Fimbria-Fornix Volume Is Associated With Spatial Memory and Olfactory Identification in Humans
White matter pathways that surround the hippocampus comprise its afferent and efferent connections, and are therefore crucial in mediating the function of the hippocampus. We recently demonstrated a role for the hippocampus in both spatial memory and olfactory identification in humans. In the curren...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-01-01
|
| Series: | Frontiers in Systems Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fnsys.2019.00087/full |
| _version_ | 1818148392454324224 |
|---|---|
| author | Louisa Dahmani Blandine Courcot Jamie Near Raihaan Patel Robert S. C. Amaral M. Mallar Chakravarty Véronique D. Bohbot |
| author_facet | Louisa Dahmani Blandine Courcot Jamie Near Raihaan Patel Robert S. C. Amaral M. Mallar Chakravarty Véronique D. Bohbot |
| author_sort | Louisa Dahmani |
| collection | DOAJ |
| description | White matter pathways that surround the hippocampus comprise its afferent and efferent connections, and are therefore crucial in mediating the function of the hippocampus. We recently demonstrated a role for the hippocampus in both spatial memory and olfactory identification in humans. In the current study, we focused our attention on the fimbria-fornix white matter bundle and investigated its relationship with spatial memory and olfactory identification. We administered a virtual navigation task and an olfactory identification task to 55 young healthy adults and measured the volume of the fimbria-fornix. We found that the volume of the right fimbria-fornix and its subdivisions is correlated with both navigational learning and olfactory identification in those who use hippocampus-based spatial memory strategies, and not in those who use caudate nucleus-based navigation strategies. These results are consistent with our recent finding that spatial memory and olfaction rely on similar neural networks and structures. |
| first_indexed | 2024-12-11T12:50:25Z |
| format | Article |
| id | doaj.art-9e8e6224ce764571983504f8f71d2bb1 |
| institution | Directory Open Access Journal |
| issn | 1662-5137 |
| language | English |
| last_indexed | 2024-12-11T12:50:25Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Systems Neuroscience |
| spelling | doaj.art-9e8e6224ce764571983504f8f71d2bb12022-12-22T01:06:42ZengFrontiers Media S.A.Frontiers in Systems Neuroscience1662-51372020-01-011310.3389/fnsys.2019.00087505698Fimbria-Fornix Volume Is Associated With Spatial Memory and Olfactory Identification in HumansLouisa Dahmani0Blandine Courcot1Jamie Near2Raihaan Patel3Robert S. C. Amaral4M. Mallar Chakravarty5Véronique D. Bohbot6Integrated Program in Neuroscience, McGill University, Montreal, QC, CanadaDouglas Brain Imaging Center, Department of Psychiatry, McGill University, Montreal, QC, CanadaDouglas Brain Imaging Center, Department of Psychiatry, McGill University, Montreal, QC, CanadaDouglas Brain Imaging Center, Department of Psychiatry, McGill University, Montreal, QC, CanadaDouglas Brain Imaging Center, Department of Psychiatry, McGill University, Montreal, QC, CanadaDouglas Brain Imaging Center, Department of Psychiatry, McGill University, Montreal, QC, CanadaDouglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, CanadaWhite matter pathways that surround the hippocampus comprise its afferent and efferent connections, and are therefore crucial in mediating the function of the hippocampus. We recently demonstrated a role for the hippocampus in both spatial memory and olfactory identification in humans. In the current study, we focused our attention on the fimbria-fornix white matter bundle and investigated its relationship with spatial memory and olfactory identification. We administered a virtual navigation task and an olfactory identification task to 55 young healthy adults and measured the volume of the fimbria-fornix. We found that the volume of the right fimbria-fornix and its subdivisions is correlated with both navigational learning and olfactory identification in those who use hippocampus-based spatial memory strategies, and not in those who use caudate nucleus-based navigation strategies. These results are consistent with our recent finding that spatial memory and olfaction rely on similar neural networks and structures.https://www.frontiersin.org/article/10.3389/fnsys.2019.00087/fullspatial memorynavigationhippocampusfimbria-fornixwhite matterolfaction |
| spellingShingle | Louisa Dahmani Blandine Courcot Jamie Near Raihaan Patel Robert S. C. Amaral M. Mallar Chakravarty Véronique D. Bohbot Fimbria-Fornix Volume Is Associated With Spatial Memory and Olfactory Identification in Humans Frontiers in Systems Neuroscience spatial memory navigation hippocampus fimbria-fornix white matter olfaction |
| title | Fimbria-Fornix Volume Is Associated With Spatial Memory and Olfactory Identification in Humans |
| title_full | Fimbria-Fornix Volume Is Associated With Spatial Memory and Olfactory Identification in Humans |
| title_fullStr | Fimbria-Fornix Volume Is Associated With Spatial Memory and Olfactory Identification in Humans |
| title_full_unstemmed | Fimbria-Fornix Volume Is Associated With Spatial Memory and Olfactory Identification in Humans |
| title_short | Fimbria-Fornix Volume Is Associated With Spatial Memory and Olfactory Identification in Humans |
| title_sort | fimbria fornix volume is associated with spatial memory and olfactory identification in humans |
| topic | spatial memory navigation hippocampus fimbria-fornix white matter olfaction |
| url | https://www.frontiersin.org/article/10.3389/fnsys.2019.00087/full |
| work_keys_str_mv | AT louisadahmani fimbriafornixvolumeisassociatedwithspatialmemoryandolfactoryidentificationinhumans AT blandinecourcot fimbriafornixvolumeisassociatedwithspatialmemoryandolfactoryidentificationinhumans AT jamienear fimbriafornixvolumeisassociatedwithspatialmemoryandolfactoryidentificationinhumans AT raihaanpatel fimbriafornixvolumeisassociatedwithspatialmemoryandolfactoryidentificationinhumans AT robertscamaral fimbriafornixvolumeisassociatedwithspatialmemoryandolfactoryidentificationinhumans AT mmallarchakravarty fimbriafornixvolumeisassociatedwithspatialmemoryandolfactoryidentificationinhumans AT veroniquedbohbot fimbriafornixvolumeisassociatedwithspatialmemoryandolfactoryidentificationinhumans |