Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells

Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells

Th17 cells can transdifferentiate into regulatory T (Treg) cells. Here the authors characterize tumour-driven Th17-to-Tregcell transdifferentiation and identify potential cancer therapy targets.

Bibliographic Details
Main Authors: Stephanie Downs-Canner, Sara Berkey, Greg M. Delgoffe, Robert P. Edwards, Tyler Curiel, Kunle Odunsi, David L. Bartlett, Nataša Obermajer
Format: Article
Language:English
Published: Nature Portfolio 2017-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14649

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