Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells
Th17 cells can transdifferentiate into regulatory T (Treg) cells. Here the authors characterize tumour-driven Th17-to-Tregcell transdifferentiation and identify potential cancer therapy targets.
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms14649 |
| _version_ | 1818857918809767936 |
|---|---|
| author | Stephanie Downs-Canner Sara Berkey Greg M. Delgoffe Robert P. Edwards Tyler Curiel Kunle Odunsi David L. Bartlett Nataša Obermajer |
| author_facet | Stephanie Downs-Canner Sara Berkey Greg M. Delgoffe Robert P. Edwards Tyler Curiel Kunle Odunsi David L. Bartlett Nataša Obermajer |
| author_sort | Stephanie Downs-Canner |
| collection | DOAJ |
| description | Th17 cells can transdifferentiate into regulatory T (Treg) cells. Here the authors characterize tumour-driven Th17-to-Tregcell transdifferentiation and identify potential cancer therapy targets. |
| first_indexed | 2024-12-19T08:48:02Z |
| format | Article |
| id | doaj.art-9e8d4eb2095e4915964c459f3f8ece80 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:48:02Z |
| publishDate | 2017-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9e8d4eb2095e4915964c459f3f8ece802022-12-21T20:28:48ZengNature PortfolioNature Communications2041-17232017-03-018111510.1038/ncomms14649Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cellsStephanie Downs-Canner0Sara Berkey1Greg M. Delgoffe2Robert P. Edwards3Tyler Curiel4Kunle Odunsi5David L. Bartlett6Nataša Obermajer7Department of Surgical Oncology, University of PittsburghDepartment of Surgical Oncology, University of PittsburghUniversity of Pittsburgh Cancer InstituteUniversity of Pittsburgh Cancer InstituteUT Health Science Center at San AntonioDepartments of Gynecologic Oncology and Immunology, Roswell Park Cancer InstituteDepartment of Surgical Oncology, University of PittsburghDepartment of Surgical Oncology, University of PittsburghTh17 cells can transdifferentiate into regulatory T (Treg) cells. Here the authors characterize tumour-driven Th17-to-Tregcell transdifferentiation and identify potential cancer therapy targets.https://doi.org/10.1038/ncomms14649 |
| spellingShingle | Stephanie Downs-Canner Sara Berkey Greg M. Delgoffe Robert P. Edwards Tyler Curiel Kunle Odunsi David L. Bartlett Nataša Obermajer Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells Nature Communications |
| title | Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells |
| title_full | Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells |
| title_fullStr | Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells |
| title_full_unstemmed | Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells |
| title_short | Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells |
| title_sort | suppressive il 17a foxp3 and ex th17 il 17anegfoxp3 treg cells are a source of tumour associated treg cells |
| url | https://doi.org/10.1038/ncomms14649 |
| work_keys_str_mv | AT stephaniedownscanner suppressiveil17afoxp3andexth17il17anegfoxp3tregcellsareasourceoftumourassociatedtregcells AT saraberkey suppressiveil17afoxp3andexth17il17anegfoxp3tregcellsareasourceoftumourassociatedtregcells AT gregmdelgoffe suppressiveil17afoxp3andexth17il17anegfoxp3tregcellsareasourceoftumourassociatedtregcells AT robertpedwards suppressiveil17afoxp3andexth17il17anegfoxp3tregcellsareasourceoftumourassociatedtregcells AT tylercuriel suppressiveil17afoxp3andexth17il17anegfoxp3tregcellsareasourceoftumourassociatedtregcells AT kunleodunsi suppressiveil17afoxp3andexth17il17anegfoxp3tregcellsareasourceoftumourassociatedtregcells AT davidlbartlett suppressiveil17afoxp3andexth17il17anegfoxp3tregcellsareasourceoftumourassociatedtregcells AT natasaobermajer suppressiveil17afoxp3andexth17il17anegfoxp3tregcellsareasourceoftumourassociatedtregcells |