Influence of the carbohydrate fragment position in the macrocycle of chlorine e6 trimethyl ester glycosylated derivatives on their in vitro photo- induced activity
<p>The physicochemical and photophysical properties, as well as photo-induced activity, of glycoconjugates based on chlorine е<sub>6</sub> trimethyl ether with various positions of carbohydrate fragment in the macrocycle have been studied. The photo-induced activity was investigate...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2014-01-01
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| Series: | Biomedical Photonics |
| Subjects: | |
| Online Access: | http://www.pdt-journal.com:80/jour/article/view/30 |
| Summary: | <p>The physicochemical and photophysical properties, as well as photo-induced activity, of glycoconjugates based on chlorine е<sub>6</sub> trimethyl ether with various positions of carbohydrate fragment in the macrocycle have been studied. The photo-induced activity was investigated in the human (HEp2, A549 and HT29) and animal (LLC) cell lines. The tested compounds showed in vitro both high photo-induced activity and high stability in the dark. The photosensitizer with galactose in the A pirrole ring demonstrated the highest activity (the half maximal inhibitory concentration (ИК<sub>50</sub>) varied from 27±2 nM to 75±5 nM in tests on different cell lines). Dyes with sugar substitutes in the C pirrole ring were 5–10 times less active.</p><p> </p> |
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| ISSN: | 2413-9432 |