A study of adverse maternal-foetal outcomes in nephrotic syndrome combined with preeclampsia
Abstract Background Although the majority of pregnancies with preeclampsia are characterised by elevated blood pressure, preeclampsia is often associated with nephrotic syndrome with similar symptoms such as high proteinuria and bilateral lower limb oedema. In this study, we compared the maternal–fo...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2023-11-01
|
| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-023-06073-8 |
| _version_ | 1827381887827443712 |
|---|---|
| author | Dong Li Minyi Zhang Shuxiu Xu Ziwei Bian Xiaoli Huang Guifang Hu Jing Li |
| author_facet | Dong Li Minyi Zhang Shuxiu Xu Ziwei Bian Xiaoli Huang Guifang Hu Jing Li |
| author_sort | Dong Li |
| collection | DOAJ |
| description | Abstract Background Although the majority of pregnancies with preeclampsia are characterised by elevated blood pressure, preeclampsia is often associated with nephrotic syndrome with similar symptoms such as high proteinuria and bilateral lower limb oedema. In this study, we compared the maternal–foetal outcomes of pregnant women with preeclampsia in a population with nephrotic syndrome and explored the factors that contribute to the corresponding outcomes and disease development. Methods A total of 90 pregnant women were included in this study, of whom 30 had nephrotic syndrome and were diagnosed with preeclampsia during pregnancy, and 60 had nephrotic syndrome alone. Descriptive statistical analyses of baseline data were performed to analyse the effect of combined preeclampsia on maternal and foetal pregnancy outcomes using unadjusted and adjusted logistic regression models. Results In this study, the baseline data of the two study populations demonstrated no differences except for the history of caesarean section and 24-h proteinuria results, which were significantly different (P < 0.05). The risk of preterm birth in the nephrotic syndrome with preeclampsia group was 8.25 (95% CI:3.041–22.084 P < 0.05); for a low birth weight, the risk was 6.00 (95% CI:2.302–15.638 P < 0.05); for foetal distress,the risk was 5.667 (95% CI:2.070–15.514 P < 0.05); and the risk of foetal birth restriction was 7.429 (95% CI: 2.642–20.885 P < 0.05). A risk-based analysis of adverse maternal outcomes yielded a risk of miscarriage of 2.200 (95% CI: 0.584–8.291; P > 0.05). After adjusting the model for each outcome, significant risks of preterm labour, foetal birth restriction, and low birth weight were revealed (P < 0.05). Conclusion Combined preeclampsia has a significantly higher risk of adverse pregnancy outcomes for the foetus.Therefore, the prevention and control of eclampsia in pregnant women should be improved to ensure maternal and neonatal health. |
| first_indexed | 2024-03-08T14:11:23Z |
| format | Article |
| id | doaj.art-9e7ea5376a9d4f169fc8ecbe364b9ce9 |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-03-08T14:11:23Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-9e7ea5376a9d4f169fc8ecbe364b9ce92024-01-14T12:41:55ZengBMCBMC Pregnancy and Childbirth1471-23932023-11-012311710.1186/s12884-023-06073-8A study of adverse maternal-foetal outcomes in nephrotic syndrome combined with preeclampsiaDong Li0Minyi Zhang1Shuxiu Xu2Ziwei Bian3Xiaoli Huang4Guifang Hu5Jing Li6Department of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Obstetrics and Gynecology, Nanfang HospitalDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Obstetrics and Gynecology, Nanfang HospitalAbstract Background Although the majority of pregnancies with preeclampsia are characterised by elevated blood pressure, preeclampsia is often associated with nephrotic syndrome with similar symptoms such as high proteinuria and bilateral lower limb oedema. In this study, we compared the maternal–foetal outcomes of pregnant women with preeclampsia in a population with nephrotic syndrome and explored the factors that contribute to the corresponding outcomes and disease development. Methods A total of 