A Comparison of 2-Methoxyestradiol Value in Women with Severe Preeclampsia Versus Normotensive Pregnancy
Introduction: Preeclampsia is a pregnancy complication characterized by high blood pressure and proteinuria. Endothelial dysfunction is a major theory suggested as its aetiology. It is caused by anti-angiogenic condition characterized by low Vascular Endothelial Growth Factor (VEGF). An estradio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2017-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/9603/21516_CE[Ra1]_F(GH)_PF1(MSGH)_PFA(GH)_PF2(P_RB).pdf |
| Summary: | Introduction: Preeclampsia is a pregnancy complication
characterized by high blood pressure and proteinuria. Endothelial
dysfunction is a major theory suggested as its aetiology. It is
caused by anti-angiogenic condition characterized by low
Vascular Endothelial Growth Factor (VEGF). An estradiol
metabolite, called 2-Methoxy Estradiol (2-ME), is produced
with the help of Catechol-O-Methyltransferase (COMT). This
substance has an important role in VEGF expression. A 2-ME is
suppressed in women with preeclampsia.
Aim: To compare 2-ME in women with severe preeclampsia and
normotensive pregnancy.
Materials and Methods: A total of 80 subjects qualified the
inclusion and exclusion criteria, were divided into two groups
(40 each): the severe preeclampsia and the normotensive
pregnancy. Blood sample was collected and examined with
the ELISA 2-ME kit (Cayman). The data were compared and
calculated using Fisher-Exact test to examine 2-ME differences
between the two groups.
Results: Women age, parity, and gestational age showed a non
significant difference between both groups. Nonetheless, the
BMI before pregnancy and the history of preeclampsia in the
past pregnancy showed significant differences. In this study,
the 2-ME value was lower in the severe preeclampsia group
compared to the normotensive.
Conclusion: This study concludes that 2-ME value in severe
preeclampsia is lower than normotensive pregnancy. A lower
2-ME value may indicate COMT not producing enough 2-ME
which in turn may cause the pre-eclampsia. |
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| ISSN: | 2249-782X 0973-709X |