The Therapeutic Effect of Acoustic Cavitation on Breast Carcinoma Tumor Model in BALB/c Mice in the Presence of Gold Nanoparticles
Background: Acoustic cavitation, which occurs at high intensities of ultrasound waves, can be fatal for tumor cells. On the other hand, the existence of nanoparticles in a liquid decreases the acoustic cavitation onset threshold. In this study, the combined effects of ultrasound and gold nanoparticl...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2019-09-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/11968 |
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| author | Marziyeh Mirzaeiyan Ahmad Shanei Hossein Hejazi |
| author_facet | Marziyeh Mirzaeiyan Ahmad Shanei Hossein Hejazi |
| author_sort | Marziyeh Mirzaeiyan |
| collection | DOAJ |
| description | Background: Acoustic cavitation, which occurs at high intensities of ultrasound waves, can be fatal for tumor cells. On the other hand, the existence of nanoparticles in a liquid decreases the acoustic cavitation onset threshold. In this study, the combined effects of ultrasound and gold nanoparticles on breast carcinoma tumor model in BALB/c mice were studied.
Methods: The tumor-bearing mice were divided into 4 groups of control, gold nanoparticles, ultrasound, and ultrasound in the presence of gold nanoparticles. Therapeutic effects on tumors were evaluated by measuring relative tumor volume, doubling time, and 5-folding time for tumor volume.
Findings: The 5-folding time showed a significant difference between ultrasound in the presence of the gold nanoparticles and the other groups. The maximum doubling and 5-folding times were found in the ultrasound in the presence of gold nanoparticles group.
Conclusion: Combined effects of ultrasound and gold nanoparticles can be used as a method for increasing the efficiency of the treatment of carcinoma tumors. |
| first_indexed | 2024-03-12T08:51:08Z |
| format | Article |
| id | doaj.art-9e88b34b777b4d698a5ee6ed17dcdc0e |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:51:08Z |
| publishDate | 2019-09-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-9e88b34b777b4d698a5ee6ed17dcdc0e2023-09-02T16:19:12ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2019-09-013753166767210.22122/jims.v37i531.119683441The Therapeutic Effect of Acoustic Cavitation on Breast Carcinoma Tumor Model in BALB/c Mice in the Presence of Gold NanoparticlesMarziyeh Mirzaeiyan0Ahmad Shanei1Hossein Hejazi2PhD Student, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranProfessor, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Acoustic cavitation, which occurs at high intensities of ultrasound waves, can be fatal for tumor cells. On the other hand, the existence of nanoparticles in a liquid decreases the acoustic cavitation onset threshold. In this study, the combined effects of ultrasound and gold nanoparticles on breast carcinoma tumor model in BALB/c mice were studied. Methods: The tumor-bearing mice were divided into 4 groups of control, gold nanoparticles, ultrasound, and ultrasound in the presence of gold nanoparticles. Therapeutic effects on tumors were evaluated by measuring relative tumor volume, doubling time, and 5-folding time for tumor volume. Findings: The 5-folding time showed a significant difference between ultrasound in the presence of the gold nanoparticles and the other groups. The maximum doubling and 5-folding times were found in the ultrasound in the presence of gold nanoparticles group. Conclusion: Combined effects of ultrasound and gold nanoparticles can be used as a method for increasing the efficiency of the treatment of carcinoma tumors.http://jims.mui.ac.ir/index.php/jims/article/view/11968breast tumorsgoldnanoparticleultrasound waves |
| spellingShingle | Marziyeh Mirzaeiyan Ahmad Shanei Hossein Hejazi The Therapeutic Effect of Acoustic Cavitation on Breast Carcinoma Tumor Model in BALB/c Mice in the Presence of Gold Nanoparticles مجله دانشکده پزشکی اصفهان breast tumors gold nanoparticle ultrasound waves |
| title | The Therapeutic Effect of Acoustic Cavitation on Breast Carcinoma Tumor Model in BALB/c Mice in the Presence of Gold Nanoparticles |
| title_full | The Therapeutic Effect of Acoustic Cavitation on Breast Carcinoma Tumor Model in BALB/c Mice in the Presence of Gold Nanoparticles |
| title_fullStr | The Therapeutic Effect of Acoustic Cavitation on Breast Carcinoma Tumor Model in BALB/c Mice in the Presence of Gold Nanoparticles |
| title_full_unstemmed | The Therapeutic Effect of Acoustic Cavitation on Breast Carcinoma Tumor Model in BALB/c Mice in the Presence of Gold Nanoparticles |
| title_short | The Therapeutic Effect of Acoustic Cavitation on Breast Carcinoma Tumor Model in BALB/c Mice in the Presence of Gold Nanoparticles |
| title_sort | therapeutic effect of acoustic cavitation on breast carcinoma tumor model in balb c mice in the presence of gold nanoparticles |
| topic | breast tumors gold nanoparticle ultrasound waves |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/11968 |
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