Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system.
Obesity is a growing epidemic characterized by excess fat storage in adipocytes. Although lipoprotein receptors play important roles in lipid uptake, their role in controlling food intake and obesity is not known. Here we show that the lipoprotein receptor LRP1 regulates leptin signaling and energy...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC3019112?pdf=render |
| _version_ | 1818433960394358784 |
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| author | Qiang Liu Juan Zhang Celina Zerbinatti Yan Zhan Benedict J Kolber Joachim Herz Louis J Muglia Guojun Bu |
| author_facet | Qiang Liu Juan Zhang Celina Zerbinatti Yan Zhan Benedict J Kolber Joachim Herz Louis J Muglia Guojun Bu |
| author_sort | Qiang Liu |
| collection | DOAJ |
| description | Obesity is a growing epidemic characterized by excess fat storage in adipocytes. Although lipoprotein receptors play important roles in lipid uptake, their role in controlling food intake and obesity is not known. Here we show that the lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis. Conditional deletion of the Lrp1 gene in the brain resulted in an obese phenotype characterized by increased food intake, decreased energy consumption, and decreased leptin signaling. LRP1 directly binds to leptin and the leptin receptor complex and is required for leptin receptor phosphorylation and Stat3 activation. We further showed that deletion of the Lrp1 gene specifically in the hypothalamus by Cre lentivirus injection is sufficient to trigger accelerated weight gain. Together, our results demonstrate that the lipoprotein receptor LRP1, which is critical in lipid metabolism, also regulates food intake and energy homeostasis in the adult central nervous system. |
| first_indexed | 2024-12-14T16:29:24Z |
| format | Article |
| id | doaj.art-9e8c9e1125034e1ea4469513e0b07ae6 |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-12-14T16:29:24Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-9e8c9e1125034e1ea4469513e0b07ae62022-12-21T22:54:37ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852011-01-0191e100057510.1371/journal.pbio.1000575Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system.Qiang LiuJuan ZhangCelina ZerbinattiYan ZhanBenedict J KolberJoachim HerzLouis J MugliaGuojun BuObesity is a growing epidemic characterized by excess fat storage in adipocytes. Although lipoprotein receptors play important roles in lipid uptake, their role in controlling food intake and obesity is not known. Here we show that the lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis. Conditional deletion of the Lrp1 gene in the brain resulted in an obese phenotype characterized by increased food intake, decreased energy consumption, and decreased leptin signaling. LRP1 directly binds to leptin and the leptin receptor complex and is required for leptin receptor phosphorylation and Stat3 activation. We further showed that deletion of the Lrp1 gene specifically in the hypothalamus by Cre lentivirus injection is sufficient to trigger accelerated weight gain. Together, our results demonstrate that the lipoprotein receptor LRP1, which is critical in lipid metabolism, also regulates food intake and energy homeostasis in the adult central nervous system.http://europepmc.org/articles/PMC3019112?pdf=render |
| spellingShingle | Qiang Liu Juan Zhang Celina Zerbinatti Yan Zhan Benedict J Kolber Joachim Herz Louis J Muglia Guojun Bu Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. PLoS Biology |
| title | Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. |
| title_full | Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. |
| title_fullStr | Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. |
| title_full_unstemmed | Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. |
| title_short | Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system. |
| title_sort | lipoprotein receptor lrp1 regulates leptin signaling and energy homeostasis in the adult central nervous system |
| url | http://europepmc.org/articles/PMC3019112?pdf=render |
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