Peak width of skeletonized mean diffusivity and its association with age‐related cognitive alterations and vascular risk factors
Abstract Introduction Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age‐related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors. Methods We evaluated 801 stroke‐ and dementia‐fr...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-12-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1016/j.dadm.2019.09.003 |
| _version_ | 1828833511307476992 |
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| author | Bonnie Yin Ka Lam Kam Tat Leung Brian Yiu Lei Zhao J. Matthijs Biesbroek Lisa Au Yumi Tang Kai Wang Yuhua Fan Jian‐Hui Fu Qun Xu Haiqing Song Xiaolin Tian Winnie Chiu Wing Chu Jill Abrigo Lin Shi Ho Ko Alexander Lau Marco Duering Adrian Wong Vincent Chung Tong Mok |
| author_facet | Bonnie Yin Ka Lam Kam Tat Leung Brian Yiu Lei Zhao J. Matthijs Biesbroek Lisa Au Yumi Tang Kai Wang Yuhua Fan Jian‐Hui Fu Qun Xu Haiqing Song Xiaolin Tian Winnie Chiu Wing Chu Jill Abrigo Lin Shi Ho Ko Alexander Lau Marco Duering Adrian Wong Vincent Chung Tong Mok |
| author_sort | Bonnie Yin Ka Lam |
| collection | DOAJ |
| description | Abstract Introduction Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age‐related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors. Methods We evaluated 801 stroke‐ and dementia‐free elderlies with baseline and 3‐year follow‐up assessments. Regression analyses were used to assess the association between age‐related cognitive functions and PSMD. Simple mediation models were used to study the mediation effect of PSMD between vascular risk factors and age‐related cognitive outcomes. Results PSMD was negatively associated with processing speed at baseline and negatively associated with processing and memory scores at 3‐year follow‐up. The association between vascular risk factors and age‐related cognition was mediated by PSMD, as well as other diffusion tensor imaging markers. Discussion PSMD is preferred over other diffusion tensor imaging markers as it is sensitive to age‐related cognitive alterations and calculation is fully automated. PSMD is proposed as a research tool to monitor age‐related cognitive alterations. |
| first_indexed | 2024-12-12T17:20:12Z |
| format | Article |
| id | doaj.art-9e80a455590c49f0b8653e48c4b62d9a |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-12-12T17:20:12Z |
| publishDate | 2019-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-9e80a455590c49f0b8653e48c4b62d9a2022-12-22T00:17:40ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292019-12-0111172172910.1016/j.dadm.2019.09.003Peak width of skeletonized mean diffusivity and its association with age‐related cognitive alterations and vascular risk factorsBonnie Yin Ka Lam0Kam Tat Leung1Brian Yiu2Lei Zhao3J. Matthijs Biesbroek4Lisa Au5Yumi Tang6Kai Wang7Yuhua Fan8Jian‐Hui Fu9Qun Xu10Haiqing Song11Xiaolin Tian12Winnie Chiu Wing Chu13Jill Abrigo14Lin Shi15Ho Ko16Alexander Lau17Marco Duering18Adrian Wong19Vincent Chung Tong Mok20Department of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChinaDepartment of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChinaDepartment of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChinaDepartment of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChinaDepartment of NeurologyBrain Center Rudolf Magnus, University Medical Center UtrechtUtrechtNetherlandsDepartment of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChinaDepartment of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChinaDepartment of NeurologyThe First Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChinaDepartment of Neurology and Stroke CenterThe First Affiliated Hospital, Sun Yat‐sen UniversityGuangzhouChinaDepartment of NeurologyHuashan Hospital, Fudan UniversityShanghaiChinaDepartment of NeurologyRenji Hospital, School of Medicine, Shanghai Jiao Tong UniversityShanghaiChinaDepartment of NeurologyXuanwu Hospital of Capital Medical UniversityBeijingChinaDepartment of NeurologyThe Second Affiliated Hospital, Tianjin Medical UniversityTianjinChinaDepartment of Imaging and Interventional RadiologyResearch Center for Medical Image Computing, The Chinese University of Hong KongShatinHong Kong SARChinaDepartment of Imaging and Interventional RadiologyResearch Center for Medical Image Computing, The Chinese University of Hong KongShatinHong Kong SARChinaBrainNow Research InstituteShenzhenGuangdong ProvinceChinaDepartment of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChinaDepartment of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChinaInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU MunichMunichGermanyDepartment of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChinaDepartment of Medicine and TherapeuticsPrince of Wales Hospital, The Chinese University of Hong KongShatinHong Kong SARChinaAbstract Introduction Only two studies investigated the associations between peak width of skeletonized mean diffusivity (PSMD) and age‐related cognitive alterations, whereas none of the studies investigated the association with vascular risk factors. Methods We evaluated 801 stroke‐ and dementia‐free elderlies with baseline and 3‐year follow‐up assessments. Regression analyses were used to assess the association between age‐related cognitive functions and PSMD. Simple mediation models were used to study the mediation effect of PSMD between vascular risk factors and age‐related cognitive outcomes. Results PSMD was negatively associated with processing speed at baseline and negatively associated with processing and memory scores at 3‐year follow‐up. The association between vascular risk factors and age‐related cognition was mediated by PSMD, as well as other diffusion tensor imaging markers. Discussion PSMD is preferred over other diffusion tensor imaging markers as it is sensitive to age‐related cognitive alterations and calculation is fully automated. PSMD is proposed as a research tool to monitor age‐related cognitive alterations.https://doi.org/10.1016/j.dadm.2019.09.003Small vessel diseaseDiffusion tensor imagingPeak width of skeletonized mean diffusivityProcessing speedCommunity subjects |
| spellingShingle | Bonnie Yin Ka Lam Kam Tat Leung Brian Yiu Lei Zhao J. Matthijs Biesbroek Lisa Au Yumi Tang Kai Wang Yuhua Fan Jian‐Hui Fu Qun Xu Haiqing Song Xiaolin Tian Winnie Chiu Wing Chu Jill Abrigo Lin Shi Ho Ko Alexander Lau Marco Duering Adrian Wong Vincent Chung Tong Mok Peak width of skeletonized mean diffusivity and its association with age‐related cognitive alterations and vascular risk factors Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring Small vessel disease Diffusion tensor imaging Peak width of skeletonized mean diffusivity Processing speed Community subjects |
| title | Peak width of skeletonized mean diffusivity and its association with age‐related cognitive alterations and vascular risk factors |
| title_full | Peak width of skeletonized mean diffusivity and its association with age‐related cognitive alterations and vascular risk factors |
| title_fullStr | Peak width of skeletonized mean diffusivity and its association with age‐related cognitive alterations and vascular risk factors |
| title_full_unstemmed | Peak width of skeletonized mean diffusivity and its association with age‐related cognitive alterations and vascular risk factors |
| title_short | Peak width of skeletonized mean diffusivity and its association with age‐related cognitive alterations and vascular risk factors |
| title_sort | peak width of skeletonized mean diffusivity and its association with age related cognitive alterations and vascular risk factors |
| topic | Small vessel disease Diffusion tensor imaging Peak width of skeletonized mean diffusivity Processing speed Community subjects |
| url | https://doi.org/10.1016/j.dadm.2019.09.003 |
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