90 pregnant women were included in this study, of whom 30 had nephrotic syndrome and were diagnosed with preeclampsia during pregnancy, and 60 had nephrotic syndrome alone. Descriptive statistical analyses of baseline data were performed to analyse the effect of combined preeclampsia on maternal and foetal pregnancy outcomes using unadjusted and adjusted logistic regression models. Results In this study, the baseline data of the two study populations demonstrated no differences except for the history of caesarean section and 24-h proteinuria results, which were significantly different (P < 0.05). The risk of preterm birth in the nephrotic syndrome with preeclampsia group was 8.25 (95% CI:3.041–22.084 P < 0.05); for a low birth weight, the risk was 6.00 (95% CI:2.302–15.638 P < 0.05); for foetal distress,the risk was 5.667 (95% CI:2.070–15.514 P < 0.05); and the risk of foetal birth restriction was 7.429 (95% CI: 2.642–20.885 P < 0.05). A risk-based analysis of adverse maternal outcomes yielded a risk of miscarriage of 2.200 (95% CI: 0.584–8.291; P > 0.05). After adjusting the model for each outcome, significant risks of preterm labour, foetal birth restriction, and low birth weight were revealed (P < 0.05). Conclusion Combined preeclampsia has a significantly higher risk of adverse pregnancy outcomes for the foetus.Therefore, the prevention and control of eclampsia in pregnant women should be improved to ensure maternal and neonatal health.https://doi.org/10.1186/s12884-023-06073-8Nephrotic syndrome with preeclampsiaNephrotic syndromePregnancy outcomesPrevention |
| spellingShingle | Dong Li Minyi Zhang Shuxiu Xu Ziwei Bian Xiaoli Huang Guifang Hu Jing Li A study of adverse maternal-foetal outcomes in nephrotic syndrome combined with preeclampsia BMC Pregnancy and Childbirth Nephrotic syndrome with preeclampsia Nephrotic syndrome Pregnancy outcomes Prevention |
| title | A study of adverse maternal-foetal outcomes in nephrotic syndrome combined with preeclampsia |
| title_full | A study of adverse maternal-foetal outcomes in nephrotic syndrome combined with preeclampsia |
| title_fullStr | A study of adverse maternal-foetal outcomes in nephrotic syndrome combined with preeclampsia |
| title_full_unstemmed | A study of adverse maternal-foetal outcomes in nephrotic syndrome combined with preeclampsia |
| title_short | A study of adverse maternal-foetal outcomes in nephrotic syndrome combined with preeclampsia |
| title_sort | study of adverse maternal foetal outcomes in nephrotic syndrome combined with preeclampsia |
| topic | Nephrotic syndrome with preeclampsia Nephrotic syndrome Pregnancy outcomes Prevention |
| url | https://doi.org/10.1186/s12884-023-06073-8 |
| work_keys_str_mv | AT dongli astudyofadversematernalfoetaloutcomesinnephroticsyndromecombinedwithpreeclampsia AT minyizhang astudyofadversematernalfoetaloutcomesinnephroticsyndromecombinedwithpreeclampsia AT shuxiuxu astudyofadversematernalfoetaloutcomesinnephroticsyndromecombinedwithpreeclampsia AT ziweibian astudyofadversematernalfoetaloutcomesinnephroticsyndromecombinedwithpreeclampsia AT xiaolihuang astudyofadversematernalfoetaloutcomesinnephroticsyndromecombinedwithpreeclampsia AT guifanghu astudyofadversematernalfoetaloutcomesinnephroticsyndromecombinedwithpreeclampsia AT jingli astudyofadversematernalfoetaloutcomesinnephroticsyndromecombinedwithpreeclampsia AT dongli studyofadversematernalfoetaloutcomesinnephroticsyndromecombinedwithpreeclampsia AT minyizhang studyofadversematernalfoetaloutcomesinnephroticsyndromecombinedwithpreeclampsia AT shuxiuxu studyofadversematernalfoetaloutcomesinnephroticsyndromecombinedwithpreeclampsia AT ziweibian studyofadversematernalfoetaloutcomesinnephroticsyndromecombinedwithpreeclampsia AT xiaolihuang studyofadversematernalfoetaloutcomesinnephroticsyndromecombinedwithpreeclampsia AT guifanghu studyofadversematernalfoetaloutcomesinnephroticsyndromecombinedwithpreeclampsia AT jingli studyofadversematernalfoetaloutcomesinnephroticsyndromecombinedwithpreeclampsia |