Growth Abnormalities as a Risk Factor of Adverse Neonatal Outcome in Hypertensive Pregnancies—A Single-Center Retrospective Cohort Study
(1) Background: Hypertensive disorders of pregnancy (HDP) include gestational hypertension (GH), chronic hypertension (CH), preeclampsia (PE), and preeclampsia superimposed on chronic hypertension (CH with PE). HDP is associated with several short and long-term perinatal and neonatal complications,...
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MDPI AG
2021-06-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/6/522 |
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| author | Anna Kajdy Stepan Feduniw Jan Modzelewski Dorota Sys Dagmara Filipecka-Tyczka Katarzyna Muzyka-Placzyńska Paweł Kiczmer Bartłomiej Grabowski Michał Rabijewski |
| author_facet | Anna Kajdy Stepan Feduniw Jan Modzelewski Dorota Sys Dagmara Filipecka-Tyczka Katarzyna Muzyka-Placzyńska Paweł Kiczmer Bartłomiej Grabowski Michał Rabijewski |
| author_sort | Anna Kajdy |
| collection | DOAJ |
| description | (1) Background: Hypertensive disorders of pregnancy (HDP) include gestational hypertension (GH), chronic hypertension (CH), preeclampsia (PE), and preeclampsia superimposed on chronic hypertension (CH with PE). HDP is associated with several short and long-term perinatal and neonatal complications, such as newborn growth restriction and death. This study aimed to establish the association between HDP, newborn growth abnormalities, and neonatal outcome. (2) Methods: This is a single-center retrospective cohort study of 63651 singleton deliveries. (3) Results: Univariate analysis showed a significantly increased risk of intrauterine and neonatal death associated with maternal hypertension and growth disorders. There were differences between growth charts used, with the highest risk of stillbirth for SGA defined by the Intergrowth chart (OR 17.2) and neonatal death for newborn growth restriction (NGR) based on Intergrowth (OR 19.1). Multivariate analysis showed that NGR is a stronger risk factor of neonatal death than SGA only. (4) Conclusions: HDP is significantly associated with growth abnormalities and is an independent risk factor of adverse outcomes. The presence of newborn growth restriction is strongly associated with the risk of neonatal death. The choice of growth chart has a substantial effect on the percentage of diagnosis of SGA and NGR. |
| first_indexed | 2024-03-10T10:15:46Z |
| format | Article |
| id | doaj.art-9e8eef5bd80645169807eb95dd7e40ac |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T10:15:46Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-9e8eef5bd80645169807eb95dd7e40ac2023-11-22T00:49:07ZengMDPI AGChildren2227-90672021-06-018652210.3390/children8060522Growth Abnormalities as a Risk Factor of Adverse Neonatal Outcome in Hypertensive Pregnancies—A Single-Center Retrospective Cohort StudyAnna Kajdy0Stepan Feduniw1Jan Modzelewski2Dorota Sys3Dagmara Filipecka-Tyczka4Katarzyna Muzyka-Placzyńska5Paweł Kiczmer6Bartłomiej Grabowski7Michał Rabijewski8Department of Reproductive Health, Centre of Postgraduate Medical Education, 01-004 Warsaw, PolandDepartment of Reproductive Health, Centre of Postgraduate Medical Education, 01-004 Warsaw, PolandDepartment of Reproductive Health, Centre of Postgraduate Medical Education, 01-004 Warsaw, PolandDepartment of Reproductive Health, Centre of Postgraduate Medical Education, 01-004 Warsaw, PolandDepartment of Reproductive Health, Centre of Postgraduate Medical Education, 01-004 Warsaw, PolandDepartment of Reproductive Health, Centre of Postgraduate Medical Education, 01-004 Warsaw, PolandDepartment and Chair of Pathomorphology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandFaculty of Medicine, Lazarski University, 02-662 Warsaw, PolandDepartment of Reproductive Health, Centre of Postgraduate Medical Education, 01-004 Warsaw, Poland(1) Background: Hypertensive disorders of pregnancy (HDP) include gestational hypertension (GH), chronic hypertension (CH), preeclampsia (PE), and preeclampsia superimposed on chronic hypertension (CH with PE). HDP is associated with several short and long-term perinatal and neonatal complications, such as newborn growth restriction and death. This study aimed to establish the association between HDP, newborn growth abnormalities, and neonatal outcome. (2) Methods: This is a single-center retrospective cohort study of 63651 singleton deliveries. (3) Results: Univariate analysis showed a significantly increased risk of intrauterine and neonatal death associated with maternal hypertension and growth disorders. There were differences between growth charts used, with the highest risk of stillbirth for SGA defined by the Intergrowth chart (OR 17.2) and neonatal death for newborn growth restriction (NGR) based on Intergrowth (OR 19.1). Multivariate analysis showed that NGR is a stronger risk factor of neonatal death than SGA only. (4) Conclusions: HDP is significantly associated with growth abnormalities and is an independent risk factor of adverse outcomes. The presence of newborn growth restriction is strongly associated with the risk of neonatal death. The choice of growth chart has a substantial effect on the percentage of diagnosis of SGA and NGR.https://www.mdpi.com/2227-9067/8/6/522pregnancy hypertensionprepregnancy hypertensionpreeclampsiagrowth chartsmall for gestational agelarge for gestational age |
| spellingShingle | Anna Kajdy Stepan Feduniw Jan Modzelewski Dorota Sys Dagmara Filipecka-Tyczka Katarzyna Muzyka-Placzyńska Paweł Kiczmer Bartłomiej Grabowski Michał Rabijewski Growth Abnormalities as a Risk Factor of Adverse Neonatal Outcome in Hypertensive Pregnancies—A Single-Center Retrospective Cohort Study Children pregnancy hypertension prepregnancy hypertension preeclampsia growth chart small for gestational age large for gestational age |
| title | Growth Abnormalities as a Risk Factor of Adverse Neonatal Outcome in Hypertensive Pregnancies—A Single-Center Retrospective Cohort Study |
| title_full | Growth Abnormalities as a Risk Factor of Adverse Neonatal Outcome in Hypertensive Pregnancies—A Single-Center Retrospective Cohort Study |
| title_fullStr | Growth Abnormalities as a Risk Factor of Adverse Neonatal Outcome in Hypertensive Pregnancies—A Single-Center Retrospective Cohort Study |
| title_full_unstemmed | Growth Abnormalities as a Risk Factor of Adverse Neonatal Outcome in Hypertensive Pregnancies—A Single-Center Retrospective Cohort Study |
| title_short | Growth Abnormalities as a Risk Factor of Adverse Neonatal Outcome in Hypertensive Pregnancies—A Single-Center Retrospective Cohort Study |
| title_sort | growth abnormalities as a risk factor of adverse neonatal outcome in hypertensive pregnancies a single center retrospective cohort study |
| topic | pregnancy hypertension prepregnancy hypertension preeclampsia growth chart small for gestational age large for gestational age |
| url | https://www.mdpi.com/2227-9067/8/6/522 |
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