Microbiota disbiosis is associated with colorectal cancer
The dysbiosis of the human intestinal microbiota is linked to sporadic colorectal carcinoma (CRC). The present study was designed to investigate the gut microbiota distribution features in CRC patients. We performed pyrosequencing based analysis of the 16S rRNA gene V3 region to investigate microbio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-02-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00020/full |
| _version_ | 1828422905468289024 |
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| author | Zhiguang eGao Bomin eGuo Renyuan eGao Qingchao eZhu Huanlong eQin |
| author_facet | Zhiguang eGao Bomin eGuo Renyuan eGao Qingchao eZhu Huanlong eQin |
| author_sort | Zhiguang eGao |
| collection | DOAJ |
| description | The dysbiosis of the human intestinal microbiota is linked to sporadic colorectal carcinoma (CRC). The present study was designed to investigate the gut microbiota distribution features in CRC patients. We performed pyrosequencing based analysis of the 16S rRNA gene V3 region to investigate microbiota of the cancerous tissue and adjacent noncancerous normal tissue in proximal and distal CRC samples. The results revealed that the microbial structures of the CRC patients and healthy individuals differed significantly. Firmicutes and Fusobacteria were over-represented whereas Proteobacteria was under-represented in CRC patients. In addition, Lactococcus and Fusobacterium exhibited a relatively higher abundance while Pseudomonas and Escherichia-Shigella was reduced in cancerous tissues compared to adjacent noncancerous tissues. Meanwhile, the overall microbial structures of proximal and distal colon cancerous tissues were similar; but certain potential pro-oncogenic pathogens were different. These results suggested that the mucosa-associated microbiota is dynamically associated with CRC, which may provide evidences for microbiota-associated diagnostic, prognostic, preventive and therapeutic strategies for CRC. |
| first_indexed | 2024-12-10T15:53:34Z |
| format | Article |
| id | doaj.art-9e8aa8e46689449fb80c521355fb83ae |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-10T15:53:34Z |
| publishDate | 2015-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-9e8aa8e46689449fb80c521355fb83ae2022-12-22T01:42:43ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2015-02-01610.3389/fmicb.2015.00020123865Microbiota disbiosis is associated with colorectal cancerZhiguang eGao0Bomin eGuo1Renyuan eGao2Qingchao eZhu3Huanlong eQin4Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Jiao Tong University Affiliated Sixth People’s HospitalThe dysbiosis of the human intestinal microbiota is linked to sporadic colorectal carcinoma (CRC). The present study was designed to investigate the gut microbiota distribution features in CRC patients. We performed pyrosequencing based analysis of the 16S rRNA gene V3 region to investigate microbiota of the cancerous tissue and adjacent noncancerous normal tissue in proximal and distal CRC samples. The results revealed that the microbial structures of the CRC patients and healthy individuals differed significantly. Firmicutes and Fusobacteria were over-represented whereas Proteobacteria was under-represented in CRC patients. In addition, Lactococcus and Fusobacterium exhibited a relatively higher abundance while Pseudomonas and Escherichia-Shigella was reduced in cancerous tissues compared to adjacent noncancerous tissues. Meanwhile, the overall microbial structures of proximal and distal colon cancerous tissues were similar; but certain potential pro-oncogenic pathogens were different. These results suggested that the mucosa-associated microbiota is dynamically associated with CRC, which may provide evidences for microbiota-associated diagnostic, prognostic, preventive and therapeutic strategies for CRC.http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00020/fullcolorectal cancerProximal colongut dysbiosisDistal colonMucosa-associated microbiota |
| spellingShingle | Zhiguang eGao Bomin eGuo Renyuan eGao Qingchao eZhu Huanlong eQin Microbiota disbiosis is associated with colorectal cancer Frontiers in Microbiology colorectal cancer Proximal colon gut dysbiosis Distal colon Mucosa-associated microbiota |
| title | Microbiota disbiosis is associated with colorectal cancer |
| title_full | Microbiota disbiosis is associated with colorectal cancer |
| title_fullStr | Microbiota disbiosis is associated with colorectal cancer |
| title_full_unstemmed | Microbiota disbiosis is associated with colorectal cancer |
| title_short | Microbiota disbiosis is associated with colorectal cancer |
| title_sort | microbiota disbiosis is associated with colorectal cancer |
| topic | colorectal cancer Proximal colon gut dysbiosis Distal colon Mucosa-associated microbiota |
| url | http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00020/full |
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