophages and Septic Mice
by: Yu D, et al.
Published: (2024-01-01)

Ocular Inflammation and Oxidative Stress as a Result of Chronic Intermittent Hypoxia: A Rat Model of Sleep Apnea
by: Nina Donkor, et al.
Published: (2024-07-01)

Can the Apnea-Hypopnea Index Be a Marker of Liver Fibrosis in Patients with Obstructive Sleep Apnea?
by: Ayşe Karaoğullarından, et al.
Published: (2024-06-01)

Associations of Intermittent Hypoxia Burden with Gut Microbiota Dysbiosis in Adult Patients with Obstructive Sleep Apnea
by: Guo W, et al.
Published: (2024-09-01)

Chemical renal denervation-induced upregulation of the ACE2/Ang (1-7)/Mas axis attenuates blood pressure elevation in spontaneously hypertensive rats
by: Wenzheng Han, et al.
Published: (2020-10-01)

The efficacy of antihypertensive drugs in chronic intermittent hypoxia conditions
by: Lucilia Neves Diogo, et al.
Published: (2014-09-01)

Danggui-Buxue decoction alleviated vascular senescence in mice exposed to chronic intermittent hypoxia through activating the Nrf2/HO-1 pathway
by: Dongli Li, et al.
Published: (2023-12-01)

Chronic Intermittent Hypoxia-Induced Dysmetabolism Is Associated with Hepatic Oxidative Stress, Mitochondrial Dysfunction and Inflammation
by: Joana L. Fernandes, et al.
Published: (2023-10-01)

Breathing patterns during sleep and their relationship with FEV1 in pediatric patients with cystic fibrosis residing at high altitude
by: Elida Duenas-Meza, et al.
Published: (2024-08-01)

Nocturnal hypoxemia, cardiac remodeling, and blood concentrations of fibrosis biomarkers in patients with atrial fibrillation and obstructive sleep apnea
by: V. A. Berdysheva, et al.
Published: (2025-01-01)

Orexin-A Reverse Bone Mass Loss Induced by Chronic Intermittent Hypoxia Through OX1R-Nrf2/HIF-1α Pathway
by: Gu H, et al.
Published: (2022-07-01)

Obstructive sleep apnea and nocturnal hypoxemia in adult patients with cystic fibrosis
by: Matthias Welsner, et al.
Published: (2022-11-01)

Risk factors of obstructive sleep apnea syndrome in the developmental age
by: Irena Sionek, et al.
Published: (2024-10-01)

Zebrafish Model to Study Angiotensin II-Mediated Pathophysiology
by: Bhagyashri Joshi, et al.
Published: (2021-11-01)

Renin-angiotensin system modulators in COVID-19 patients with hypertension: friend or foe?
by: Shakhi Shylesh C.M, et al.
Published: (2022-01-01)

L-Citrulline Supplementation Reduces Blood Pressure and Myocardial Infarct Size under Chronic Intermittent Hypoxia, a Major Feature of Sleep Apnea Syndrome
by: Bilgehan Ozcan, et al.
Published: (2022-11-01)

Increased plasma ANGPTL7 levels with increased obstructive sleep apnea severity
by: M. Leentjens, et al.
Published: (2022-08-01)

Comparing the characteristics of positional and nonpositional sleep apnea patients among the Jordanian population
by: Khaled Al Oweidat, et al.
Published: (2022-01-01)

Inflammation pathways as therapeutic targets in angiotensin II induced atrial fibrillation
by: Ailin Hou, et al.
Published: (2025-03-01)

Intermittent hypoxia promotes melanoma lung metastasis via oxidative stress and inflammation responses in a mouse model of obstructive sleep apnea
by: Lian Li, et al.
Published: (2018-02-01)

Glucoregulatory consequences and cardiorespiratory parameters in rats exposed to chronic-intermittent hypoxia: Effects of the duration of exposure and losartan
by: Victor B Fenik, et al.
Published: (2012-04-01)

Risk Factors of Nonalcoholic Fatty Liver Disease and Liver Fibrosis in Non-Obese Patients with Obstructive Sleep Apnea
by: Lian N, et al.
Published: (2022-12-01)

The Renin–Angiotensin System (RAS) in COVID-19 Disease: Where We Are 3 Years after the Beginning of the Pandemic
by: Marco Prato, et al.
Published: (2024-03-01)

A comprehensive review of obstructive sleep apnea
by: Anna Abbasil, et al.
Published: (2021-06-01)

Role of Nonclassical Renin-angiotensin system Axis In Renal Fibrosis
by: Linli eLv, et al.
Published: (2015-04-01)

The Level of Adipokine Metrnl and Its Relationship with Inflammation and Insulin Resistance in Patients with Obstructive Sleep Apnea Syndrome
by: HU Jiayu, REN Lijue, JIN Huanhuan, SUN Tingting, JIN Meina, ZHOU Xueli, WEI Cuiying
Published: (2023-10-01)

Angiotensin-converting enzyme 2 identifies immuno-hot tumors suggesting angiotensin-(1–7) as a sensitizer for chemotherapy and immunotherapy in breast cancer
by: Jie Mei, et al.
Published: (2022-10-01)