Multifunctional injectable hydrogel for effective promotion of cartilage regeneration and protection against osteoarthritis: combined chondroinductive, antioxidative and anti-inflammatory strategy
The regeneration of the articular cartilage defects is characterized by the improvement in the quality of the repaired tissue and the reduction in the potential development of perifocal osteoarthritis (OA). Usually, the injection of dexamethasone (Dex) in the OA joints slows down the progression of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Science and Technology of Advanced Materials |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/14686996.2022.2076568 |
| _version_ | 1797986561738932224 |
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| author | Xueping Dong Canfeng Li Mengdi Zhang YiKun Zhao Zhen Zhao Wenqiang Li Xintao Zhang |
| author_facet | Xueping Dong Canfeng Li Mengdi Zhang YiKun Zhao Zhen Zhao Wenqiang Li Xintao Zhang |
| author_sort | Xueping Dong |
| collection | DOAJ |
| description | The regeneration of the articular cartilage defects is characterized by the improvement in the quality of the repaired tissue and the reduction in the potential development of perifocal osteoarthritis (OA). Usually, the injection of dexamethasone (Dex) in the OA joints slows down the progression of inflammation and relieves pain. However, the anti-inflammatory Dex injected in the joint cavity is rapidly cleared, leading to a poor therapeutic effect. Multifunctional hydrogels with simultaneous chondrogenic differentiation, antioxidative, and anti-inflammatory capacities may represent a promising solution. Therefore, in this work, a novel injectable hydrogel based on double cross-linking of Schiff base bonds and coordination of catechol-Fe was developed. The obtained hydrogel (Gel-DA/DOHA/DMON@Dex@Fe) possessed molding performance in situ, excellent mechanical strength, controllable biodegradability, the on-demand release of the drug, and biocompatibility. The hydrogel system stimulated the HIF-1α signaling pathway and suppressed inflammation thanks to the introduction of DMON@Fe, consequently facilitating chondrogenic differentiation. The synergistic anti-inflammatory effect together with the induction of chondrogenesis by Dex-loaded Gel-DA/DOHA/DMON@Fe hydrogel allowed the promotion of cartilage repair, as demonstrated by in vivo experiments. Hence, the proposed multifunctional scaffold provides a promising advancement in articular cartilage tissue engineering and may have great prospects in the prevention of OA. |
| first_indexed | 2024-04-11T07:34:17Z |
| format | Article |
| id | doaj.art-9e7d2745f212419cb9c87d9338d93bd2 |
| institution | Directory Open Access Journal |
| issn | 1468-6996 1878-5514 |
| language | English |
| last_indexed | 2024-04-11T07:34:17Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Science and Technology of Advanced Materials |
| spelling | doaj.art-9e7d2745f212419cb9c87d9338d93bd22022-12-22T04:36:46ZengTaylor & Francis GroupScience and Technology of Advanced Materials1468-69961878-55142022-12-0123136137510.1080/14686996.2022.2076568Multifunctional injectable hydrogel for effective promotion of cartilage regeneration and protection against osteoarthritis: combined chondroinductive, antioxidative and anti-inflammatory strategyXueping Dong0Canfeng Li1Mengdi Zhang2YiKun Zhao3Zhen Zhao4Wenqiang Li5Xintao Zhang6Department of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, PR ChinaDepartment of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, PR ChinaDepartment of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, PR ChinaDepartment of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, PR ChinaDepartment of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, PR ChinaEngineering Technology Research Center for Sports Assistive Devices of Guangdong, Guangzhou Sport University, Guangzhou, PR ChinaDepartment of Sports Medicine and Rehabilitation, Peking University Shenzhen Hospital, Shenzhen, PR ChinaThe regeneration of the articular cartilage defects is characterized by the improvement in the quality of the repaired tissue and the reduction in the potential development of perifocal osteoarthritis (OA). Usually, the injection of dexamethasone (Dex) in the OA joints slows down the progression of inflammation and relieves pain. However, the anti-inflammatory Dex injected in the joint cavity is rapidly cleared, leading to a poor therapeutic effect. Multifunctional hydrogels with simultaneous chondrogenic differentiation, antioxidative, and anti-inflammatory capacities may represent a promising solution. Therefore, in this work, a novel injectable hydrogel based on double cross-linking of Schiff base bonds and coordination of catechol-Fe was developed. The obtained hydrogel (Gel-DA/DOHA/DMON@Dex@Fe) possessed molding performance in situ, excellent mechanical strength, controllable biodegradability, the on-demand release of the drug, and biocompatibility. The hydrogel system stimulated the HIF-1α signaling pathway and suppressed inflammation thanks to the introduction of DMON@Fe, consequently facilitating chondrogenic differentiation. The synergistic anti-inflammatory effect together with the induction of chondrogenesis by Dex-loaded Gel-DA/DOHA/DMON@Fe hydrogel allowed the promotion of cartilage repair, as demonstrated by in vivo experiments. Hence, the proposed multifunctional scaffold provides a promising advancement in articular cartilage tissue engineering and may have great prospects in the prevention of OA.https://www.tandfonline.com/doi/10.1080/14686996.2022.2076568Dual-crosslinking hydrogelchondrogenic differentiationanti-inflammationcartilage regenerationOA |
| spellingShingle | Xueping Dong Canfeng Li Mengdi Zhang YiKun Zhao Zhen Zhao Wenqiang Li Xintao Zhang Multifunctional injectable hydrogel for effective promotion of cartilage regeneration and protection against osteoarthritis: combined chondroinductive, antioxidative and anti-inflammatory strategy Science and Technology of Advanced Materials Dual-crosslinking hydrogel chondrogenic differentiation anti-inflammation cartilage regeneration OA |
| title | Multifunctional injectable hydrogel for effective promotion of cartilage regeneration and protection against osteoarthritis: combined chondroinductive, antioxidative and anti-inflammatory strategy |
| title_full | Multifunctional injectable hydrogel for effective promotion of cartilage regeneration and protection against osteoarthritis: combined chondroinductive, antioxidative and anti-inflammatory strategy |
| title_fullStr | Multifunctional injectable hydrogel for effective promotion of cartilage regeneration and protection against osteoarthritis: combined chondroinductive, antioxidative and anti-inflammatory strategy |
| title_full_unstemmed | Multifunctional injectable hydrogel for effective promotion of cartilage regeneration and protection against osteoarthritis: combined chondroinductive, antioxidative and anti-inflammatory strategy |
| title_short | Multifunctional injectable hydrogel for effective promotion of cartilage regeneration and protection against osteoarthritis: combined chondroinductive, antioxidative and anti-inflammatory strategy |
| title_sort | multifunctional injectable hydrogel for effective promotion of cartilage regeneration and protection against osteoarthritis combined chondroinductive antioxidative and anti inflammatory strategy |
| topic | Dual-crosslinking hydrogel chondrogenic differentiation anti-inflammation cartilage regeneration OA |
| url | https://www.tandfonline.com/doi/10.1080/14686996.2022.2076568 |
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