Targeting bone homeostasis regulation: potential of traditional Chinese medicine flavonoids in the treatment of osteoporosis
Osteoporosis is a systemic metabolic disease characterized by disrupted bone formation/resorption and homeostasis. Flavonoids extracted from traditional Chinese medicinal plants regulate bone homeostasis by intervening in differentiating bone marrow mesenchymal stem cells, balancing the bone immune...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1361864/full |
| _version_ | 1797230404327964672 |
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| author | Jiazhe Du Yincang Wang Chengliang Wu Xinyu Zhang Xiaofeng Zhang Xilin Xu |
| author_facet | Jiazhe Du Yincang Wang Chengliang Wu Xinyu Zhang Xiaofeng Zhang Xilin Xu |
| author_sort | Jiazhe Du |
| collection | DOAJ |
| description | Osteoporosis is a systemic metabolic disease characterized by disrupted bone formation/resorption and homeostasis. Flavonoids extracted from traditional Chinese medicinal plants regulate bone homeostasis by intervening in differentiating bone marrow mesenchymal stem cells, balancing the bone immune system, inhibiting oxidative stress response, and reversing iron overload. The target molecules and signaling pathways, such as Wnt/β-catenin and OPG/RANKL/RANK, directly affect osteoblast/osteoclast activity, exhibiting significant potential in the treatment of OP. Therefore, this study presents a systematic review of the recent literature to provide comprehensive information on the traditional Chinese medicine flavonoids involved in the regulation of bone homeostasis. Also, the molecular mechanisms and pharmacological uses of these metabolites are summarized, and their clinical translation and development potential are discussed. |
| first_indexed | 2024-04-24T15:27:57Z |
| format | Article |
| id | doaj.art-9e880cdeb74146d18e9ee07eded13e33 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-24T15:27:57Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-9e880cdeb74146d18e9ee07eded13e332024-04-02T05:24:43ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122024-04-011510.3389/fphar.2024.13618641361864Targeting bone homeostasis regulation: potential of traditional Chinese medicine flavonoids in the treatment of osteoporosisJiazhe Du0Yincang Wang1Chengliang Wu2Xinyu Zhang3Xiaofeng Zhang4Xilin Xu5Graduate School, Heilongjiang University of Traditional Chinese Medicine, Harbin, ChinaGraduate School, Heilongjiang University of Traditional Chinese Medicine, Harbin, ChinaInstitute of Orthopedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaGraduate School, Heilongjiang University of Traditional Chinese Medicine, Harbin, ChinaTeaching and Research Section of Orthopedics and Traumatology, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Orthopedics, The Third Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, ChinaOsteoporosis is a systemic metabolic disease characterized by disrupted bone formation/resorption and homeostasis. Flavonoids extracted from traditional Chinese medicinal plants regulate bone homeostasis by intervening in differentiating bone marrow mesenchymal stem cells, balancing the bone immune system, inhibiting oxidative stress response, and reversing iron overload. The target molecules and signaling pathways, such as Wnt/β-catenin and OPG/RANKL/RANK, directly affect osteoblast/osteoclast activity, exhibiting significant potential in the treatment of OP. Therefore, this study presents a systematic review of the recent literature to provide comprehensive information on the traditional Chinese medicine flavonoids involved in the regulation of bone homeostasis. Also, the molecular mechanisms and pharmacological uses of these metabolites are summarized, and their clinical translation and development potential are discussed.https://www.frontiersin.org/articles/10.3389/fphar.2024.1361864/fullflavonoidsosteoporosistraditional Chinese medicinebone homeostasisflavonols |
| spellingShingle | Jiazhe Du Yincang Wang Chengliang Wu Xinyu Zhang Xiaofeng Zhang Xilin Xu Targeting bone homeostasis regulation: potential of traditional Chinese medicine flavonoids in the treatment of osteoporosis Frontiers in Pharmacology flavonoids osteoporosis traditional Chinese medicine bone homeostasis flavonols |
| title | Targeting bone homeostasis regulation: potential of traditional Chinese medicine flavonoids in the treatment of osteoporosis |
| title_full | Targeting bone homeostasis regulation: potential of traditional Chinese medicine flavonoids in the treatment of osteoporosis |
| title_fullStr | Targeting bone homeostasis regulation: potential of traditional Chinese medicine flavonoids in the treatment of osteoporosis |
| title_full_unstemmed | Targeting bone homeostasis regulation: potential of traditional Chinese medicine flavonoids in the treatment of osteoporosis |
| title_short | Targeting bone homeostasis regulation: potential of traditional Chinese medicine flavonoids in the treatment of osteoporosis |
| title_sort | targeting bone homeostasis regulation potential of traditional chinese medicine flavonoids in the treatment of osteoporosis |
| topic | flavonoids osteoporosis traditional Chinese medicine bone homeostasis flavonols |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1361864/full |
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