Astrocyte atrophy and immune dysfunction in self-harming macaques.
Self-injurious behavior (SIB) is a complex condition that exhibits a spectrum of abnormal neuropsychological and locomotor behaviors. Mechanisms for neuropathogenesis could include irregular immune activation, host soluble factors, and astrocyte dysfunction.We examined the role of astrocytes as modu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3724606?pdf=render |
| _version_ | 1818050070002532352 |
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| author | Kim M Lee Kevin B Chiu Hope A Sansing Fiona M Inglis Kate C Baker Andrew G MacLean |
| author_facet | Kim M Lee Kevin B Chiu Hope A Sansing Fiona M Inglis Kate C Baker Andrew G MacLean |
| author_sort | Kim M Lee |
| collection | DOAJ |
| description | Self-injurious behavior (SIB) is a complex condition that exhibits a spectrum of abnormal neuropsychological and locomotor behaviors. Mechanisms for neuropathogenesis could include irregular immune activation, host soluble factors, and astrocyte dysfunction.We examined the role of astrocytes as modulators of immune function in macaques with SIB. We measured changes in astrocyte morphology and function. Paraffin sections of frontal cortices from rhesus macaques identified with SIB were stained for glial fibrillary acidic protein (GFAP) and Toll-like receptor 2 (TLR2). Morphologic features of astrocytes were determined using computer-assisted camera lucida.There was atrophy of white matter astrocyte cell bodies, decreased arbor length in both white and gray matter astrocytes, and decreased bifurcations and tips on astrocytes in animals with SIB. This was combined with a five-fold increase in the proportion of astrocytes immunopositive for TLR2.These results provide direct evidence that SIB induces immune activation of astrocytes concomitant with quantifiably different morphology. |
| first_indexed | 2024-12-10T10:47:37Z |
| format | Article |
| id | doaj.art-9e8f580a6582463d8997ab671aba70c6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T10:47:37Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9e8f580a6582463d8997ab671aba70c62022-12-22T01:52:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e6998010.1371/journal.pone.0069980Astrocyte atrophy and immune dysfunction in self-harming macaques.Kim M LeeKevin B ChiuHope A SansingFiona M InglisKate C BakerAndrew G MacLeanSelf-injurious behavior (SIB) is a complex condition that exhibits a spectrum of abnormal neuropsychological and locomotor behaviors. Mechanisms for neuropathogenesis could include irregular immune activation, host soluble factors, and astrocyte dysfunction.We examined the role of astrocytes as modulators of immune function in macaques with SIB. We measured changes in astrocyte morphology and function. Paraffin sections of frontal cortices from rhesus macaques identified with SIB were stained for glial fibrillary acidic protein (GFAP) and Toll-like receptor 2 (TLR2). Morphologic features of astrocytes were determined using computer-assisted camera lucida.There was atrophy of white matter astrocyte cell bodies, decreased arbor length in both white and gray matter astrocytes, and decreased bifurcations and tips on astrocytes in animals with SIB. This was combined with a five-fold increase in the proportion of astrocytes immunopositive for TLR2.These results provide direct evidence that SIB induces immune activation of astrocytes concomitant with quantifiably different morphology.http://europepmc.org/articles/PMC3724606?pdf=render |
| spellingShingle | Kim M Lee Kevin B Chiu Hope A Sansing Fiona M Inglis Kate C Baker Andrew G MacLean Astrocyte atrophy and immune dysfunction in self-harming macaques. PLoS ONE |
| title | Astrocyte atrophy and immune dysfunction in self-harming macaques. |
| title_full | Astrocyte atrophy and immune dysfunction in self-harming macaques. |
| title_fullStr | Astrocyte atrophy and immune dysfunction in self-harming macaques. |
| title_full_unstemmed | Astrocyte atrophy and immune dysfunction in self-harming macaques. |
| title_short | Astrocyte atrophy and immune dysfunction in self-harming macaques. |
| title_sort | astrocyte atrophy and immune dysfunction in self harming macaques |
| url | http://europepmc.org/articles/PMC3724606?pdf=render |
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