Current Status of Lymphangiogenesis: Molecular Mechanism, Immune Tolerance, and Application Prospect
The lymphatic system is a channel for fluid transport and cell migration, but it has always been controversial in promoting and suppressing cancer. VEGFC/VEGFR3 signaling has long been recognized as a major molecular driver of lymphangiogenesis. However, many studies have shown that the neural netwo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/4/1169 |
| _version_ | 1797621870250426368 |
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| author | Hongyang Deng Jiaxing Zhang Fahong Wu Fengxian Wei Wei Han Xiaodong Xu Youcheng Zhang |
| author_facet | Hongyang Deng Jiaxing Zhang Fahong Wu Fengxian Wei Wei Han Xiaodong Xu Youcheng Zhang |
| author_sort | Hongyang Deng |
| collection | DOAJ |
| description | The lymphatic system is a channel for fluid transport and cell migration, but it has always been controversial in promoting and suppressing cancer. VEGFC/VEGFR3 signaling has long been recognized as a major molecular driver of lymphangiogenesis. However, many studies have shown that the neural network of lymphatic signaling is complex. Lymphatic vessels have been found to play an essential role in the immune regulation of tumor metastasis and cardiac repair. This review describes the effects of lipid metabolism, extracellular vesicles, and flow shear forces on lymphangiogenesis. Moreover, the pro-tumor immune tolerance function of lymphatic vessels is discussed, and the tasks of meningeal lymphatic vessels and cardiac lymphatic vessels in diseases are further discussed. Finally, the value of conversion therapy targeting the lymphatic system is introduced from the perspective of immunotherapy and pro-lymphatic biomaterials for lymphangiogenesis. |
| first_indexed | 2024-03-11T09:03:14Z |
| format | Article |
| id | doaj.art-9e822f2e22104d0980d5b7e0300c789b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:03:14Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-9e822f2e22104d0980d5b7e0300c789b2023-11-16T19:37:10ZengMDPI AGCancers2072-66942023-02-01154116910.3390/cancers15041169Current Status of Lymphangiogenesis: Molecular Mechanism, Immune Tolerance, and Application ProspectHongyang Deng0Jiaxing Zhang1Fahong Wu2Fengxian Wei3Wei Han4Xiaodong Xu5Youcheng Zhang6Hepatic-Biliary-Pancreatic Institute, Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaKey Laboratory of the Digestive System Tumors of Gansu Province, Lanzhou University Second Hospital, Lanzhou 730030, ChinaHepatic-Biliary-Pancreatic Institute, Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaHepatic-Biliary-Pancreatic Institute, Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaHepatic-Biliary-Pancreatic Institute, Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaHepatic-Biliary-Pancreatic Institute, Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaHepatic-Biliary-Pancreatic Institute, Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730030, ChinaThe lymphatic system is a channel for fluid transport and cell migration, but it has always been controversial in promoting and suppressing cancer. VEGFC/VEGFR3 signaling has long been recognized as a major molecular driver of lymphangiogenesis. However, many studies have shown that the neural network of lymphatic signaling is complex. Lymphatic vessels have been found to play an essential role in the immune regulation of tumor metastasis and cardiac repair. This review describes the effects of lipid metabolism, extracellular vesicles, and flow shear forces on lymphangiogenesis. Moreover, the pro-tumor immune tolerance function of lymphatic vessels is discussed, and the tasks of meningeal lymphatic vessels and cardiac lymphatic vessels in diseases are further discussed. Finally, the value of conversion therapy targeting the lymphatic system is introduced from the perspective of immunotherapy and pro-lymphatic biomaterials for lymphangiogenesis.https://www.mdpi.com/2072-6694/15/4/1169lymphangiogenesisimmune toleranceimmunotherapymeningeal lymphatic vesselstumor metastasismyocardial infarction |
| spellingShingle | Hongyang Deng Jiaxing Zhang Fahong Wu Fengxian Wei Wei Han Xiaodong Xu Youcheng Zhang Current Status of Lymphangiogenesis: Molecular Mechanism, Immune Tolerance, and Application Prospect Cancers lymphangiogenesis immune tolerance immunotherapy meningeal lymphatic vessels tumor metastasis myocardial infarction |
| title | Current Status of Lymphangiogenesis: Molecular Mechanism, Immune Tolerance, and Application Prospect |
| title_full | Current Status of Lymphangiogenesis: Molecular Mechanism, Immune Tolerance, and Application Prospect |
| title_fullStr | Current Status of Lymphangiogenesis: Molecular Mechanism, Immune Tolerance, and Application Prospect |
| title_full_unstemmed | Current Status of Lymphangiogenesis: Molecular Mechanism, Immune Tolerance, and Application Prospect |
| title_short | Current Status of Lymphangiogenesis: Molecular Mechanism, Immune Tolerance, and Application Prospect |
| title_sort | current status of lymphangiogenesis molecular mechanism immune tolerance and application prospect |
| topic | lymphangiogenesis immune tolerance immunotherapy meningeal lymphatic vessels tumor metastasis myocardial infarction |
| url | https://www.mdpi.com/2072-6694/15/4/1169 |
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